Serum iron is a medical laboratory test that measures the amount of circulating iron that is bound to transferrin and freely circulate in the blood. Clinicians order this laboratory test when they are concerned about iron deficiency, which can cause anemia and other problems. 65% of the iron in the body is bound up in hemoglobin molecules in red blood cells. About 4% is bound up in myoglobin molecules. Around 30% of the iron in the body is stored as ferritin or hemosiderin in the spleen, the bone marrow and the liver. Small amounts of iron can be found in other molecules in cells throughout the body. None of this iron is directly accessible by testing the serum.[citation needed]}
However, some iron is circulating in the serum. Transferrin is a molecule produced by the liver that binds one or two iron(III) ions, i.e. ferric iron, Fe3+; transferrin is essential if stored iron is to be moved and used. Most of the time, about 30% of the available sites on the transferrin molecule are filled. The test for serum iron uses blood drawn from veins to measure the iron ions that are bound to transferrin and circulating in the blood. This test should be done after 12 hours of fasting. The extent to which sites on transferrin molecules are filled by iron ions can be another helpful clinical indicator, known as percent transferrin saturation. Another lab test saturates the sample to measure the total amount of transferrin; this test is called total iron-binding capacity (TIBC). These three tests are generally done at the same time, and taken together are an important part of the diagnostic process for conditions such as anemia, iron deficiency anemia, anemia of chronic disease and haemochromatosis.[citation needed]
Serumiron is a medical laboratory test that measures the amount of circulating iron that is bound to transferrin and freely circulate in the blood. Clinicians...
is the value of serumiron divided by the total iron-binding capacity of the available transferrin, the main protein that binds iron in the blood, this...
iron overload. Ferritin is found in most tissues as a cytosolic protein, but small amounts are secreted into the serum where it functions as an iron carrier...
complete blood count hemoglobin serumiron total iron binding capacity serum ferritin bone marrow examination (rarely) Note: Iron therapy must be suspended...
of elemental iron per dose. The diagnosis of iron poisoning is based on clinical presentation including laboratory tests for serumiron concentrations...
2012-11-02 at the Wayback Machine Bloodbook.Com Slon S (2006-09-22). "SerumIron". University of Illinois Medical Center. Archived from the original on...
the same tests are iron panel, iron profile, iron indices, iron status or iron studies. Serumiron Ferritin Transferrin Total iron-binding capacity (TIBC)...
present – even when iron deficiency progresses to iron-deficiency anemia. Low serum ferritin (see below) Low serumiron High TIBC (total iron binding capacity)...
chromosome band 3q21. Medical professionals may check serum transferrin level in iron deficiency and in iron overload disorders such as hemochromatosis. Drosophila...
entry of iron into the circulation in mammals. During conditions in which the hepcidin level is abnormally high, such as inflammation, serumiron falls due...
Iron supplements, also known as iron salts and iron pills, are a number of iron formulations used to treat and prevent iron deficiency including iron...
diagnosing and monitoring iron overload. Blood tests are usually the initial test if there is a clinical suspicion of iron overload. Serum ferritin testing is...
cancer patients. Similarly, genetic variations in iron transporter genes known to increase serumiron levels also reduce lifespan and the average number...
when their iron levels were treated, suggesting the association between serumiron levels and symptoms of pagophagia. In another case, an individual who...
These lab findings include: leukocytosis, elevated creatine kinase, low serumiron. The signs and symptoms of malignant catatonia overlap significantly with...
to acute iron deficiency due to the slow transport of iron through the blood brain barrier. Acute fluctuations in iron status (marked by serum ferritin...
other tests, such as: ESR, serumiron, transferrin, RBC folate level, hemoglobin electrophoresis, renal function tests (e.g. serum creatinine) although the...
selection of important effects. ↓: reduced serum concentration or structure parameter; ↑: increased serum concentration or structure parameter; ↔: no...
Human serum albumin is the serum albumin found in human blood. It is the most abundant protein in human blood plasma; it constitutes about half of serum protein...
divalent iron, this strategy has been maintained throughout evolution as it plays crucial physiological functions. The serumiron pool maintains iron in soluble...
suggested to be screened for iron overload using serum ferritin as a marker. If serum ferritin exceeds 1000 ng/mL, iron overload is very likely the cause...
erythrocytes are ringed sideroblasts. Serumiron, percentage saturation and ferritin are increased. The total iron-binding capacity of the cells is normal...
normal mobilization of iron from its storage sites. Thus, in a copper- deficient state; iron cannot be released à low serumiron and hemoglobin levels...
iron refractory iron-deficiency anemia (IRIDA). Patients with IRIDA have very low serumiron and transferrin saturation, but their serum ferritin is normal...
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