Chemical structures for Watson–Crick and Hoogsteen A•T and G•C+ base pairs. The Hoogsteen geometry can be achieved by purine rotation around the glycosidic bond (χ) and base-flipping (θ), affecting simultaneously C8 and C1′ (yellow).[1]
A Hoogsteen base pair is a variation of base-pairing in nucleic acids such as the A•T pair. In this manner, two nucleobases, one on each strand, can be held together by hydrogen bonds in the major groove. A Hoogsteen base pair applies the N7 position of the purine base (as a hydrogen bond acceptor) and C6 amino group (as a donor), which bind the Watson–Crick (N3–C4) face of the pyrimidine base.
^Evgenia N. Nikolova; Eunae Kim; Abigail A. Wise; Patrick J. O'Brien; Ioan Andricioaei; Hashim M. Al-Hashimi (2011). "Transient Hoogsteen base pairs in canonical duplex DNA". Nature. 470 (7335): 498–502. Bibcode:2011Natur.470..498N. doi:10.1038/nature09775. PMC 3074620. PMID 21270796.
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A Hoogsteenbasepair is a variation of base-pairing in nucleic acids such as the A•T pair. In this manner, two nucleobases, one on each strand, can be...
Information on Aminoacyl tRNA Synthetases and Genomic tRNA Database. BasepairHoogsteenbasepair Synonymous substitution These relationships can be further observed...
is called a Watson-Crick basepair. DNA with high GC-content is more stable than DNA with low GC-content. A Hoogsteenbasepair (hydrogen bonding the 6-carbon...
These modifications can affect the ability of the base to hydrogen-bond, resulting in incorrect base-pairing, and, as a consequence, mutations in the DNA....
structures. These structures consist of several combinations of basepair and Hoogsteen interactions. For example, the GGC triplex (GGC amino(N-2)-N-7...
wobble basepair and Hoogsteenbasepair, also occur—particularly in RNA—giving rise to complex and functional tertiary structures. Importantly, pairing is...
duplex; the duplex consists of Watson-Crick basepairing while the third strand binds via Hoogsteenbasepairing. The collagen triple helix has several characteristics...
5-methylcytosine to thymine, producing G:U and G:T basepairs. If the improper uracils or thymines in these basepairs are not removed before DNA replication, they...
appear frequently in the telomeric regions of DNA. G-quadruplex Hoogsteenbasepair Heterochromatin Regulation of gene expression Guanine Telomere Kogut...
alternative of Watson-Crick basepairing, called the Hoogsteenbasepairing that can form triple DNA strand, was discovered by Karst Hoogsteen in 1963. Aaron Klug...
carry out its task as a translesion polymerase. Pol ι only uses Hoogsteenbasepairing, during DNA synthesis, it will add adenine opposite to thymine in...
Watson and Crick basepairs are indicated by a "•" or a "-" or a "." (example: A•T, or poly(rC)•2poly(rC)). Hoogsteen triple helix basepairs are indicated...
quadruple-stranded and other more complex DNA molecular structures required Hoogsteenbasepairing. The entire field of synthetic biology began with work by researchers...
photodimer using Watson-Crick basepairing and the second adenine will be added in its syn conformation using Hoogsteenbasepairing. From a cellular perspective...
are known to form. A CGG repeat will form a G-quadruplex due to Hoogsteenbasepairing, while a GAA repeat forms a triplex due to negative supercoiling...
Oligodeoxynucleotide, an ODN with immunostimulatory properties Polypurine reverse-Hoogsteen hairpins, PPRHs, oligonucleotides that can bind either DNA or RNA and...
types of base-pairing interactions, including Watson-Crick and Hoogsteenbasepairs. Depending on the complexity of the method, single basepairs may be...
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