RNA base pair that does not follow Watson-Crick base pair rules
Wobble base pairs for inosine and guanine
A wobble base pair is a pairing between two nucleotides in RNA molecules that does not follow Watson-Crick base pair rules.[1] The four main wobble base pairs are guanine-uracil (G-U), hypoxanthine-uracil (I-U), hypoxanthine-adenine (I-A), and hypoxanthine-cytosine (I-C). In order to maintain consistency of nucleic acid nomenclature, "I" is used for hypoxanthine because hypoxanthine is the nucleobase of inosine;[2]
nomenclature otherwise follows the names of nucleobases and their corresponding nucleosides (e.g., "G" for both guanine and guanosine – as well as for deoxyguanosine). The thermodynamic stability of a wobble base pair is comparable to that of a Watson-Crick base pair. Wobble base pairs are fundamental in RNA secondary structure and are critical for the proper translation of the genetic code.
^Campbell, Neil; Reece, Jane B. (2011). Biology (9th ed.). Boston: Benjamin Cummings. pp. 339–342. ISBN 978-0321558237.
^Kuchin, Sergei (19 May 2011). "Covering All the Bases in Genetics: Simple Shorthands and Diagrams for Teaching Base Pairing to Biology Undergraduates". Journal of Microbiology & Biology Education. 12 (1): 64–66. doi:10.1128/jmbe.v12i1.267. PMC 3577215. PMID 23653747. Archived from the original on 17 October 2013. The correct name of the base in inosine (which is a nucleoside) is hypoxanthine, however, for consistency with the nucleic acid nomenclature, the shorthand [I] is more appropriate...
wobblebasepair is a pairing between two nucleotides in RNA molecules that does not follow Watson-Crick basepair rules. The four main wobblebase pairs...
with two hydrogen bonds, does occur fairly often in RNA (see wobblebasepair). Paired DNA and RNA molecules are comparatively stable at room temperature...
transitions are less likely to result in amino acid substitutions (due to wobblebasepair), and are therefore more likely to persist as "silent substitutions"...
of modified bases in the first base of the anticodon of the tRNA, and the base-pair formed is called a wobblebasepair. The modified bases include inosine...
modification Protein dynamics RNA tertiary structure Translation (genetics) Wobblebasepair Ada Yonath—Israeli crystallographer known for her pioneering work on...
tRNAs and is essential for proper translation of the genetic code in wobblebasepairs. Knowledge of inosine metabolism has led to advances in immunotherapy...
complementary basepairs to one or more codons for an amino acid. Some anticodons pair with more than one codon due to wobblebasepairing. Frequently,...
one tRNA can have a non-standard wobblebase in position three of the anti-codon, which recognises more than one base in the codon. In the above phenylalanine...
of their original codon, but UAA suppressors also read UAG due to wobblebasepairing. UGA suppressors are very rare. Another hurdle to pass in this technique...
among other things, different basepairing and base stacking properties. Examples include universal bases, which can pair with all four canonical bases...
trying to be different". He approached Jah Wobble (né John Wardle) about forming a band together. The pair had been friends since the early 1970s when...
orientations, there are many G-U wobblebasepairs and their reverse complements A-C pairs, and both strands have too many A-C pairs to confidently establish...
usually occur on the first base on the anticodon (position 34 or the wobblebase position) which basepairs with the third base on the codon and are critical...
basepairing, therefore rendering that particular dsRNA less able to produce siRNA, which interferes with the RNAi pathway. The wobblebasepairing causes...
Tomatoes reported an approval rating of 89% with an average score of 8.13/10, based on 18 reviews. The website's critics consensus reads, "The third season...
Sam and a soldier boy, late-1950s Jayne Mansfield water bottle, various wobble toys, and a Philco Predicta TV. Next, they truck to Indiana to meet a small...
to adjust the stereo base (parallax) in proportion to the zoom (perspective). If a picture is taken with a stereo camera (or pair of cameras) and a 4X...
brings Amy a racehorse. Cassandra's initial diagnosis is that the horse has Wobbler disease. Janice feels the need to have the horse euthanized due to the...
Jones gave him the name Johnny Rotten, and Ritchie nicknamed Wardle Jah Wobble. The four young men started hanging around the King's Road in Chelsea, London...
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