Hippuric acid information

Hippuric acid
Names
	IUPAC name N-Benzoylglycine
	Preferred IUPAC name Benzamidoacetic acid
	Other names Hippuric acid; Benzoyl glycocoll; Benzoyl amidoacetic acid;
Identifiers
CAS Number	495-69-2 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:18089 ;
ChEMBL	ChEMBL461 ;
ChemSpider	451 ;
ECHA InfoCard	100.007.098
KEGG	C01586 ;
PubChem CID	464;
UNII	TE0865N2ET ;
CompTox Dashboard (EPA)	DTXSID9046073 ;
	InChI InChI=1S/C9H9NO3/c11-8(12)6-10-9(13)7-4-2-1-3-5-7/h1-5H,6H2,(H,10,13)(H,11,12) Key: QIAFMBKCNZACKA-UHFFFAOYSA-N ; InChI=1/C9H9NO3/c11-8(12)6-10-9(13)7-4-2-1-3-5-7/h1-5H,6H2,(H,10,13)(H,11,12) Key: QIAFMBKCNZACKA-UHFFFAOYAD;
	SMILES OC(=O)CNC(=O)c1ccccc1;
Properties
Chemical formula	C9H9NO3
Molar mass	179.175 g·mol−1
Density	1.371 g/cm3
Melting point	187 to 188 °C (369 to 370 °F; 460 to 461 K)
Boiling point	240 °C (464 °F; 513 K) (decomposes)
Hazards
Safety data sheet (SDS)	Material Safety Data Sheet
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Hippuric acid (Gr. hippos, horse, ouron, urine) is a carboxylic acid and organic compound. It is found in urine and is formed from the combination of benzoic acid and glycine. Levels of hippuric acid rise with the consumption of phenolic compounds (such as in fruit juice, tea and wine). The phenols are first converted to benzoic acid, and then to hippuric acid and excreted in urine.^[1]

Hippuric acid crystallizes in rhombic prisms which are readily soluble in hot water, melt at 187 °C, and decompose at about 240 °C.^[2] High concentrations of hippuric acid may also indicate a toluene intoxication; however, scientists have called this correlation into question because there are other variables that affect levels of hippuric acid.^[3] When many aromatic compounds such as benzoic acid and toluene are taken internally, they are converted to hippuric acid by reaction with the amino acid, glycine.

^ Wishart, David S.; Guo, An Chi; Oler, Eponine; Wang, Fel; Anjum, Afia; Peters, Harrison; Dizon, Raynard; Sayeeda, Zinat; Tian, Siyang; Lee, Brian L.; Berjanskii, Mark; Mah, Robert; Yamamoto, Mai; Jovel Castillo, Juan; Torres Calzada, Claudia; Hiebert Giesbrecht, Mickel; Lui, Vicki W.; Varshavi, Dorna; Varshavi, Dorsa; Allen, Dana; Arndt, David; Khetarpal, Nitya; Sivakumaran, Aadhavya; Harford, Karxena; Sanford, Selena; Yee, Kristen; Cao, Xuan; Budinsky, Zachary; Liigand, Jaanus; Zhang, Lun; Zheng, Jiamin; Mandal, Rupasri; Karu, Naama; Dambrova, Maija; Schiöth, Helgi B.; Gautam, Vasuk. "Showing metabocard for Hippuric acid (HMDB0000714)". Human Metabolome Database, HMDB. 5.0.
^ One or more of the preceding sentences incorporates text from a publication now in the public domain: Chisholm, Hugh, ed. (1911). "Hippuric Acid". Encyclopædia Britannica. Vol. 13 (11th ed.). Cambridge University Press. p. 523.
^ Pero, RW (2010). "Health consequences of catabolic synthesis of hippuric acid in humans". Current Clinical Pharmacology. 5 (1): 67–73. doi:10.2174/157488410790410588. PMID 19891605.

[1] Wishart, David S.; Guo, An Chi; Oler, Eponine; Wang, Fel; Anjum, Afia; Peters, Harrison; Dizon, Raynard; Sayeeda, Zinat; Tian, Siyang; Lee, Brian L.; Berjanskii, Mark; Mah, Robert; Yamamoto, Mai; Jovel Castillo, Juan; Torres Calzada, Claudia; Hiebert Giesbrecht, Mickel; Lui, Vicki W.; Varshavi, Dorna; Varshavi, Dorsa; Allen, Dana; Arndt, David; Khetarpal, Nitya; Sivakumaran, Aadhavya; Harford, Karxena; Sanford, Selena; Yee, Kristen; Cao, Xuan; Budinsky, Zachary; Liigand, Jaanus; Zhang, Lun; Zheng, Jiamin; Mandal, Rupasri; Karu, Naama; Dambrova, Maija; Schiöth, Helgi B.; Gautam, Vasuk. "Showing metabocard for Hippuric acid (HMDB0000714)". Human Metabolome Database, HMDB. 5.0.

[EB1911-2] One or more of the preceding sentences incorporates text from a publication now in the public domain: Chisholm, Hugh, ed. (1911). "Hippuric Acid". Encyclopædia Britannica. Vol. 13 (11th ed.). Cambridge University Press. p. 523.

[3] Pero, RW (2010). "Health consequences of catabolic synthesis of hippuric acid in humans". Current Clinical Pharmacology. 5 (1): 67–73. doi:10.2174/157488410790410588. PMID 19891605.

Hippuric acid information

and 27 Related for: Hippuric acid information

Hippuric acid

Benzoic acid

Glycolic acid

Glycine

Sodium benzoate

Shilajit

Xylene

Methylhippuric acid

Toluene toxicity

Aminohippuric acid

Quinic acid

Salicyluric acid

Phenylacetone

Acetophenone

Benzyl alcohol

Styrene oxide

Ethylbenzene

Benzyl benzoate

Alkaline diet

August Weismann

Amphetamine

Indian yellow

Phenylpropanolamine

Hexamethylenetetramine

Phenolic content in tea

Adderall

Drug metabolism

Names


IUPAC name N-Benzoylglycine
Preferred IUPAC name Benzamidoacetic acid
Other names Hippuric acid Benzoyl glycocoll Benzoyl amidoacetic acid
Identifiers
CAS Number	495-69-2^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:18089^Y
ChEMBL	ChEMBL461^Y
ChemSpider	451^Y
ECHA InfoCard	100.007.098
KEGG	C01586^Y
PubChem CID	464
UNII	TE0865N2ET^Y
CompTox Dashboard (EPA)	DTXSID9046073
InChI InChI=1S/C9H9NO3/c11-8(12)6-10-9(13)7-4-2-1-3-5-7/h1-5H,6H2,(H,10,13)(H,11,12)^Y Key: QIAFMBKCNZACKA-UHFFFAOYSA-N^Y InChI=1/C9H9NO3/c11-8(12)6-10-9(13)7-4-2-1-3-5-7/h1-5H,6H2,(H,10,13)(H,11,12) Key: QIAFMBKCNZACKA-UHFFFAOYAD
SMILES OC(=O)CNC(=O)c1ccccc1
Properties
Chemical formula	C₉H₉NO₃
Molar mass	179.175 g·mol⁻¹
Density	1.371 g/cm³
Melting point	187 to 188 °C (369 to 370 °F; 460 to 461 K)
Boiling point	240 °C (464 °F; 513 K) (decomposes)
Hazards
Safety data sheet (SDS)	Material Safety Data Sheet
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Y verify (what is ^YN ?) Infobox references