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Benzyl benzoate information


Benzyl benzoate
Clinical data
Trade namesAscabin, Ascabiol, Ascarbin, Tenutex, others
Other namesphenylmethyl ester, benzoic ester
ATC code
  • P03AX01 (WHO) QP53AX11 (WHO)
Identifiers
IUPAC name
  • Benzyl benzoate
CAS Number
  • 120-51-4
PubChem CID
  • 2345
DrugBank
  • DB02775
ChemSpider
  • 13856959
UNII
  • N863NB338G
KEGG
  • D01138
ChEBI
  • CHEBI:41237
ChEMBL
  • ChEMBL1239
CompTox Dashboard (EPA)
  • DTXSID8029153 Edit this at Wikidata
ECHA InfoCard100.004.003 Edit this at Wikidata
Chemical and physical data
FormulaC14H12O2
Molar mass212.248 g·mol−1
3D model (JSmol)
  • Interactive image
Density1.118 g/cm3 g/cm3
Melting point18 °C (64 °F)
Boiling point323 °C (613 °F)
Solubility in waterinsoluble mg/mL (20 °C)
SMILES
  • O=C(OCc1ccccc1)c2ccccc2
InChI
  • InChI=1S/C14H12O2/c15-14(13-9-5-2-6-10-13)16-11-12-7-3-1-4-8-12/h1-10H,11H2 checkY
  • Key:SESFRYSPDFLNCH-UHFFFAOYSA-N

Benzyl benzoate is an organic compound which is used as a medication and insect repellent.[1] As a medication it is used to treat scabies and lice.[2] For scabies either permethrin or malathion is typically preferred.[3] It is applied to the skin as a lotion.[2] Typically two to three applications are needed.[2] It is also present in Balsam of Peru, Tolu balsam, and in a number of flowers.[4]

Side effects may include irritation of the skin.[2] It is not recommended in children.[3] It is also used in other animals; however, it is considered toxic to cats.[1] How it works is unclear.[5]

Benzyl benzoate was first studied medically in 1918.[1] It is on the World Health Organization's List of Essential Medicines.[6] Benzyl benzoate is sold under the brand name Scabanca among others and is available as a generic medication.[1][3] It is not available for medical use in the United States.[1]

  1. ^ a b c d e Knowles CO (1991). "22.4.2 Benzyl Benzoate". In Hayes WJ, Laws ER (eds.). Handbook of Pesticide Toxicology, Volume 3: Classes of Pesticides. Academic Press. pp. 1505–1508. ISBN 0123341639.
  2. ^ a b c d World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 311. hdl:10665/44053. ISBN 9789241547659.
  3. ^ a b c British National Formulary: BNF 69 (69 ed.). British Medical Association. 2015. p. 836. ISBN 9780857111562.
  4. ^ Fahlbusch K, Hammerschmidt F, Panten J, Pickenhagen W, Schatkowski D, Bauer K, Garbe D, Surburg H (15 January 2003). "Flavors and Fragrances". Ullmann's Encyclopedia of Industrial Chemistry. Wiley. doi:10.1002/14356007.a11_141. ISBN 3527306730.
  5. ^ Bowman DD (2009). Georgis' Parasitology for Veterinarians. Elsevier Health Sciences. p. 262. ISBN 978-1416044123.
  6. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

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Benzyl benzoate

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Benzyl benzoate is an organic compound which is used as a medication and insect repellent. As a medication it is used to treat scabies and lice. For scabies...

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Denatonium

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several anions, such as benzoate or saccharinate. It can be obtained by the quaternization of lidocaine, a popular anesthetic, with benzyl chloride or a similar...

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perfume, and flavor industries. E.g. benzyl benzoate, benzyl salicylate, benzyl cinnamate, dibenzyl ether, benzyl butyl phthalate. It can be used as a...

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Ester

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reacts with sodium benzyloxide (generated from sodium and benzyl alcohol) to generate benzyl benzoate. The method is used in the production of ethyl acetate...

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Tolu balsam

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contains a fairly large amount of benzyl and cinnamyl esters of benzoic and cinnamic acid (benzyl benzoate, benzyl cinnamate). Balsam of Tolu is obtained...

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Benzyl group

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IUPAC nomenclature, the prefix benzyl refers to a C6H5CH2 substituent, for example benzyl chloride or benzyl benzoate. Benzyl is not to be confused with phenyl...

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Benzoic acid

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(2001). "Final Report on the Safety Assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate". Int J Tox. 20 (Suppl. 3): 23–50. doi:10.1080/10915810152630729...

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Sodium benzoate

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Sodium benzoate also known as benzoate of soda is the sodium salt of benzoic acid, widely used as a food preservative (with an E number of E211) and a...

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Sulfiram

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sold as a solution or medicated soap, sometimes in combination with benzyl benzoate. Sulfiram is now rarely used, but, as of 2015[update], is still available...

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Scabies

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treat onchocerciasis from 1987. Other treatments include lindane, benzyl benzoate, crotamiton, malathion, and sulfur preparations. Lindane is effective...

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Benzyl cinnamate

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Benzyl cinnamate is the chemical compound which is the ester derived from cinnamic acid and benzyl alcohol. Benzyl cinnamate occurs in Balsam of Peru and...

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Tishchenko reaction

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discovered by Claisen using sodium benzylate as base. The reaction produces benzyl benzoate. Enolizable aldehydes are not amenable to Claisen's conditions. Vyacheslav...

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Sudocrem

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(hypoallergenic) 4.00% emollient Benzyl benzoate, BP 1.01% vasodilation Benzyl alcohol, BP 0.39% mild anesthetic, disinfectant Benzyl cinnamate 0.15% antibacterial...

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with benzyl benzoate for solubilization and as a preservative, and is administered by intramuscular injection. As an excipient in Reandron 1000, benzyl benzoate...

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Kaempferia rotunda

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leaf are never seen at the same time. The flower contains the toxin benzyl benzoate used to make ointments to treat scabies. It has potential antioxidant...

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BAHD acyltransferase

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These are benzoyl-CoA:benzyl alcohol O-benzoyltransferase (PtBEBT) that produces benzyl benzoate from benzoyl-CoA and benzyl alcohol (Chedgy et al.,...

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Jasminum sambac

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benzoin Benzoin resin Benzophenone Benzyl alcohol Benzyl benzoate Benzyl butyrate Benzyl cinnamate Benzyl propionate Benzyl salicylate Bergamot oil Bisabolene...

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Jasminum grandiflorum

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and cosmetics worldwide. J. grandiflorum is composed of benzyl acetate (23.7%), benzyl benzoate (20.7%), phytol (10.9%), linalool (8.2%), isophytol (5...

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Balsam of Peru

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substances, including cinnamein, cinnamic acid, cinnamyl cinnamate, benzyl benzoate, benzoic acid, and vanillin. It also contains cinnamyl alcohol, cinnamaldehyde...

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Tetrahedral carbonyl addition compound

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precipitate which under acidic conditions yields benzyl benzoate, methyl benzoate, methanol, and benzyl alcohol. He named the likely common intermediate...

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should not be confused with benzyl, which has the formula −CH2−C6H5. The benzoyl group is given the symbol "Bz" whereas benzyl is commonly abbreviated "Bn"...

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nitroglycerin, ammonium nitrate, nitrocellulose fragrances and flavors benzyl benzoate, coumarin, vanillin industrial gases nitrogen, oxygen, acetylene, nitrous...

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