transcription initiation from RNA polymerase II promoter
positive regulation of transcription by RNA polymerase II
steroid hormone mediated signaling pathway
signal transduction
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7182
22026
Ensembl
ENSG00000177463
ENSMUSG00000005893
UniProt
P49116
P49117
RefSeq (mRNA)
NM_001291694 NM_003298
NM_011630 NM_001347342
RefSeq (protein)
NP_001278623 NP_003289
NP_001334271 NP_035760
Location (UCSC)
Chr 3: 14.95 – 15.05 Mb
Chr 6: 92.07 – 92.15 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Testicular receptor 4 also known as NR2C2 (nuclear receptor subfamily 2, group C, member 2) is a protein that in humans is encoded by the NR2C2 gene.[5][6][7]
The testicular receptor 4 is a member of the nuclear receptor family of transcription factors.
^ abcGRCh38: Ensembl release 89: ENSG00000177463 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000005893 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: NR2C2".
^Chang C, Da Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP (Jun 1994). "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily". Proceedings of the National Academy of Sciences of the United States of America. 91 (13): 6040–4. Bibcode:1994PNAS...91.6040C. doi:10.1073/pnas.91.13.6040. PMC 44133. PMID 8016112.
^Yoshikawa T, DuPont BR, Leach RJ, Detera-Wadleigh SD (Jul 1996). "New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene". Genomics. 35 (2): 361–6. doi:10.1006/geno.1996.0368. PMID 8661150.
and 24 Related for: Testicular receptor 4 information
Yong EL, Lamb DJ (January 2003). "Androgen receptor gene polyglutamine length is associated with testicular histology in infertile patients". J. Urol....
Testicular atrophy is a medical condition in which one or both testicles (or "testes") diminish in size and may be accompanied by reduced testicular function...
The testicularreceptor 2 (TR2) also known as NR2C1 (nuclear receptor subfamily 2, group C, member 1) is protein that in humans is encoded by the NR2C1...
In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain...
factor 4 alpha has been shown to interact with: Beta-catenin, CREB binding protein, MED1, MED14, Small heterodimer partner Testicularreceptor4, Hepatocyte...
develops a male phenotype. Synonyms for XX male syndrome include 46,XX testicular difference of sex development (or 46,XX DSD) In 90 percent of these individuals...
Unlike the androgen receptor (AR), a nuclear receptor which mediates its effects via genomic mechanisms, mARs are cell surface receptors which rapidly alter...
Spermatogenesis is defective with gene defects for the androgen receptor.[citation needed] Post-testicular azoospermia can be seen with certain point mutations in...
reduced capacity for the LH/hCG receptor to respond to LH. This results in hypoplasia or absence of Leydig cells, testicular atrophy, and lower than normal...
androgen receptor genes are highly implicated, as these are involved in penile development, testes descent, and testes development. Testicular germ cell...
estrogen receptors (ERα and ERβ), which are members of the nuclear receptor family of intracellular receptors, and membrane estrogen receptors (mERs) (GPER...
downregulation is the cellular decrease in the expression of a specific receptor in response to its increased activation by a molecule, such as a hormone...
Parl FF (2000). Estrogens, Estrogen Receptor and Breast Cancer. IOS Press. pp. 25–. ISBN 978-0-9673355-4-4. Norman AW, Henry HL (July 30, 2014). Hormones...
at time of diagnosis (around 25 years versus 35 years, in the case of testicular cancers), and have a lower five-year survival rate. The survival rate...
males as a testicular cancer, sometimes with skin hyperpigmentation (from excess chorionic gonadotropin cross reacting with the alpha MSH receptor), gynecomastia...
Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ERBB2 gene. ERBB is abbreviated...
and development, evaluation of testicular development and an assessment for masses that raise suspicion for testicular cancer, and proper development...
aromatase deficiency. Macroorchidism can be diagnosed by measuring the testicular volume using a prader orchidometer. There is no cure for macroorchidism...
hormone receptor is a receptor molecule that binds to a specific hormone. Hormone receptors are a wide family of proteins made up of receptors for thyroid...
plays a significant role in reproduction. ACVR2 receptors are present in the testis during testicular development. ACR2A and ACVR2B was found to be localized...
DMRT1 protein is located in the testicular cord and Sertoli cells, with a small amount in the germ cells. Defective testicular development and XY feminization...
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