PROX1 information

PROX1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LMD
Identifiers
Aliases	PROX1, prospero homeobox 1
External IDs	OMIM: 601546; MGI: 97772; HomoloGene: 2069; GeneCards: PROX1; OMA:PROX1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	214,041,510 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	189,902,911 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; liver; ; right lobe of liver; ; right ventricle; ; buccal mucosa cell; ; corpus callosum; ; biceps brachii; ; islet of Langerhans; ; Skeletal muscle tissue of biceps brachii; ; body of pancreas;
	Top expressed in
	lens; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; subthalamus; ; atrioventricular valve; ; nucleus reuniens; ; lumbar subsegment of spinal cord; ; Rostral migratory stream; ; white matter; ; aortic valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; transcription corepressor activity; DNA binding domain binding; DNA-binding transcription factor activity; LBD domain binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; core promoter sequence-specific DNA binding; protein binding; nuclear receptor binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	cytoplasm; nucleus;
Biological process	dorsal spinal cord development; olfactory placode formation; regulation of transcription, DNA-templated; positive regulation of endothelial cell proliferation; venous blood vessel morphogenesis; kidney development; lymphangiogenesis; lung development; dentate gyrus development; rhythmic process; ventricular septum morphogenesis; cardiac muscle cell differentiation; lymphatic endothelial cell differentiation; positive regulation of sarcomere organization; positive regulation of forebrain neuron differentiation; endocardium formation; hepatocyte differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of DNA-binding transcription factor activity; lymph vessel development; hepatocyte cell migration; transcription, DNA-templated; lens placode formation involved in camera-type eye formation; skeletal muscle thin filament assembly; neuronal stem cell population maintenance; positive regulation of endothelial cell migration; positive regulation of transcription, DNA-templated; positive regulation of heart growth; ventricular cardiac muscle tissue morphogenesis; positive regulation of neural precursor cell proliferation; retina morphogenesis in camera-type eye; multicellular organism development; negative regulation of viral genome replication; brain development; branching involved in pancreas morphogenesis; positive regulation of cell cycle; lens development in camera-type eye; response to nutrient levels; hepatocyte proliferation; positive regulation of cell cycle checkpoint; regulation of circadian rhythm; circadian rhythm; acinar cell differentiation; neural tube development; neuron differentiation; positive regulation of cell population proliferation; lens morphogenesis in camera-type eye; positive regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of bile acid biosynthetic process; embryonic retina morphogenesis in camera-type eye; regulation of gene expression; cell fate determination; pancreas development; liver development; atrial cardiac muscle tissue morphogenesis; endothelial cell differentiation; inner ear development; negative regulation of transcription, DNA-templated; ventricular cardiac myofibril assembly; otic placode formation; aorta smooth muscle tissue morphogenesis; cerebellar granule cell differentiation; negative regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; lens fiber cell morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	5629
	19130
	ENSG00000117707
	ENSMUSG00000010175
	Q92786
	P48437
	NM_001270616; NM_002763
	NM_008937; NM_001360827
	NP_001257545; NP_002754
	NP_032963; NP_001347756
	Wikidata
View/Edit Human	View/Edit Mouse

Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene.^[5]^[6] The Prox1 gene is critical for the development of multiple tissues. Prox1 activity is necessary and sufficient to specify a lymphatic endothelial cell fate in endothelial progenitors located in the embryonic veins.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117707 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000010175 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zinovieva RD, Duncan MK, Johnson TR, Torres R, Polymeropoulos MH, Tomarev SI (Dec 1996). "Structure and chromosomal localization of the human homeobox gene Prox 1". Genomics. 35 (3): 517–22. doi:10.1006/geno.1996.0392. PMID 8812486.
^ "Entrez Gene: PROX1 prospero-related homeobox 1".
^ Harvey, Natasha L (October 2005). "Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity". Nature Genetics. 37 (10): 1072–1081. doi:10.1038/ng1642. PMID 16170315. S2CID 25103068.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117707 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000010175 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8812486-5] Zinovieva RD, Duncan MK, Johnson TR, Torres R, Polymeropoulos MH, Tomarev SI (Dec 1996). "Structure and chromosomal localization of the human homeobox gene Prox 1". Genomics. 35 (3): 517–22. doi:10.1006/geno.1996.0392. PMID 8812486.

[entrez-6] "Entrez Gene: PROX1 prospero-related homeobox 1".

[7] Harvey, Natasha L (October 2005). "Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity". Nature Genetics. 37 (10): 1072–1081. doi:10.1038/ng1642. PMID 16170315. S2CID 25103068.

PROX1 information

and 14 Related for: PROX1 information

PROX1

Guillermo Oliver

Lymph sacs

Meningeal lymphatic vessels

Lymphangiogenesis

List of human transcription factors

Lymphangioleiomyomatosis

EP300

Subgranular zone

Ganglion mother cell

GATA2 deficiency

FOXE3

TCF7L2

TMEM247