Halothane, sold under the brand name Fluothane among others, is a general anaesthetic.[5] It can be used to induce or maintain anaesthesia.[5] One of its benefits is that it does not increase the production of saliva, which can be particularly useful in those who are difficult to intubate.[5] It is given by inhalation.[5]
Side effects include an irregular heartbeat, respiratory depression, and hepatotoxicity.[5] Like all volatile anesthetics, it should not be used in people with a personal or family history of malignant hyperthermia.[5] It appears to be safe in porphyria.[6] It is unclear whether its usage during pregnancy is harmful to the fetus, and its use during a C-section is generally discouraged.[7] Halothane is a chiral molecule that is used as a racemic mixture.[8]
Halothane was discovered in 1951.[9] It was approved for medical use in the United States in 1958.[3] It is on the World Health Organization's List of Essential Medicines.[10] Its use in developed countries has been mostly replaced by newer anesthetic agents such as sevoflurane.[11] It is no longer commercially available in the United States.[7] Halothane also contributes to ozone depletion.[12][13]
^Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^"Halothane, USP". DailyMed. 18 September 2013. Retrieved 11 February 2022.
^ ab"Fluothane: FDA-Approved Drugs". U.S. Food and Drug Administration. Retrieved 12 February 2022.
^"Halothane". DrugBank. DB01159.
^ abcdefWorld Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 17–8. hdl:10665/44053. ISBN 9789241547659.
^James MF, Hift RJ (July 2000). "Porphyrias". British Journal of Anaesthesia. 85 (1): 143–53. doi:10.1093/bja/85.1.143. PMID 10928003.
^ ab"Halothane - FDA prescribing information, side effects and uses". www.drugs.com. June 2005. Archived from the original on 21 December 2016. Retrieved 13 December 2016.
^Bricker S (17 June 2004). The Anaesthesia Science Viva Book. Cambridge University Press. p. 161. ISBN 9780521682480. Archived from the original on 10 September 2017 – via Google Books.
^Walker SR (2012). Trends and Changes in Drug Research and Development. Springer Science & Business Media. p. 109. ISBN 9789400926592. Archived from the original on 10 September 2017.
^World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
^Yentis SM, Hirsch NP, Ip J (2013). Anaesthesia and Intensive Care A-Z: An Encyclopedia of Principles and Practice (5th ed.). Elsevier Health Sciences. p. 264. ISBN 9780702053757. Archived from the original on 10 September 2017.
^Kümmerer K (2013). Pharmaceuticals in the Environment: Sources, Fate, Effects and Risks. Springer Science & Business Media. p. 33. ISBN 9783662092590.
^Langbein T, Sonntag H, Trapp D, Hoffmann A, Malms W, Röth EP, et al. (January 1999). "Volatile anaesthetics and the atmosphere: atmospheric lifetimes and atmospheric effects of halothane, enflurane, isoflurane, desflurane and sevoflurane". British Journal of Anaesthesia. 82 (1): 66–73. doi:10.1093/bja/82.1.66. PMID 10325839.
Halothane, sold under the brand name Fluothane among others, is a general anaesthetic. It can be used to induce or maintain anaesthesia. One of its benefits...
or an analogue thereof, such as 3-methylfentanil, and the anaesthetic halothane. Foreign embassies in Moscow issued official requests for more information...
most common triggering agents are volatile anesthetic gases, such as halothane, sevoflurane, desflurane, isoflurane, enflurane or the depolarizing muscle...
agreed to allow Paul to have sex with Tammy. She obtained a bottle of Halothane (a liquid general anesthetic) from the veterinary clinic where she worked...
breakdown product of the volatile anaesthetic agent halothane. It is thought to be responsible for halothane induced hepatitis. No known natural processes generate...
properties imply that anaesthesia can be induced more rapidly than with halothane, its pungency can irritate the respiratory system, negating any possible...
general anesthetic, until non-flammable drugs were developed, such as halothane. It has been used as a recreational drug to cause intoxication. Most diethyl...
Cyclopropane Diethyl ether Divinyl ether Enflurane Ethylene Fluroxene Halothane (still widely used in the developing world and is on the WHO Model List...
hepatotoxicity as had been found with chloroform. The introduction of halothane in 1956 greatly diminished the use of TCE as a general anesthetic. TCE...
anesthetic. It is an anesthetic with effects related to isoflurane and halothane. Chlorobutanol is toxic to the liver, a skin irritant and a severe eye...
medicine. Together with desflurane, sevoflurane is replacing isoflurane and halothane in modern anesthesia practice. It is often administered in a mixture of...
At ~1 MAC halothane, reported minor changes in tubulin protein expression (~1.3-fold) in primary cortical neurons after exposure to halothane and isoflurane...
toxic) halogenated hydrocarbons such as chloroform and trichloroethylene. Halothane is another halogenated hydrocarbon anesthetic agent which was introduced...
superseded d-tubocurarine for anesthesia during surgery. When used with halothane d-tubocurarine can cause a profound fall in blood pressure in some patients...
meaty and efficient breed". The breed is unusually responsive to the halothane test, which can be used to weed out individuals with low projected survivability...
plenum vaporizer was the Cyprane 'FluoTEC' Halothane vaporizer, released onto the market shortly after Halothane was introduced into clinical practice in...
but Claire discovers he dialed 4-1-1 instead. He paralyzes her with halothane, admitting that he murdered Madison when she threatened to expose their...
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