Bumetanide, sold under the brand name Bumex among others, is a medication used to treat swelling and high blood pressure.[2] This includes swelling as a result of heart failure, liver failure, or kidney problems.[2] It may work for swelling when other medications have not.[2] For high blood pressure it is not a preferred treatment.[2] It is taken by mouth, or by injection into a vein or muscle.[2] Effects generally begin within an hour and last for about six hours.[2]
Common side effects include dizziness, low blood pressure, low blood potassium, muscle cramps, and kidney problems.[2] Other serious side effects may include hearing loss and low blood platelets.[2] Blood tests are recommended regularly for those on treatment.[2] Safety during pregnancy and breastfeeding is unclear.[3] Bumetanide is a loop diuretic and works by decreasing the reabsorption of sodium by the kidneys.[4][2]
Bumetanide was patented in 1968 and came into medical use in 1972.[5] It is on the World Health Organization's List of Essential Medicines.[6] It is available as a generic medication.[4] In 2020, it was the 270th most commonly prescribed medication in the United States, with more than 1million prescriptions.[7][8]
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ abcdefghij"Bumetanide Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 8 April 2019.
^"Bumetanide (Bumex) Use During Pregnancy". Drugs.com. Retrieved 8 April 2019.
^ abBritish national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 225–226. ISBN 978-0-85711-338-2.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 458. ISBN 978-3-527-60749-5.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
^"The Top 300 of 2020". ClinCalc. Retrieved 7 October 2022.
^"Bumetanide - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.
Bumetanide, sold under the brand name Bumex among others, is a medication used to treat swelling and high blood pressure. This includes swelling as a result...
potent as an equivalent dose taken orally. However, for torsemide and bumetanide, their oral bioavailability is consistently higher than 90%. Torsemide...
L (April 1995). "Mineral excretion following furosemide compared with bumetanide therapy in premature infants". Pediatr. Nephrol. 9 (2): 159–62. doi:10...
is sometimes used together with loop diuretics such as furosemide or bumetanide, but these highly effective combinations can lead to dehydration and electrolyte...
harder to identify them. Examples of diuretics and masking agents are bumetanide, chlorothiazide, furosemide, hydrochlorothiazide, probenecid, spironolactone...
Alternatives are 4th level ATC chemical subgroup (C09AA ACE inhibitors, plain) Bumetanide and torasemide are alternatives For use in high‐risk patients. Atorvastatin...
furosemide is added at a dose of 40 mg/day (max 160 mg/day), or alternatively (bumetanide or torasemide). The ratio of 100:40 reduces risks of potassium imbalance...
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