High magnification micrograph showing liver cholestasis.
Specialty
Obstetrics
Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, cholestasis of pregnancy, jaundice of pregnancy, and prurigo gravidarum,[1] is a medical condition in which cholestasis occurs during pregnancy. It typically presents with itching[2] and can lead to complications for both mother and fetus.
Pruritus (itching) is a common symptom of pregnancy, affecting around 23% of women.[3] The majority of times, itching is a minor annoyance caused by changes to the skin, especially that of the abdomen. However, there are instances when itching may be a symptom of ICP. Although typically noticed on the palms of the hands and the soles of the feet, the itching can occur anywhere on the body.
ICP occurs most commonly in the third trimester, but can begin at any time during the pregnancy.
^Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
^Tunzi M, Gray GR (January 2007). "Common skin conditions during pregnancy". American Family Physician. 75 (2): 211–8. PMID 17263216.
^Kenyon, AP; Tribe, RM; Nelson-Piercy, C; Girling, JC; Williamson, C; Seed, PT; Vaughn-Jones, S; Shennan, AH (2010). "Pruritus in pregnancy: A study of anatomical distribution and prevalence in relation to the development of obstetric cholestasis". Obstetric Medicine. 3 (1): 25–29. doi:10.1258/om.2010.090055. PMC 4989767. PMID 27582836.
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