Micrograph of a juvenile granulosa cell tumour with hyaline globules. H&E stain.
Specialty
Gynecologic oncology, obstetrics and gynaecology, oncology, endocrinology
Granulosa cell tumours are tumours that arise from granulosa cells. They are estrogen secreting tumours and present as large, complex, ovarian masses. These tumours are part of the sex cord–gonadal stromal tumour or non-epithelial group of tumours. Although granulosa cells normally occur only in the ovary, granulosa cell tumours occur in both ovaries and testicles (see ovarian cancer and testicular cancer). These tumours should be considered malignant and treated in the same way as other malignant tumours of ovary. The ovarian disease has two forms, juvenile and adult, both characterized by indolent growth,[1] and therefore has high recovery rates.[2][3] The staging system for these tumours is the same as for epithelial tumours and most present as stage I.[4] The peak age at which they occur is 50–55 years, but they may occur at any age.
Juvenile granulosa cell tumour is a similar but histologically distinct rare tumour. It too occurs in both the ovary and testis. In the testis it is extremely rare, and has not been reported to be malignant.[5] Although this tumour usually occurs in children (hence its name), it has been reported in adults.[6]
^"Prognostic factors in adult granulosa".
^Young RH, Dickersin GR, Scully RE (1984). "Juvenile granulosa cell tumor of the ovary. A clinic pathological analysis of 125 cases. Beth Israel Deaconess Medical Center, Boston". American Journal of Surgical Pathology. 8 (8): 575–596. doi:10.1097/00000478-198408000-00002. PMID 6465418. S2CID 25845267.
^"Program in Gynecologic Medical Oncology, Beth Israel Deaconess Medical Center, Boston".
^Gynaecology. 3rd Ed. 2003. Churchill Livingstone, pp. 690-691.
^Dudani R, Giordano L, Sultania P, Jha K, Florens A, Joseph T (April 2008). "Juvenile granulosa cell tumor of testis: case report and review of literature". American Journal of Perinatology. 25 (4): 229–231. doi:10.1055/s-2008-1066878. PMID 18548396.
^Lin KH, Lin SE, Lee LM (July 2008). "Juvenile granulosa cell tumor of adult testis: a case report". Urology. 72 (1): 230.e11–3. doi:10.1016/j.urology.2007.11.126. PMID 18313118.
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