X-ray image showing enchondromas localized in the lower part of the radius of a 7-year-old girl with Ollier disease.
Specialty
Medical genetics
Ollier disease is a rare sporadic nonhereditary skeletal disorder in which typically benign cartilaginous tumors (enchondromas) develop near the growth plate cartilage. This is caused by cartilage rests that grow and reside within the metaphysis or diaphysis and eventually mineralize over time to form multiple enchondromas.[1] Key signs of the disorder include asymmetry and shortening of the limb as well as an increased thickness of the bone margin. These symptoms are typically first visible during early childhood with the mean age of diagnosis being 13 years of age.[2] Many patients with Ollier disease are prone to develop other malignancies including bone sarcomas that necessitate treatment and the removal of malignant bone neoplasm. Cases in patients with Ollier disease has shown a link to IDH1, IDH2, and PTH1R gene mutations. Currently, there are no forms of treatment for the underlying condition of Ollier disease but complications such as fractures, deformities, malignancies that arise from it can be treated through surgical procedures. The prevalence of this condition is estimated at around 1 in 100,000.[3] It is unclear whether the men or women are more affected by this disorder due to conflicting case studies.
^Muthusamy, Saravanaraja; Conway, Sheila A.; Temple, H. Thomas (July 2014). "Five Polyostotic Conditions That General Orthopedic Surgeons Should Recognize (or Should Not Miss)". Orthopedic Clinics of North America. 45 (3): 417–429. doi:10.1016/j.ocl.2014.04.004. ISSN 0030-5898. PMID 24975767.
^Verdegaal, Suzan H.M.; Bovée, Judith V.M.G.; Pansuriya, Twinkal C.; Grimer, Robert J.; Ozger, Harzem; Jutte, Paul C.; San Julian, Mikel; Biau, David J.; van der Geest, Ingrid C.M.; Leithner, Andreas; Streitbürger, Arne (December 2011). "Incidence, Predictive Factors, and Prognosis of Chondrosarcoma in Patients with Ollier Disease and Maffucci Syndrome: An International Multicenter Study of 161 Patients". The Oncologist. 16 (12): 1771–1779. doi:10.1634/theoncologist.2011-0200. ISSN 1083-7159. PMC 3248776. PMID 22147000.
Ollierdisease is a rare sporadic nonhereditary skeletal disorder in which typically benign cartilaginous tumors (enchondromas) develop near the growth...
disorders: Ollierdisease, Maffucci syndrome, and metachondromatosis. It is important to make the distinction between these diseases, particularly Ollier disease...
(1830–1900), surgeon Patrick Ollier (born 1944), politician Rémy Ollier (1816–1845), Mauritan activist Ollierdisease, disease of cartilage This page lists...
multiple enchondromas is consistent with multiple enchondromatosis (OllierDisease). Treatment of enchondromas involves surgical curettage and grafting...
/ˌɒstioʊˈdʒɛnəsɪs ˌɪmpɜːrˈfɛktə/; OI), colloquially known as brittle bone disease, is a group of genetic disorders that all result in bones that break easily...
following:[citation needed] Ollierdisease (enchondromatosis) – when multiple sites in the body develop the tumors. Ollierdisease is very rare. Maffucci's...
secondary chondrosarcomas occur in people with Maffucci syndrome and Ollierdisease. It has been associated with faulty isocitrate dehydrogenase 1 and 2...
Somatic mosaic mutations of this gene have also been found associated to Ollierdisease and Maffucci syndrome. However, recent studies have also shown that...
enchondromas. Ollierdisease can be considered a synonym for enchondromatosis. Maffucci syndrome is enchondromatosis with hemangiomatosis. "Ollierdisease" at Dorland's...
Somatic mosaic mutations of this gene have also been found associated to Ollierdisease and Maffucci syndrome. Isocitrate dehydrogenase is composed of 3 subunits...
with exostoses and Ollierdisease. The observation of one family with five affected people led to the identification of the disease as autosomal dominant...
disorder, also predisposes women to sex cord tumour with annular tubules. Ollierdisease and Maffucci syndrome are associated with granulosa cell tumors in children...
Mutschler W (July 2005). "The management of leg-length discrepancy in Ollier'sdisease with a fully implantable lengthening nail". The Journal of Bone and...
Mosby. ISBN 1-4160-2999-0. James, William D.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0...
Forensic Sciences. 40 (5): 888–892. doi:10.1520/JFS15404J. PMID 7595333. Ollier W, Doyle P, Alonso A, Awad J, Williams E, Gill D, et al. (February 1985)...
Biathlon. Floriet was born in 1963 and was found to have Ollierdisease which is a non hereditary disease that effects bone structure. Floriet competed at the...
called "Poncet's disease". Following the assassination of Marie François Sadi Carnot in Lyon on 24 June 1894, Drs. Poncet and Ollier attended to the wounded...
ISBN 978-3-8047-1763-3. Payne K, Newman W, Fargher E, Tricker K, Bruce IN, Ollier WE (May 2007). "TPMT testing in rheumatology: any better than routine monitoring...
Neil; Ollier, William E.; Carter, Stuart D. (2009). "Genome-wide association analysis of canine atopic dermatitis and identification of disease related...
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