Reinke crystals are rod-like cytoplasmic inclusions which can be found in Leydig cells of the testes.[1] Occurring only in adult humans and wild bush rats, their function is unknown.[2]
Ovarian stromal tumors having a predominant pattern of fibroma or thecoma but also containing cells typical of steroid hormone-secreting cells were reported. Some of the tumors were classified as luteinized thecomas because the steroid cells resembled lutein cells and lacked crystalloids of Reinke. Others were classified as stromal Leydig cell tumors as seen in tumors of the testes because Reinke crystalloids were identified in the steroid cells. The stromal Leydig tumors occurred at an average age of 61 years and were associated with ovarian hyperandrogenism which led to virilization in some cases, endometrial hyperplasia in other cases, and endometrial hyperplasia with carcinoma in the rest of the cases. Luteinized thecomas and stromal Leydig cell tumors are indistinguishable except for the presence of crystalloids of Reinke in the latter. In view of the prolonged search that is necessary to find these structures in some stromal Leydig cell tumors and their well-known absence in the majority of testicular Leydig cell tumors, it is reasonable to assume that an unknown proportion of tumors in the luteinized thecoma category are unrecognized stromal Leydig cell tumors.[3][4][5]
Another ovarian tumor where Reinke crystalloids were noted is the Brenner tumour, an epithelial-stromal ovarian tumor distinguishable by nests of transitional epithelial cells (urothelial) with longitudinal nuclear grooves (coffee bean nuclei) in abundant fibrous stroma.[6][7]
Also recall that the "coffee bean nuclei" are the nuclear grooves exceptionally pathognomonic to the sex cord stromal tumor, the ovarian granulosa cell tumor, with the fluid-filled spaces Call–Exner bodies between the granulosa cells.[8]
They are large enough to be seen in an optical microscope and can be visualized using Giemsa, trichrome, Gram, and PAS stains.[9] Reinke crystals are rare in normal testes, but are found in approximately one third of all Leydig cell tumours.[10]
These crystals are named after the German anatomist Friedrich Berthold Reinke.[11]
^Young, Barbara; Woodford, Phillip; O'Dowd, Geraldine (2013-10-09). Wheater's Functional Histology: A Text and Colour Atlas (FUNCTIONAL HISTOLOGY (WHEATER'S)) (Kindle Locations 9938-9939). Elsevier Health Sciences UK. Kindle Edition.
^Young, Barbara; Woodford, Phillip; O'Dowd, Geraldine. Wheater's Functional Histology: A Text and Colour Atlas (2014), Sixth Edition, Elsevier, Philadelphia, p. 344.
^Zhang, J; Young, RH; Arseneau, J; Scully, RE (1982). "Ovarian stromal tumors containing lutein or Leydig cells (luteinized thecomas and stromal Leydig cell tumors)--a clinicopathological analysis of fifty cases". Int J Gynecol Pathol. 1 (3): 270–85. doi:10.1097/00004347-198203000-00004. PMID 6309683.
^Zhang, J.; Young, R. H.; Arseneau, J.; Scully, R. E. (1982). "Ovarian stromal tumors containing lutein or Leydig cells (luteinized thecomas and stromal Leydig cell tumors)--a clinicopathological analysis of fifty cases". International Journal of Gynecological Pathology. 1 (3): 270–285. doi:10.1097/00004347-198203000-00004. ISSN 0277-1691. PMID 6309683. S2CID 22113962.
^Sood, Neelam; Nigam, Jitendra Singh; Goyal, Geetika; Ranjan, Reeta (2014-08-12). "Virilizing Ovarian Fibrothecoma with Minor Sex Cord Elements in a 13 Year Old Girl: a Rare Case". Pediatric Reports. 6 (3): 5447. doi:10.4081/pr.2014.5447. ISSN 2036-749X. PMC 4292058. PMID 25635214.
^Ahr, A.; Arnold, G.; Göhring, U. J.; Costa, S.; Scharl, A.; Gauwerky, J. F. (July 1997). "Cytology of ascitic fluid in a patient with metastasizing malignant Brenner tumor of the ovary. A case report". Acta Cytologica. 41 (4 Suppl): 1299–1304. doi:10.1159/000333524. ISSN 0001-5547. PMID 9990262.
^Hector, Mesa; Scott, Gilles; Sophia, Smith; Susan, Dachel; Wendy, Larson; Carlos, Manivel J. (2015). "The Mystery of the Vanishing Reinke Crystals". Human Pathology. 46: 600–606. doi:10.1016/j.humpath.2015.01.004.
^T. M. Ulbright and R. H. Young. AFIP Atlas of tumour pathology. Tumours of the testis and adjacent structures. Fourth series fascicle 18, Silver Spring, Maryland: ARP Press, 2013, p. 271–286.
^"Friedrich Berthold Reinke". Whonamedit.com. Retrieved 12 February 2015.
Reinkecrystals are rod-like cytoplasmic inclusions which can be found in Leydig cells of the testes. Occurring only in adult humans and wild bush rats...
mitochondria are also prominent within the cytoplasm. Reinkecrystals have lipofuscin pigment and rod-shaped crystal-like structures 3 to 20 micrometres in diameter...
Friedrich Reinke (11 April 1862 – 12 May 1919) was a German anatomist. Reinkecrystals, Reinke's space and Reinke's edema are named after him. Friedrich...
hyperandrogenism and virilization) both have characteristic Reinkecrystals. The same crystals were also noted under high-power view in Brenner tumours....
histology, as part of a pathology report made during or after surgery. Reinkecrystals are classically found in these tumours and help confirm the diagnosis...
reduced to a mechanistic process. Vitalist biologists such as Johannes Reinke proposed testable hypotheses meant to show inadequacies with mechanistic...
original on 4 February 2014. Miller 2004, p. 103. Miller 2004, p. 107. Reinke, Stefan; Goh, Kerstin (16 November 2011). "Erasure im Soundcheck". Westdeutsche...
either lack calcium oxalate crystals and have a brown pigmentation or be colourless, shorter, and densely covered in these crystals. The symbiotic partner...
Kimmelot Tough Crowd with Colin Quinn 2002–2004 Comedy Central Gerhard Reinke's Wanderlust 2003 co-production with Jackhole Productions Chappelle's Show...
didn't kill the tigers because they were sick...He allegedly blew up John Reinke's cabin and golf cart...Lowe says he never set up Joe Exotic...Joe Exotic...
21491–4. doi:10.1074/jbc.274.31.21491. PMID 10419448. Bläser J, Triebel S, Reinke H, Tschesche H (1992). "Formation of a covalent Hg-Cys-bond during mercurial...
the introduction of blue laser beam backlights with a yellow phosphor crystal lens complementing the LED headlights, a revised V6 TDI engine with an...
Bustad Chris Casto Jackson Cates Noah Cates Casey Nelson Tom Porter Mitch Reinke Sturgeon Lake Clay Wilson Thief River Falls Robert Baker Michael Forney...
slide from a range of solvents and the formation of crystals with characteristic shapes; the crystals are examined microscopically for identification. Although...
Retrieved 17 March 2019. "Playing Lego with 2D crystals: exfoliation and intercalation strategies to put 2D crystals on surfaces and to produce pillared structures"...
lower chance of dying each year". New Scientist. Retrieved 18 July 2022. Reinke, Beth A.; Cayuela, Hugo; Janzen, Fredric J.; et al. (24 June 2022). "Diverse...
1432-1033.1997.0590a.x. PMID 9428714. Laussermair E, Schwarz E, Oesterhelt D, Reinke H, Beyreuther K, Dimroth P (September 1989). "The sodium ion translocating...
June 2020. Refer: "Australian Antarctic Medal (AAM) entry for Andrew Jason Reinke". Australian Honours Database. Canberra, Australia: Department of the Prime...
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