positive regulation of prostaglandin-endoperoxide synthase activity
hormonal regulation of the force of heart contraction
regulation of systemic arterial blood pressure by endothelin
vasoconstriction
cytokine-mediated signaling pathway
positive regulation of cytosolic calcium ion concentration
neutrophil chemotaxis
positive regulation of heart rate
positive regulation of leukocyte chemotaxis
cell surface receptor signaling pathway
vein smooth muscle contraction
macrophage chemotaxis
regulation of vasoconstriction
positive regulation of cell population proliferation
artery smooth muscle contraction
energy homeostasis
macrophage activation
prostaglandin biosynthetic process
lung alveolus development
temperature homeostasis
positive regulation of the force of heart contraction by chemical signal
inositol phosphate-mediated signaling
positive regulation of smooth muscle contraction
calcium-mediated signaling
regulation of signaling receptor activity
G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1907
13615
Ensembl
ENSG00000127129
ENSMUSG00000028635
UniProt
P20800
P22389
RefSeq (mRNA)
NM_001956 NM_001302269
NM_007902
RefSeq (protein)
NP_001289198 NP_001947
NP_031928
Location (UCSC)
Chr 1: 41.48 – 41.48 Mb
Chr 4: 120.02 – 120.02 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Endothelin 2 (ET-2) is a protein encoded by the EDN2 gene in humans. It was first discovered in 1988 by Yanagisawa and team[5] and belongs to a family of three endothelin peptide isoforms (ET-1, ET-2, ET-3), which constrict blood vessels. ET-2 is encoded by genes on separate chromosomes to its isoforms and is mainly produced in vascular endothelial cells of the kidney, placenta, uterus, heart, central nervous system and intestine.[6] It becomes present in the blood of animals and humans at levels ranging from 0.3pg/ml to 3pg/ml.[7] ET-2 acts by binding to two different G-protein coupled receptors (GPCRs), the endothelin A receptor (EDNRA) and the endothelin B receptor (EDNRB).[8]
^ abcGRCh38: Ensembl release 89: ENSG00000127129 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000028635 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, et al. (March 1988). "A novel potent vasoconstrictor peptide produced by vascular endothelial cells" (PDF). Nature. 332 (6163): 411–5. Bibcode:1988Natur.332..411Y. doi:10.1038/332411a0. hdl:2241/1639. PMID 2451132. S2CID 4308549.
^Vatta MS, Bianciotti LG, Guil MJ, Hope SI (2015). "Regulation of the norepinephrine transporter by endothelins: a potential therapeutic target". Vitamins and Hormones. 98: 371–405. doi:10.1016/bs.vh.2014.12.013. hdl:11336/38984. ISBN 978-0-12-803008-0. PMID 25817875.
^Cite error: The named reference Ling et al 2013 was invoked but never defined (see the help page).
^Nakas-Ićindić E, Zaciragić A, Hadzović A, Avdagić N (July 2004). "Endothelin in health and disease". Bosnian Journal of Basic Medical Sciences. 4 (3): 31–4. doi:10.17305/bjbms.2004.3381. PMC 7245481. PMID 15629009.
genes for endothelin-1 (ET-1), endothelin-2 (ET-2), and endothelin-3 (ET-3) are located on chromosomes 6, 1, and 20, respectively. Endothelin functions...
Endothelin2 (ET-2) is a protein encoded by the EDN2 gene in humans. It was first discovered in 1988 by Yanagisawa and team and belongs to a family of...
is proteolytically processed to release endothelin 1. Endothelin 1 is one of three isoforms of human endothelin. Preproendothelin is precursor of the peptide...
Endothelin-3 is a protein that in humans is encoded by the EDN3 gene. The protein encoded by this gene is a member of the endothelin family. Endothelins...
Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1), -2 (EDN2), and -3 (EDN3) to biologically active peptides. GRCh38:...
taken by mouth. Aprocitentan is a dual endothelin-1 antagonist that targets both endothelin A and endothelin B receptors. Aprocitentan was approved for...
Endothelin receptor type B, (ET-B) is a protein that in humans is encoded by the EDNRB gene. Endothelin receptor type B is a G protein-coupled receptor...
against the cold), calcium antagonists, endovenous prostaglandins or endothelin-2 antagonists may be useful. In patients with gastroesophageal reflux,...
Endothelin receptor type A, also known as ETA, is a human G protein-coupled receptor. Endothelin receptor type A has been shown to interact with HDAC7A...
Macitentan, sold under the brand name Opsumit, is an endothelin receptor antagonist (ERA) developed by Actelion and approved for the treatment of pulmonary...
There are at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC, all of which are G protein-coupled receptors whose activation result in elevation...
therapeutic targets for patients with prediabetes or Type 2 diabetes mellitus. Oxytocin (OXT) Omentin Endothelin-1 Nesfatin-1 Irisin Betatrophin Hepatocyte growth...
Duplication of endothelin 3 Is Closely Correlated with the Hyperpigmentation of the Internal Organs (Fibromelanosis) in Silky Chickens". Genetics. 190 (2): 627–638...
the treatment of pulmonary hypertension. It is an endothelin receptor antagonist. The peptide endothelin constricts muscles in blood vessels, increasing...
Bosentan, sold under the brand name Tracleer among others, is a dual endothelin receptor antagonist medication used in the treatment of pulmonary artery...
decrease collagen degradation and increase extracellular matrix production. Endothelin signalling is implicated in the pathophysiology of fibrosis. Vitamin D...
activity) decreases. Endothelin-1 is a peptide (comprising 21 amino acids) that is produced in endothelial cells. It acts on the endothelin receptors ETA and...
of endothelin (ET) on the endothelin-A (ETA) receptor selectively (by a factor of 6000 compared with the ETB). It is a sulfonamide class endothelin receptor...
the brand name Tyvalzi) is a synthetic analog of endothelin-1 that works as a selective endothelin-B receptor agonist. In May 2023, it was approved in...
sympathetic drive in hypertension include reactive oxygen species and endothelin. Some studies have shown that hypertensive patients manifest greater vasoconstrictor...
vasoconstrictive properties of endothelin and are mainly used for the treatment of pulmonary arterial hypertension, atrasentan blocks endothelin induced cell proliferation...
the treatment of primary immunoglobulin A nephropathy. Sparsentan is an endothelin and angiotensin II receptor antagonist. It is taken by mouth. It was approved...
The cannabinoid receptor 2 (CB2), is a G protein-coupled receptor from the cannabinoid receptor family that in humans is encoded by the CNR2 gene. It...
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