GRAM domain containing 1A also known as Aster-A is a protein that is encoded by the GRAMD1A gene.
[5][6] It contains a transmembrane region, a GRAM domain and a VASt domain that can bind cholesterol.[7][8] GRAMD1A has four paralogs: GRAMD1B and GRAMD1C and two without VASt domains, GRAMD2A and GRAMD2B. These proteins are mammalian representatives of the yeast lipid transfer proteins anchored at a membrane contact site (LAM) family.[7]
The protein is expressed ubiquitously with higher levels in the central nervous system.[9]
^ abcGRCh38: Ensembl release 89: ENSG00000089351 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000001248 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"UniProtKB - Q8VEF1 (ASTRA_MOUSE)". Retrieved March 6, 2020.
^ abBesprozvannaya M, Dickson E, Li H, Ginburg KS, Bers DM, Auwerx J, Nunnari J (February 2018). "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells". eLife. 22 (7): e31019. doi:10.7554/eLife.31019. PMC 5823543. PMID 29469807.
^Sandhu J, Li S, Fairall L, Pfisterer SG, Gurnett JE, Xiao X, Weston TA, Vashi D, Ferrari A, Orozco JL, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, Jiang H, Bentolila LA, Gatta AT, Levine TP, Ferng A, Lee R, Ford DA, Young SG, Ikonen E, Schwabe JW, Tontonoz P (October 2018). "Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells". Cell. 175 (2): 514–529.e20. doi:10.1016/j.cell.2018.08.033. PMC 6469685. PMID 30220461.
proteins are eukaryotic transcription factors containing a bipartite DNA binding domain referred to as the POU domain. The various members of the POU family...
domain, and cluster of basic residues on the cytosolic face at the protein's extreme C-terminus. The PEP-CTERM/exosortase system, found in many Gram-negative...
other flavoproteins. The FMN binding domain is homologous to flavodoxins, and the two domain fragment containing the FAD and NADPH binding sites is homologous...
cytoplasmic domains of CD3 to amplify the signal generated by the TCR. Phosphorylated ITAMs on CD3 recruit and activate SH2 domain-containing protein tyrosine...
of E. coli and other gram-negative rod-shaped bacteria, the "housekeeping" sigma factor is σ70. Genes recognized by σ70 all contain similar promoter consensus...
mycelia contain some psilocybin, while young mycelia (recently germinated from spores) lack appreciable amounts. Many species of mushrooms containing psilocybin...
for a combination drug called mixed amphetamine salts (“MAS” products) containing four salts of amphetamine. The mixture is composed of equal parts racemic...
Shigella flexneri is a species of Gram-negative bacteria in the genus Shigella that can cause diarrhea in humans. Several different serogroups of Shigella...
than the females. The female's mass can reach around 10 grams and the male is about 6 grams. The head and dorsal surface are pinkish-brown with darker...
intracellular tyrosine-based switch motives (ITSMs) that interact with SH2 domain-containing proteins. However, nCD150 intracellular region differs from other...
Oxalobacter formigenes is a Gram negative oxalate-degrading anaerobic bacterium that was first isolated from the gastrointestinal tract of a sheep in 1985...
In mathematics, symmetric cones, sometimes called domains of positivity, are open convex self-dual cones in Euclidean space which have a transitive group...
glutamate. ... DHK-sensitive, EAAT2 uptake was not altered by AMPH (Figure 1A). The remaining glutamate transport in these midbrain cultures is likely mediated...
domain as pFAM01769 and additionally identifies a MgtE domain-containing protein in Drosophila melanogaster. The proteins containing the MgtE domain can...
PR domain zinc finger protein 1, or B lymphocyte-induced maturation protein-1 (BLIMP-1), is a protein in humans encoded by the gene PRDM1 located on chromosome...
disease." One serving, (1 cup or 240 mL) of soy milk, for instance, contains 6 or 7 grams of soy protein. An American Heart Association (AHA) review of a...
paraphyletic group, since any clade containing all fish, such as the Gnathostomata or (for bony fish) Osteichthyes, also contains the clade of tetrapods (four-limbed...
stimuli. They are present in the membranes of organisms from the three domains of life: bacteria, archaea, and eukarya. They are the sensors for a number...
be 4.9 grams/day (range 2.8-7.9 grams of resistant starch/day). A molecule of dietary fat typically consists of several fatty acids (containing long chains...
octubre de 2011. Castañeda, Roberto y otros (2010). Quesos de América del Sur. 1ª edición. Editorial Albatros. pp. 87–89. ISBN 978-950-24-1312-9. Angulo, Rafael...
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