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Glycogen phosphorylase information


Phosphorylase
The crystal structure of the rabbit muscle glycogen phosphorylase-AMP complex. AMP allosteric site (yellow), phosphorylated Ser14 (orange), glycogen binding site (blue), catalytic site (red).[1]
Identifiers
EC no.2.4.1.1
CAS no.9035-74-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

Glycogen phosphorylase is one of the phosphorylase enzymes (EC 2.4.1.1). Glycogen phosphorylase catalyzes the rate-limiting step in glycogenolysis in animals by releasing glucose-1-phosphate from the terminal alpha-1,4-glycosidic bond. Glycogen phosphorylase is also studied as a model protein regulated by both reversible phosphorylation and allosteric effects.

  1. ^ PDB: 3E3N

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Glycogen phosphorylase

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Glycogen phosphorylase is one of the phosphorylase enzymes (EC 2.4.1.1). Glycogen phosphorylase catalyzes the rate-limiting step in glycogenolysis in...

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Glycogenolysis

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phosphorolysis, by the enzyme glycogen phosphorylase. In the muscles, glycogenolysis begins due to the binding of cAMP to phosphorylase kinase, converting the...

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Glycogenesis

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activate phosphorylase kinase. This activates glycogen phosphorylase and inhibits glycogen synthase. Glycogenolysis Glycogen synthase Glycogen storage...

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Phosphorylase

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glucose-1-phosphate from a glucan such as glycogen, starch or maltodextrin. Phosphorylase is also a common name used for glycogen phosphorylase in honor of Earl W. Sutherland...

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Glycogen synthase

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been done on glycogen degradation through studying the structure and function of glycogen phosphorylase, the key regulatory enzyme of glycogen degradation...

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Myophosphorylase

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Myophosphorylase or glycogen phosphorylase, muscle associated (PYGM) is the muscle isoform of the enzyme glycogen phosphorylase and is encoded by the...

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Glycogen

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reduced, and glycogen synthesis stops. When it is needed for energy, glycogen is broken down and converted again to glucose. Glycogen phosphorylase is the primary...

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Phosphorylase kinase

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Phosphorylase kinase (PhK) is a serine/threonine-specific protein kinase which activates glycogen phosphorylase to release glucose-1-phosphate from glycogen...

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Glycogen storage disease type V

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continue to convert glycogen into glucose-1-phosphate even with high levels of glycogen-6-phosphate and ATP. (See Glycogen phosphorylase§Regulation). There...

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Glycogen storage disease

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it is another defect of glycogen storage and can cause similar problems. GSD type VIII (GSD 8): In the past, liver phosphorylase-b kinase deficiency was...

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Glycogen storage disease type VI

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Glycogen storage disease type VI (GSD VI) is a type of glycogen storage disease caused by a deficiency in liver glycogen phosphorylase or other components...

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Glycogen phosphorylase isoenzyme BB

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Glycogen phosphorylase isoenzyme BB (abbreviation: GPBB) is an isoenzyme of glycogen phosphorylase. This isoform of the enzyme exists in cardiac (heart)...

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Glucagon

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phosphorylates glycogen phosphorylase kinase. Phosphorylated glycogen phosphorylase kinase phosphorylates glycogen phosphorylase. Phosphorylated glycogen phosphorylase...

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Glycogen branching enzyme

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branching enzyme to provide glycogen breakdown enzymes, such as glycogen phosphorylase, with many terminal residues for rapid degradation. Branching also...

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Glycogen storage disease type IX

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Glycogen storage disease type IX is a hereditary deficiency of glycogen phosphorylase kinase B that affects the liver and skeletal muscle tissue. It is...

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Protein phosphatase 1

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complex. This dissociation activates glycogen synthase and converts phosphorylase a to phosphorylase b. Phosphorylase b does not bind PP1 allowing PP1 to...

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Phosphorolysis

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It is analogous to hydrolysis. An example of this is glycogen breakdown by glycogen phosphorylase, which catalyzes attack by inorganic phosphate on the...

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Inborn errors of carbohydrate metabolism

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their glycogen stores with the rest of the body. In addition to glycogen breakdown with the glycogen debranching enzyme and the glycogen phosphorylase enzyme...

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Louise Johnson

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studies on other enzymes. In 1972 she received some crystals of glycogen phosphorylase and this was the beginning of a major chapter in her research career...

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Glycogen debranching enzyme

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and glucosidase activities. Together with phosphorylases, the enzyme mobilize glucose reserves from glycogen deposits in the muscles and liver. This constitutes...

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Cardiac marker

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PMID 9323061. Lippi G, Mattiuzzi C, Comelli I, Cervellin G (2013). "Glycogen phosphorylase isoenzyme BB in the diagnosis of acute myocardial infarction: a...

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Glucosyltransferase

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that enable the transfer of glucose. Examples include: glycogen synthase glycogen phosphorylase They are categorized under EC number 2.4.1. edited by Ajit...

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Pyridoxal phosphate

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neurotransmitters, and heme. PLP is also found on glycogen phosphorylase in the liver, where it is used to break down glycogen in glycogenolysis when glucagon or epinephrine...

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Cyclic nucleotide

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activity of glycogen phosphorylase in dog liver. Glycogen phosphorylase catalyzes the first step in glycogenolysis, the process of breaking glycogen into its...

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Maltodextrin phosphorylase

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affinity for linear oligosaccharides than the related glycogen phosphorylase. Maltodextrin phosphorylase facilitates maltodextrin metabolism through phosphorolysis...

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PYGL

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Glycogen phosphorylase, liver form (PYGL), also known as human liver glycogen phosphorylase (HLGP), is an enzyme that in humans is encoded by the PYGL...

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Protein phosphorylation

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first phosphorylase enzyme was discovered by Carl and Gerty Cori in the late 1930s. Carl and Gerty Cori found two forms of glycogen phosphorylase which...

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