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Phosphorylase
The crystal structure of the rabbit muscle glycogen phosphorylase-AMP complex. AMP allosteric site (yellow), phosphorylated Ser14 (orange), glycogen binding site (blue), catalytic site (red).[1]
Identifiers
EC no.
2.4.1.1
CAS no.
9035-74-9
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BRENDA
BRENDA entry
ExPASy
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KEGG
KEGG entry
MetaCyc
metabolic pathway
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PDB structures
RCSB PDB PDBe PDBsum
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proteins
Glycogen phosphorylase is one of the phosphorylase enzymes (EC 2.4.1.1). Glycogen phosphorylase catalyzes the rate-limiting step in glycogenolysis in animals by releasing glucose-1-phosphate from the terminal alpha-1,4-glycosidic bond. Glycogen phosphorylase is also studied as a model protein regulated by both reversible phosphorylation and allosteric effects.
^PDB: 3E3N
and 27 Related for: Glycogen phosphorylase information
phosphorolysis, by the enzyme glycogenphosphorylase. In the muscles, glycogenolysis begins due to the binding of cAMP to phosphorylase kinase, converting the...
glucose-1-phosphate from a glucan such as glycogen, starch or maltodextrin. Phosphorylase is also a common name used for glycogenphosphorylase in honor of Earl W. Sutherland...
been done on glycogen degradation through studying the structure and function of glycogenphosphorylase, the key regulatory enzyme of glycogen degradation...
reduced, and glycogen synthesis stops. When it is needed for energy, glycogen is broken down and converted again to glucose. Glycogenphosphorylase is the primary...
Phosphorylase kinase (PhK) is a serine/threonine-specific protein kinase which activates glycogenphosphorylase to release glucose-1-phosphate from glycogen...
continue to convert glycogen into glucose-1-phosphate even with high levels of glycogen-6-phosphate and ATP. (See Glycogenphosphorylase§Regulation). There...
it is another defect of glycogen storage and can cause similar problems. GSD type VIII (GSD 8): In the past, liver phosphorylase-b kinase deficiency was...
Glycogen storage disease type VI (GSD VI) is a type of glycogen storage disease caused by a deficiency in liver glycogenphosphorylase or other components...
Glycogenphosphorylase isoenzyme BB (abbreviation: GPBB) is an isoenzyme of glycogenphosphorylase. This isoform of the enzyme exists in cardiac (heart)...
branching enzyme to provide glycogen breakdown enzymes, such as glycogenphosphorylase, with many terminal residues for rapid degradation. Branching also...
Glycogen storage disease type IX is a hereditary deficiency of glycogenphosphorylase kinase B that affects the liver and skeletal muscle tissue. It is...
complex. This dissociation activates glycogen synthase and converts phosphorylase a to phosphorylase b. Phosphorylase b does not bind PP1 allowing PP1 to...
It is analogous to hydrolysis. An example of this is glycogen breakdown by glycogenphosphorylase, which catalyzes attack by inorganic phosphate on the...
their glycogen stores with the rest of the body. In addition to glycogen breakdown with the glycogen debranching enzyme and the glycogenphosphorylase enzyme...
studies on other enzymes. In 1972 she received some crystals of glycogenphosphorylase and this was the beginning of a major chapter in her research career...
and glucosidase activities. Together with phosphorylases, the enzyme mobilize glucose reserves from glycogen deposits in the muscles and liver. This constitutes...
PMID 9323061. Lippi G, Mattiuzzi C, Comelli I, Cervellin G (2013). "Glycogenphosphorylase isoenzyme BB in the diagnosis of acute myocardial infarction: a...
that enable the transfer of glucose. Examples include: glycogen synthase glycogenphosphorylase They are categorized under EC number 2.4.1. edited by Ajit...
neurotransmitters, and heme. PLP is also found on glycogenphosphorylase in the liver, where it is used to break down glycogen in glycogenolysis when glucagon or epinephrine...
activity of glycogenphosphorylase in dog liver. Glycogenphosphorylase catalyzes the first step in glycogenolysis, the process of breaking glycogen into its...
affinity for linear oligosaccharides than the related glycogenphosphorylase. Maltodextrin phosphorylase facilitates maltodextrin metabolism through phosphorolysis...
Glycogenphosphorylase, liver form (PYGL), also known as human liver glycogenphosphorylase (HLGP), is an enzyme that in humans is encoded by the PYGL...
first phosphorylase enzyme was discovered by Carl and Gerty Cori in the late 1930s. Carl and Gerty Cori found two forms of glycogenphosphorylase which...