Phosphorolysis is the cleavage of a compound in which inorganic phosphate is the attacking group. It is analogous to hydrolysis.[1]
An example of this is glycogen breakdown by glycogen phosphorylase, which catalyzes attack by inorganic phosphate on the terminal glycosyl residue at the nonreducing end of a glycogen molecule. If the glycogen chain has n glucose units, the products of a single phosphorolytic event are one molecule of glucose 1-phosphate and a glycogen chain of n-1 remaining glucose units.
Action of Glycogen Phosphorylase on Glycogen
In addition, sometimes phosphorolysis is preferable to hydrolysis (like in the breakdown of glycogen or starch, as in the example above) because glucose 1-phosphate yields more ATP than does free glucose when subsequently catabolized to pyruvate.
Another example of phosphorolysis is seen in the conversion of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate in glycolysis. The mechanism involves phosphorolysis.
^Stryer, L. (1988) Biochemistry, 3rd ed., Freeman (p. 451)
mechanism involves phosphorolysis. Phosphorylase Stryer, L. (1988) Biochemistry, 3rd ed., Freeman (p. 451) Media related to Phosphorolysis at Wikimedia Commons...
branches are catabolized by the sequential removal of glucose monomers via phosphorolysis, by the enzyme glycogen phosphorylase. In the muscles, glycogenolysis...
charged nature of G6P. Glucose may alternatively be formed from the phosphorolysis or hydrolysis of intracellular starch or glycogen. In animals, an isozyme...
phosphorylase by the XapA gene. The enzyme's main functions are nucleoside phosphorolysis and the synthesis of nucleotides, making it a member of the purine nucleoside...
phosphorylase to produce monomers of glucose-1-phosphate: In vivo, phosphorolysis proceeds in the direction of glycogen breakdown because the ratio of...
to the enzyme, the active site of the enzyme is blocked; therefore phosphorolysis of G3P is unable to occur. High concentrations of tetrose diphosphate...
coli. This bacterial enzyme, often referred to as MalP, catalyzes the phosphorolysis of an α-1,4-glycosidic bond in maltodextrins, removing the non-reducing...
between C 1 of a glucose ring and the O that connects it to the next(phosphorolysis). One glucose unit is thus split off. Glycogen (with n glucose units)...
Press, New York, 1961, p. 229-236. FITTING C, DOUDOROFF M (1952). "Phosphorolysis of maltose by enzyme preparations from Neisseria meningitidis". J. Biol...
Embden–Meyerhof–Parnas pathway, the most common type of glycolysis, and phosphorolysis. Joseph Szydlowski, Polish-Israeli aircraft engine designer who founded...
170.8.3493-3498.1988. ISSN 0021-9193. Yamada EW (November 1961). "The phosphorolysis of nucleosides by rabbit bone marrow". The Journal of Biological Chemistry...
1MAS, 1R4F, 2C40, 2FF1, 2FF2, and 2MAS. HEPPEL LA, HILMOE RJ (1952). "[Phosphorolysis and hydrolysis of purine ribosides by enzymes from yeast.]". J. Biol...
activates the enzyme. As a glycogen phosphorylase, PYGL catalyzes the phosphorolysis of an α-1, 4-glycosidic bond in glycogen to yield glucose 1-phosphate...
tissue. Together with Władysław Baranowski, he discovered the process of phosphorolysis. Parnas also made a major contribution to the theoretical analysis of...
495-502. 10.1016/S0092-8674(04)00416-7. ROWEN JW, KORNBERG A (1951). "The phosphorolysis of nicotinamide riboside". J. Biol. Chem. 193 (2): 497–507. PMID 14907738...
doi:10.1016/S0021-9258(18)64123-7. PMID 13682989. Martin RG (1963). "The phosphorolysis of nucleosides by rabbit bone marrow: The nature of feedback inhibition...
Academic Press, New York, 1961, p. 237-255. HEPPEL LA, HILMOE RJ (1952). "[Phosphorolysis and hydrolysis of purine ribosides by enzymes from yeast.]". J. Biol...
found on chromosome 10. As a glycogen phosphorylase, GPBB catalyzes the phosphorolysis of glycogen to yield glucose 1-phosphate. This reaction serves as the...
Chemistry. 243 (11): 2899–904. PMID 5653182. Ayers WA (November 1959). "Phosphorolysis and synthesis of cellobiose by cell extracts from Ruminococcus flavefaciens"...
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