Ball-and-stick model based on the crystal structure.[1][2] Note that the phosphate and pyridine groups have reacted to form a zwitterion and the aldehyde group is hydrated.
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic reactions. The International Union of Biochemistry and Molecular Biology has catalogued more than 140 PLP-dependent activities, corresponding to ~4% of all classified activities.[5] The versatility of PLP arises from its ability to covalently bind the substrate, and then to act as an electrophilic catalyst, thereby stabilizing different types of carbanionic reaction intermediates.
^"CSD Entry: PLPHYD10". Cambridge Structural Database: Access Structures. Cambridge Crystallographic Data Centre. 1974. Archived from the original on 2023-11-04. Retrieved 2023-11-04.
^Fujiwara T (1973). "The Crystal and Molecular Structure of Vitamin B6 Derivatives. I. Pyridoxal Phosphate Hydrate and Pyridoxal Phosphate Methyl Hemiacetal". Bull. Chem. Soc. Jpn.46 (3): 863–871. doi:10.1246/bcsj.46.863.
^Kozlov ÉI, L'vova MS (1978). "Stability of water-soluble vitamins and coenzymes. Hydrolysis of pyridoxal-5-phosphate in acidic, neutral, and weakly alkaline solutions". Pharmaceutical Chemistry Journal. 11 (11): 1543–9. doi:10.1007/BF00778244. S2CID 1094223.
^Percudani R, Peracchi A (September 2003). "A genomic overview of pyridoxal-phosphate-dependent enzymes". EMBO Reports. 4 (9): 850–4. doi:10.1038/sj.embor.embor914. PMC 1326353. PMID 12949584.
and 22 Related for: Pyridoxal phosphate information
Pyridoxalphosphate (PLP, pyridoxal 5'-phosphate, P5P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic reactions. The International...
gained from the results of theoretical calculations. For example, pyridoxalphosphate, a form of vitamin B6, in aqueous solution is predicted to have an...
transsulfuration enzymes require vitamin B6 in its active form (pyridoxalphosphate or PLP). Three of these enzymes (cystathionine γ-synthase excluded)...
AspAT/ASAT/AAT or (serum) glutamic oxaloacetic transaminase (GOT, SGOT), is a pyridoxalphosphate (PLP)-dependent transaminase enzyme (EC 2.6.1.1) that was first described...
9 billion years ago, a forerunner of the Great Oxidation Event. Pyridoxalphosphate "CSD Entry: BIHKEI01". Cambridge Structural Database: Access Structures...
(5-HTP). Subsequently, 5-HTP undergoes decarboxylation, facilitated by pyridoxalphosphate and the enzyme 5-hydroxytryptophan decarboxylase, yielding serotonin...
L-glutamate ALT (and all aminotransferases) require the coenzyme pyridoxalphosphate, which is converted into pyridoxamine in the first phase of the reaction...
prosthetic groups are vitamin derivatives: thiamine pyrophosphate, pyridoxal-phosphate and biotin. Since prosthetic groups are often vitamins or made from...
reaction and Kabachnik–Fields reaction Imines are common in nature. The pyridoxalphosphate-dependent enzymes (PLP enzymes) catalyze myriad reactions involving...
PLP-dependent fold type I clade. They utilise the cofactor PLP (pyridoxalphosphate), which functions by stabilising carbanion intermediates. If it reacts...
which can be interconverted in biological systems. Its active form, pyridoxal 5′-phosphate, serves as a coenzyme in more than 140 enzyme reactions in amino...
pyridoxalphosphate (right), and the resulting product 4-hydroxyphenylpyruvate (center). Each side of the dimer protein includes pyridoxalphosphate (PLP)...
dehydratase or L-serine ammonia lyase (SDH) is in the β-family of pyridoxalphosphate-dependent (PLP) enzymes. SDH is found widely in nature, but its structure...
gamma-aminobutyric acid (GABA) and carbon dioxide (CO2). GAD uses pyridoxal-phosphate (PLP) as a cofactor. The reaction proceeds as follows: HOOC−CH2−CH2−CH(NH2)−COOH...
irreversible condensation of indole and serine to form tryptophan in a pyridoxalphosphate (PLP) dependent reaction. Each α active site is connected to a β...
L-amino acid decarboxylase (also known as DOPA decarboxylase), with pyridoxalphosphate as a cofactor. Dopamine is then converted into norepinephrine by...
Serine hydroxymethyltransferase (SHMT) is a pyridoxalphosphate (PLP) (Vitamin B6) dependent enzyme (EC 2.1.2.1) which plays an important role in cellular...
+ pyridoxal 5'-phosphate Thus, the two substrates of this enzyme are ATP and pyridoxal, whereas its two products are ADP and pyridoxal 5'-phosphate. This...
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