Glycerol kinase, encoded by the gene GK, is a phosphotransferase enzyme involved in triglycerides and glycerophospholipids synthesis.
Glycerol kinase catalyzes the transfer of a phosphate from ATP to glycerol thus forming glycerol 3-phosphate:
ATP + glycerol <=> ADP + sn-glycerol 3-phosphate
Adipocytes lack glycerol kinase so they cannot metabolize the glycerol produced during triacyl glycerol degradation. This glycerol is instead shuttled to the liver via the blood where it is:
Phosphorylated by glycerol kinase to glycerol 3-phosphate.
Converted from glycerol 3-phosphate to dihydroxyacetone phosphate (DHAP) via glycerol 3-phosphate dehydrogenase. DHAP can participate in glycolysis or gluconeogenesis.
from ATP to glycerol thus forming glycerol 3-phosphate: ATP + glycerol <=> ADP + sn-glycerol 3-phosphate Adipocytes lack glycerolkinase so they cannot...
glyceraldehyde 3-phosphate in the following steps: GlycerolGlycerolkinase ATP ADP Glycerol-3-phosphate Glycerol-3-phosphate dehydrogenase NAD+ NADH NAD+ NADH...
Glycerolkinase deficiency (GKD) is an X-linked recessive enzyme defect that is heterozygous in nature. Three clinically distinct forms of this deficiency...
into glycerol 3-phosphate by the action of glycerolkinase which hydrolyzes one molecule of ATP per glycerol molecule which is phosphorylated. Glycerol 3-phosphate...
known as glycerolkinase deficiency (GKD), is a genetic disorder where the enzyme glycerolkinase is deficient resulting in a build-up of glycerol in the...
gaisha, a type of Japanese business organization GK, the gene encoding Glycerolkinase, a phosphotransferase enzyme Guntur Kaaram, an 2024 Indian Telugu-language...
pathway which synthesizes glycerol 3-phosphate (used to form triglycerides) from precursors other than glucose. Usually, glycerol 3-phosphate is generated...
it is converted to glycerol 3-phosphate by the enzyme glycerol kinase. Hepatic glycerol 3-phosphate is converted mostly into dihydroxyacetonephosphate...
glycerol moiety and an unsaturated fatty acid at the C-2 position. Diacylglycerol can be phosphorylated to phosphatidic acid by diacylglycerol kinase...
Allgrove syndrome). DAX-1 mutations may cluster in a syndrome with glycerolkinase deficiency with a number of other symptoms when DAX-1 is deleted together...
2006.03.003. PMID 16626678. Park, Y.; Kim, Y. (2014). "A specific glycerolkinase induces rapid cold hardening of the diamondback moth, Plutella xylostella"...
enzymology, an alkylglycerol kinase (EC 2.7.1.93) is an enzyme that catalyzes the chemical reaction ATP + 1-O-alkyl-sn-glycerol ⇌ {\displaystyle \rightleftharpoons...
phosphate from glycerol is a reaction regulated by the synthesis rate of glycerolkinase and by feedback inhibition by fructose-1,6-bisphosphate. The study...
into glycerol-3-phosphate, which can be used to form triglycerides. Conversely, triglycerides can be broken down into fatty acids and glycerol; the latter...
acyl-sn-glycerol 3-phosphate The two substrates of this enzyme are ATP and acylglycerol, whereas its two products are ADP and acyl-sn-glycerol 3-phosphate...
dephosphorylated and this allows it to inhibit adenylate cyclase, glycerolkinase, lactose permease, and maltose permease. Thus, in addition to being...
results in a condition called adrenal hypoplasia congenita with complex glycerolkinase deficiency. In addition to the signs and symptoms of adrenal hypoplasia...
nearly 25% of the volume of a typical cell. In glycolysis, glucose and glycerol are metabolized to pyruvate. Glycolysis generates two equivalents of ATP...
by DAG kinase (DAGK). By the acylation of lysophosphatidic acid by lysoPA-acyltransferase (LPAAT); this is the most common pathway. The glycerol 3-phosphate...
Henry (1978). "Subunit dissociation in the allosteric regulation of glycerolkinase from Escherichia coli. 2. Physical evidence". Biochemistry. 17 (24):...
Hayashi SI, Lin EC (March 1967). "Purification and properties of glycerolkinase from Escherichia coli". The Journal of Biological Chemistry. 242 (5):...
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