The glucokinase regulatory protein (GKRP) also known as glucokinase (hexokinase 4) regulator (GCKR) is a protein produced in hepatocytes (liver cells). GKRP binds and moves glucokinase (GK), thereby controlling both activity and intracellular location[1][2] of this key enzyme of glucose metabolism.[3]
GKRP is a 68 kD protein of 626 amino acids. It is coded for by a 19 exon gene, GCKR, on the short arm of chromosome 2 (2p23). GKRP was discovered by Emile van Schaftingen and reported in 1989[4]
^Van Schaftingen E (September 1994). "Short-term regulation of glucokinase". Diabetologia. 37 (Suppl 2): S43-7. doi:10.1007/bf00400825. PMID 7821739.
^de la Iglesia N, Veiga-da-Cunha M, Van Schaftingen E, Guinovart JJ, Ferrer JC (August 1999). "Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase". FEBS Letters. 456 (2): 332–8. doi:10.1016/S0014-5793(99)00971-0. PMID 10456334. S2CID 11923216.
^Iynedjian PB (January 2009). "Molecular physiology of mammalian glucokinase". Cellular and Molecular Life Sciences. 66 (1): 27–42. doi:10.1007/s00018-008-8322-9. PMC 2780631. PMID 18726182.
^Van Schaftingen E (January 1989). "A protein from rat liver confers to glucokinase the property of being antagonistically regulated by fructose 6-phosphate and fructose 1-phosphate". European Journal of Biochemistry. 179 (1): 179–84. doi:10.1111/j.1432-1033.1989.tb14538.x. PMID 2917560.
and 27 Related for: Glucokinase regulatory protein information
The glucokinaseregulatoryprotein (GKRP) also known as glucokinase (hexokinase 4) regulator (GCKR) is a protein produced in hepatocytes (liver cells)...
(August 2014). "A patent review of glucokinase activators and disruptors of the glucokinase--glucokinaseregulatoryprotein interaction: 2011-2014". Expert...
the SIS (sugar isomerase) family of proteins. The gene product is a regulatoryprotein that inhibits glucokinase in liver and pancreatic islet cells by...
glucokinase is also used in the liver, which has a much lower affinity for glucose (Km in the vicinity of normal glycemia), and differs in regulatory...
Little is known about the regulatory characteristics of this isoenzyme. Mammalian hexokinase IV, also referred to as glucokinase, differs from other hexokinases...
is converted to F1P in the liver. This negates the action of F6P on glucokinase, which ultimately favors the forward reaction. The capacity of liver...
(2012). "Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinaseregulatoryprotein (GCKR) polymorphisms and lifestyle factors with the...
genetic regulation of follistatin secretion from the liver is via Glucokinaseregulatoryprotein (GCKR) identified by large GWAS studies. It is also investigated...
(1999-10-26). "Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related...
levels. Glucose is converted into glucose 6-phosphate by the action of glucokinase or hexokinase with conversion of ATP to ADP. Glucose-6-phosphate is converted...
occurs: Glucose gets converted to Glucose-6-Phosphate (G6P) through Glucokinase, and G6P is subsequently oxidized to form ATP. This process inhibits...
first enzyme in the glycolysis pathway, has a specialized form called glucokinase expressed in the liver and pancreas that has a lower affinity for glucose...
may help identify and aid such women at risk. Hexokinase HK1 HK2 HK3 Glucokinase GRCh38: Ensembl release 89: ENSG00000156510 – Ensembl, May 2017 GRCm38:...
glucose is low); it triggers phosphorylation of enzymes and regulatoryproteins by Protein Kinase A (a cyclic AMP regulated kinase) resulting in inhibition...
and fat cells. Once within cells, glucose is rapidly phosphorylated by glucokinase in the liver and hexokinase in other tissues to form glucose-6-phosphate...
enters the β-cell is phosphorylated to glucose-6-phosphate (G-6-P) by glucokinase (hexokinase IV) which is not inhibited by G-6-P in the way that the hexokinases...
example of an isozyme is glucokinase, a variant of hexokinase which is not inhibited by glucose 6-phosphate. Its different regulatory features and lower affinity...
seven protein subunits. The catalytic mTOR subunit, DEP domain containing mTOR-interacting protein (DEPTOR), mammalian lethal with sec-13 protein 8 (mLST8...
81-84. Neet, K. E.; Tippett, P. S.; and Keenan, R. P. (1986) Regulatory Properties of Glucokinase, Regulation and Metabolism. Wiley, London. Tippett, P. S...
PFKFB2 gene. The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that...
GTP-binding protein of the RAS superfamily. Ran GTPase is a master regulatory switch, which among other functions, controls the shuttling of proteins between...
carbohydrate phosphorylation response to insulin positive regulation of glucokinase activity fructose 2,6-bisphosphate metabolic process animal organ regeneration...
Global Information