Genetic ablation occurs when a gene is deemed “null” through the homologous genetic recombination of a gene. It is utilized in the selective suppression of a specific cell line or cell type. This genetic engineering technique does not limit growth suppression to just the activity of an individual gene.[1] Specific cell ablation enables the examination of the in vivo activity of cells. An example of this method in action can be seen through the production of a knockout mouse. This is accomplished through the administration of one or more transgenes into a fertilized mouse oocyte’s pronucleus. Afterwards, it is reimplanted into a host mother, who then births a transgenic mouse. The transgenic mouse carries one copy of the transgene3 out of several hundred. From these mice, a homozygous colony can be created through breeding.[2]
^Crommelin, D.J.A.; Sindelar, R.D. (1997). Pharmaceutical Biotechnology: Fundamentals and Applications. Philadelphia, PA: Taylor and Francis.
^Seidman, J.G. (2009). "Manipulating the Mouse Genome". Current Protocols in Molecular Biology. 85. doi:10.1002/0471142727.mb2300s85. S2CID 221604198.
Geneticablation occurs when a gene is deemed “null” through the homologous genetic recombination of a gene. It is utilized in the selective suppression...
of target specificity. The geneticablation techniques described could prove useful in battling cancer. Electro-ablation, is a process that removes material...
Cell ablation (from Latin Cellula "small chamber" and Ablatio "removal"). Also known as tissue ablation, cell ablation is a biotechnological tool for...
This is a list of genetic hybrids which is limited to well documented cases of animals of differing species able to create hybrid offspring which may or...
In computer science and operations research, a genetic algorithm (GA) is a metaheuristic inspired by the process of natural selection that belongs to...
Krause corpuscle afferent terminals evoked penile erection, while geneticablation of Krause corpuscles impaired intromission and ejaculation of males...
remodeling. Researchers at Universities of Angers and Ulster evidenced that geneticablation of the GIP receptor in mice resulted in profound alterations of bone...
Genetics is the study of genes, genetic variation, and heredity in organisms. It is an important branch in biology because heredity is vital to organisms'...
pathway is causative from Parkinson disease (PD) in humans. Toxic and/or geneticablation of SNpc neurons produces experimental parkinsonism in mice and primates...
A genetic predisposition is a genetic characteristic which influences the possible phenotypic development of an individual organism within a species or...
Genetic diversity is the total number of genetic characteristics in the genetic makeup of a species. It ranges widely, from the number of species to differences...
sexual orientation), national origin, age (40 or older), disability or genetic information. Similarly in the UK, the Equality Act 2010 was put in place...
The genetic code is the set of rules used by living cells to translate information encoded within genetic material (DNA or RNA sequences of nucleotide...
Genetic counseling is the process of investigating individuals and families affected by or at risk of genetic disorders to help them understand and adapt...
barrier (BBB) and has an essential role in BBB formation and function. Geneticablation of MFSD2A results in leaky BBB and increases central nervous system...
role in axon regeneration. However, recently, it was found through geneticablation studies that astrocytes are actually required for regeneration to occur...
Sanchez R., Rodriguez-Manzaneque M. T., Bosl M. R., et al. (2008). Geneticablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral...
Genetically modified foods (GM foods), also known as genetically engineered foods (GE foods), or bioengineered foods are foods produced from organisms...
Genetic recombination (also known as genetic reshuffling) is the exchange of genetic material between different organisms which leads to production of...
The genetic history of Sardinia consists of the study of the gene pool of the Sardinian people with two main objectives. The first is purely cultural...
benefit from the less-invasive septal ablation procedure. When performed properly, an alcohol septal ablation induces a controlled heart attack, in which...
phosphotyrosine residues of the activated insulin receptor kinase. In mice, geneticablation of PTPN1 results in enhanced insulin sensitivity. Several other tyrosine...
focusing on the European genetic origin in Ashkenazi maternal lineages, contrasting with the predominantly Middle Eastern genetic origin in paternal lineages...
Genetic studies of Jews are part of the population genetics discipline and are used to analyze the ancestry of Jewish populations, complementing research...
Miosge N, Baranowsky A, Mokkapati S, et al. (August 2005). "Compound geneticablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality...
genetics, transformation is the genetic alteration of a cell resulting from the direct uptake and incorporation of exogenous genetic material from its surroundings...
A genetically modified organism (GMO) is any organism whose genetic material has been altered using genetic engineering techniques. The exact definition...
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