Nidogens, formerly known as entactins, are a family of sulfated monomeric glycoproteins located in the basal lamina[1] of parahoxozoans.[2] Two nidogens have been identified in humans: nidogen-1 (NID1) and nidogen-2 (NID2).[3] Remarkably, vertebrates are still capable of stabilizing basement membrane in the absence of either identified nidogen.[4] In contrast, those lacking both nidogen-1 and nidogen-2 typically die prematurely during embryonic development as a result of defects existing in the heart and lungs.[5] Nidogen have been shown to play a crucial role during organogenesis in late embryonic development, particularly in cardiac and lung development.[6] Insufficient levels of nidogen in mice causes poorly developed organs such as the lungs and heart, which ultimately ensues to an early death.[7] Due to nidogen being necessary in the formation of basement membranes, serving as a linker protein, and those basement proteins being shown to be necessary during tissue growth, nidogen is crucial for embryonic development.[8] From an evolutionary perspective, nidogens are highly conserved across vertebrates and invertebrates, retaining their ability to bind laminin.[9]
In nematodes, nidogen-1 is necessary for axon guidance, but not for basement membrane assembly.[10]
^Hortsch M, Umemori H (2009). The Sticky Synapse: Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance. New York, NY: Springer. p. 66. ISBN 9780387927084.
^Nielsen C (July 2019). "Early animal evolution: a morphologist's view". Royal Society Open Science. 6 (7): 190638. Bibcode:2019RSOS....690638N. doi:10.1098/rsos.190638. PMC 6689584. PMID 31417759.
^Miosge N, Holzhausen S, Zelent C, Sprysch P, Herken R (2001). "Nidogen-1 and nidogen-2 are found in basement membranes during human embryonic development". The Histochemical Journal. 33 (9–10): 523–530. doi:10.1023/A:1014995523521. PMID 12005023. S2CID 818451.
^Lössl P, Kölbel K, Tänzler D, Nannemann D, Ihling CH, Keller MV, et al. (2014-11-11). Kobe B (ed.). "Analysis of nidogen-1/laminin γ1 interaction by cross-linking, mass spectrometry, and computational modeling reveals multiple binding modes". PLOS ONE. 9 (11): e112886. Bibcode:2014PLoSO...9k2886L. doi:10.1371/journal.pone.0112886. PMC 4227867. PMID 25387007.
^Fox MA, Ho MS, Smyth N, Sanes JR (September 2008). "A synaptic nidogen: developmental regulation and role of nidogen-2 at the neuromuscular junction". Neural Development. 3 (1): 24. doi:10.1186/1749-8104-3-24. PMC 2567315. PMID 18817539.
^Bader BL, Smyth N, Nedbal S, Miosge N, Baranowsky A, Mokkapati S, et al. (August 2005). "Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice". Molecular and Cellular Biology. 25 (15): 6846–6856. doi:10.1128/MCB.25.15.6846-6856.2005. PMC 1190363. PMID 16024816.
^Lakshmanan HH, Melrose AR, Sepp AI, Mitrugno A, Ngo AT, Khader A, et al. (April 2021). "The basement membrane protein nidogen-1 supports platelet adhesion and activation". Platelets. 32 (3): 424–428. doi:10.1080/09537104.2020.1745170. PMC 8559984. PMID 32233694.
^Dziadek M (September 1995). "Role of laminin-nidogen complexes in basement membrane formation during embryonic development". Experientia. 51 (9–10): 901–913. doi:10.1007/BF01921740. PMID 7556571.
^Mayer U, Kohfeldt E, Timpl R (October 1998). "Structural and genetic analysis of laminin-nidogen interaction". Annals of the New York Academy of Sciences. 857 (1): 130–142. Bibcode:1998NYASA.857..130M. doi:10.1111/j.1749-6632.1998.tb10113.x. PMID 9917838. S2CID 36725654.
^Kim S, Wadsworth WG (April 2000). "Positioning of longitudinal nerves in C. elegans by nidogen". Science. 288 (5463): 150–154. Bibcode:2000Sci...288..150K. doi:10.1126/science.288.5463.150. PMID 10753123.
Nidogens, formerly known as entactins, are a family of sulfated monomeric glycoproteins located in the basal lamina of parahoxozoans. Two nidogens have...
domain has been shown to be the only one that binds with a high affinity to nidogen. The binding-sites are located on the surface within the loops C1-C3 and...
with integrin a1b1, fibronectin and components of basement membranes like nidogen and perlecan. COL13A1 – XIV FACIT collagen, also known as undulin COL14A1...
layer composed of collagen (mainly type I collagen fibrils), laminin, nidogen, perlecan and other HSPGs that protects the corneal stroma. When discussed...
chief components of Matrigel are structural proteins such as laminin, nidogen, collagen and heparan sulfate proteoglycans which present cultured cells...
neurotoxin is internalised at the neuromuscular junction through binding the nidogen proteins and is retrogradely transported towards the soma in signaling...
Look up nid in Wiktionary, the free dictionary. Nid or NID may refer to: Nidogen-1, an extracellular protein Neuronal intestinal dysplasia, a condition...
cell adhesion. Laminins bind other ECM components such as collagens and nidogens. There are many cell types that contribute to the development of the various...
cleaves components of the basal lamina such as collagen type IV, laminin 5, nidogen (entactin) and other ECM proteins such as tenascin, aggrecan and fibronectin...
SNED1 (Sushi, Nidogen, and EGF-like Domains) is an extracellular matrix (ECM) protein expressed at low levels in a wide range of tissues. The gene encoding...
to a number of extracellular matrix constituents including fibronectin, nidogen-1, and the proteoglycan, versican. Fibulin-1 is also a blood protein capable...
The major components of Cultrex BME include laminin, collagen, entactin/nidogen, and heparin sulfate proteoglycans. These components are found in the basement...
and endothelial basement membrane also contains laminin, perlecan and nidogen. Hyaluronic acid, a pure glycosaminoglycan component, is found in high...
Perlecan expression and thus basement membrane maturation is dependent on nidogen crosslinking of collagen IV and laminin γ1 chain in this system. This effect...
"Activity of MMP-19 inhibits capillary-like formation due to processing of nidogen-1". Cell Mol Life Sci. 61 (14): 1826–33. doi:10.1007/s00018-004-4105-0...
Göhring W; Mann K; Timpl R (August 2001). "Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan"...