Embryonic inner cell mass tissue that forms the yolk sac and, later, chorion
Hypoblast
Human embryo on day 9. Hypoblast (brown) is beneath the epiblast (pink)
Details
Days
8
Precursor
Inner cell mass
Gives rise to
Endoderm
Identifiers
Latin
hypoblastus
TE
E6.0.1.1.3.0.4
Anatomical terminology
[edit on Wikidata]
In amniote embryology, the hypoblast is one of two distinct layers arising from the inner cell mass in the mammalian blastocyst,[1][2] or from the blastodisc in reptiles and birds. The hypoblast gives rise to the yolk sac, which in turn gives rise to the chorion.[3]
The hypoblast is a layer of cells in fish and amniote embryos. The hypoblast helps determine the embryo's body axes, and its migration determines the cell movements that accompany the formation of the primitive streak, and helps to orient the embryo, and create bilateral symmetry.
The other layer of the inner cell mass, the epiblast, differentiates into the three primary germ layers, ectoderm, mesoderm, and endoderm.
^Palmer, N.; Kaldis, P. (2016-01-01), DePamphilis, Melvin L. (ed.), "Chapter One - Regulation of the Embryonic Cell Cycle During Mammalian Preimplantation Development", Current Topics in Developmental Biology, Mammalian Preimplantation Development, 120, Academic Press: 1–53, doi:10.1016/bs.ctdb.2016.05.001, PMID 27475848, retrieved 2020-10-16
^Keefe, David L.; Winkler, Nurit (2007-01-01), Sokol, Andrew I.; Sokol, Eric R. (eds.), "Chapter 1 - Embryology", General Gynecology, Philadelphia: Mosby, pp. 1–20, doi:10.1016/b978-032303247-6.10001-2, ISBN 978-0-323-03247-6, retrieved 2020-10-16
^Hafez, S. (2017-01-01), Huckle, William R. (ed.), "Chapter One - Comparative Placental Anatomy: Divergent Structures Serving a Common Purpose", Progress in Molecular Biology and Translational Science, Molecular Biology of Placental Development and Disease, 145, Academic Press: 1–28, doi:10.1016/bs.pmbts.2016.12.001, PMID 28110748, retrieved 2020-10-16
In amniote embryology, the hypoblast is one of two distinct layers arising from the inner cell mass in the mammalian blastocyst, or from the blastodisc...
visceral endoderm (hypoblast). The hypoblast also plays an important role in the regulation of streak formation. Removal of the hypoblast in the chick results...
developed from the epiblast. The hypoblast is pushed down and forms the yolk sac (exocoelomic cavity) lining. Some hypoblast cells migrate along the inner...
blastocyst, or from the blastula in reptiles and birds, the other layer is the hypoblast. It drives the embryo proper through its differentiation into the three...
trophoblast. During formation of the primary yolk sac, some of the migrating hypoblast cells differentiate into mesenchymal cells that fill the space between...
sac is a membranous sac attached to an embryo, formed by cells of the hypoblast layer of the bilaminar embryonic disc. This is alternatively called the...
developed from the epiblast. The hypoblast is pushed down and forms the yolk sac (exocoelomic cavity) lining. Some hypoblast cells migrate along the inner...
the epiblast. The cells of the layers move between the epiblast and the hypoblast, and begin to spread laterally and cranially. The cells of the epiblast...
primitive endoderm (or hypoblast) fate, while the remaining cells adopt a primitive ectoderm (or epiblast) fate. The hypoblast contributes to extraembryonic...
The hypoblast forms the roof of the exocoelomic cavity and is continuous with the thin exocoelomic membrane. This membrane along with hypoblast forms...
undergoes implantation. The inner cell mass initially has two layers: the hypoblast and epiblast. At the end of the second week, a primitive streak appears...
imbedded in the uterine decidua Signaling pathway to inducing endoderm Hypoblast of primitive endoderm Ectoderm Germ layer Histogenesis Mesoderm Organogenesis...
and they become the mesoderm and endoderm. As the hypoblast cells move inward future mesoderm (hypoblast cells) start to move vegetally and proliferate but...
towards the side of the embryonic epiblast, and "ventral" more towards the hypoblast side, regardless of the organism's posture and physical orientation. Other...
discoidal meroblastic cleavage. The blastoderm develops into the epiblast and hypoblast and it is between these layers that the blastocoel will form. The shape...
sac is a membranous sac attached to an embryo, formed by cells of the hypoblast layer of the bilaminar embryonic disc. This is alternatively called the...
ectoderm and endoderm. The two layers are also sometimes referred to as the hypoblast and epiblast. Sponges do not go through the gastrula stage. Gastrulation...
germ cells use another path. PGCs come from the epiblast and move to the hypoblast to form the germinal crescent (anterior extraembryonic structure). The...
more generally, the generation of new tissues at any stage of life. hypoblast in vitro fertilization (IVF) ingression inner cell mass invagination involution...
an external epiblast layer (the primitive ectoderm), and an internal hypoblast layer (primitive endoderm). This gives the early bilaminar disc. In the...
endodermal cells migrate anteriorly and eventually displace the hypoblast cells, causing the hypoblast cells to be confined to a region in the anterior portion...
function leads to a range of developmental defects. FGFs secreted by hypoblasts during avian gastrulation play a role in stimulating a Wnt signaling pathway...
that eventually form the pharynx. Gastrulation ends when epiboly of the hypoblasts closes the blastopore. Under environmental conditions favourable for reproduction...
specification of the inner cell mass results in the formation of the hypoblast and epiblast. Later on in postimplantation development, the anterior-posterior...
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