The gal operon is a prokaryotic operon, which encodes enzymes necessary for galactose metabolism.[1] Repression of gene expression for this operon works via binding of repressor molecules to two operators. These repressors dimerize, creating a loop in the DNA. The loop as well as hindrance from the external operator prevent RNA polymerase from binding to the promoter, and thus prevent transcription.[2] Additionally, since the metabolism of galactose in the cell is involved in both anabolic and catabolic pathways, a novel regulatory system using two promoters for differential repression has been identified and characterized within the context of the gal operon.
^Weickert, M. J.; Adhya, S. (October 1993). "The galactose regulon of Escherichia coli". Molecular Microbiology. 10 (2): 245–251. doi:10.1111/j.1365-2958.1993.tb01950.x. ISSN 0950-382X. PMID 7934815. S2CID 6872903.
^Roy, Siddhartha; Semsey, Szabolcs; Liu, Mofang; Gussin, Gary N.; Adhya, Sankar (2004-11-26). "GalR represses galP1 by inhibiting the rate-determining open complex formation through RNA polymerase contact: a GalR negative control mutant". Journal of Molecular Biology. 344 (3): 609–618. doi:10.1016/j.jmb.2004.09.070. ISSN 0022-2836. PMID 15533432.
The galoperon is a prokaryotic operon, which encodes enzymes necessary for galactose metabolism. Repression of gene expression for this operon works...
The lactose operon (lac operon) is an operon required for the transport and metabolism of lactose in E. coli and many other enteric bacteria. Although...
example, specific binding of HU at the galoperon facilitates the formation of a DNA loop that keeps the galoperon repressed in the absence of the inducer...
discoordinate expression of the galoperon (i.e., the individual genes in the operon are not similarly expressed) by binding to the galK Shine-Dalgarno region...
Galactose (/ɡəˈlæktoʊs/, galacto- + -ose, "milk sugar"), sometimes abbreviated Gal, is a monosaccharide sugar that is about as sweet as glucose, and about 65%...
L; Adhya, S (1983). "A control element within a structural gene: the galoperon of Escherichia coli". Cell. 32 (3): 783–788. doi:10.1016/0092-8674(83)90064-8...
products, and the removal of lactose. B-galactosidase forms the basis of lac z operon in bacteria which can be used to control gene expression. B-galactosidase...
system is widely considered to be the identification in 1961 of the lac operon, discovered by François Jacob and Jacques Monod, in which some enzymes involved...
The sequence of the bacterial att site is called attB, between the gal and bio operons, and consists of the parts B-O-B', whereas the complementary sequence...
salt agar is differential for mannitol fermentation. X-gal plates are differential for lac operon mutants. Transport media should fulfill these criteria:...
base-specifically to the major groove of the operator region of the lac operon, with base contacts also made by residues of symmetry-related alpha helices...
many of these are operons is unclear. C. elegans and other nematodes are among the few eukaryotes currently known to have operons; these include trypanosomes...
feed-forward loop which accelerates the activation of galactose utilization operongalETK, potentially facilitating the metabolic transition to galactose when...
PMID 8844169. Pál C, Hurst LD (2004-06-01). "Evidence against the selfish operon theory". Trends in Genetics. 20 (6): 232–234. doi:10.1016/j.tig.2004.04...
host's immune system. mgtC leader RNA from bacteria virulence gene (mgtCBR operon) decreases flagellin production during infection by directly base pairing...
two recombinases and is a model example of site specific inversion. The operon consists of the promoter region fim S, the main constituent fim A, its gene...
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