Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Gabaculine is a naturally occurring neurotoxin first isolated from the bacteria Streptomyces toyacaensis,[1] which acts as a potent and irreversible GABA transaminase inhibitor,[2][3] and also a GABA reuptake inhibitor.[4][5] Gabaculine is also known as 3-amino-2,3-dihydrobenzoic acid hydrochloride [6] and 5-amino cyclohexa-1,3 dienyl carboxylic acid.[7] Gabaculine increased GABA levels in the brain and had an effect on convulsivity in mice.[7]
^Kobayashi K, Miyazawa S, Endo A (April 1977). "Isolation and inhibitory activity of gabaculine, a new potent inhibitor of gamma-aminobutyrate aminotransferase produced by a Streptomyces". FEBS Letters. 76 (2): 207–10. doi:10.1016/0014-5793(77)80153-1. PMID 862902.
^Rando RR (October 1977). "Mechanism of the irreversible inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase by the neurotoxin gabaculine". Biochemistry. 16 (21): 4604–10. doi:10.1021/bi00640a012. PMID 410442.
^Irifune M, Katayama S, Takarada T, et al. (December 2007). "MK-801 enhances gabaculine-induced loss of the righting reflex in mice, but not immobility". Can J Anaesth. 54 (12): 998–1005. doi:10.1007/BF03016634. PMID 18056209.
^Allan RD, Johnston GAR, Twitchin B. Effects of Gabaculine on uptake, binding and metabolism of GABA. Neuroscience Letters. 1977;4:51-54.
^Høg S, Greenwood JR, Madsen KB, Larsson OM, Frølund B, Schousboe A, Krogsgaard-Larsen P, Clausen RP (2006). "Structure-activity relationships of selective GABA uptake inhibitors". Current Topics in Medicinal Chemistry. 6 (17): 1861–82. doi:10.2174/156802606778249801. PMID 17017962. Archived from the original on 2013-04-14.
^Santa Cruz Biotechnology, Inc. "Gabaculine Material Safety Data Sheet". Retrieved 5 December 2014.
^ abMutsui, Yoshiki; Deguchi, Takehiko (1977). "Effects of gabaculine, a new potent inhibitor of gamma-aminobutyrate transaminase, on brain gamma-aminobutyrate content and convulsions in mice". Life Sciences. 20 (7): 1291–1296. doi:10.1016/0024-3205(77)90505-7. PMID 850479.
Gabaculine is a naturally occurring neurotoxin first isolated from the bacteria Streptomyces toyacaensis, which acts as a potent and irreversible GABA...
its lack of specificity has prompted further designs of ALR inhibitors. Gabaculine and Vigabatrin inhibit GABA aminotransferase Canaline and 5-fluoromethylornithine...
mass: 139.0633 u) may refer to: Ammonium benzoate Deferiprone (Ferriprox) Gabaculine This set index page lists chemical structure articles associated with...
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