RNA polymerase II cis-regulatory region sequence-specific DNA binding
Cellular component
nucleus
intracellular anatomical structure
cytoplasm
nucleoplasm
protein-containing complex
Biological process
negative regulation of cell population proliferation
negative regulation of NF-kappaB transcription factor activity
B cell homeostasis
regulation of isotype switching to IgG isotypes
myeloid cell homeostasis
negative regulation of inflammatory response
positive regulation of interleukin-4 production
regulation of immunoglobulin production
regulation of transcription by RNA polymerase II
regulation of T cell anergy
negative regulation of interleukin-6 production
tolerance induction to self antigen
regulation of transcription, DNA-templated
negative regulation of DNA-binding transcription factor activity
positive regulation of T cell tolerance induction
negative regulation of immune response
negative regulation of interferon-gamma production
tolerance induction
regulatory T cell differentiation
positive regulation of transcription, DNA-templated
negative regulation of interleukin-2 production
positive regulation of histone acetylation
negative regulation of interleukin-5 production
negative regulation of chronic inflammatory response
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
positive regulation of transcription by RNA polymerase II
negative regulation of activated T cell proliferation
positive regulation of gene expression
negative regulation of interleukin-4 production
negative regulation of interleukin-10 production
negative regulation of tumor necrosis factor production
T cell homeostasis
negative regulation of CREB transcription factor activity
negative regulation of T-helper 17 cell differentiation
T cell activation
positive regulation of immature T cell proliferation in thymus
positive regulation of regulatory T cell differentiation
negative regulation of transcription by RNA polymerase II
positive regulation of peripheral T cell tolerance induction
positive regulation of transforming growth factor beta1 production
negative regulation of transcription, DNA-templated
negative regulation of lymphocyte proliferation
negative regulation of histone acetylation
negative regulation of interleukin-17 production
response to virus
negative regulation of histone deacetylation
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
negative regulation of T cell proliferation
chromatin remodeling
cytokine production
negative regulation of T cell cytokine production
negative regulation of isotype switching to IgE isotypes
T cell receptor signaling pathway
positive regulation of T cell anergy
transcription, DNA-templated
T cell mediated immunity
negative regulation of gene expression
anatomical structure morphogenesis
regulation of Wnt signaling pathway
regulation of regulatory T cell differentiation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
50943
20371
Ensembl
ENSG00000049768
ENSMUSG00000039521
UniProt
Q9BZS1
Q99JB6
RefSeq (mRNA)
NM_001114377 NM_014009
NM_001199347 NM_001199348 NM_054039
RefSeq (protein)
NP_001107849 NP_054728
NP_001186276 NP_001186277 NP_473380
Location (UCSC)
Chr X: 49.25 – 49.27 Mb
Chr X: 7.44 – 7.46 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
FOXP3 (forkhead box P3), also known as scurfin, is a protein involved in immune system responses.[5] A member of the FOX protein family, FOXP3 appears to function as a master regulator of the regulatory pathway in the development and function of regulatory T cells.[6][7][8] Regulatory T cells generally turn the immune response down. In cancer, an excess of regulatory T cell activity can prevent the immune system from destroying cancer cells. In autoimmune disease, a deficiency of regulatory T cell activity can allow other autoimmune cells to attack the body's own tissues.[9][10]
While the precise control mechanism has not yet been established, FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription. In regulatory T cell model systems, the FOXP3 transcription factor occupies the promoters for genes involved in regulatory T-cell function, and may inhibit transcription of key genes following stimulation of T cell receptors.[11]
^ abcGRCh38: Ensembl release 89: ENSG00000049768 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000039521 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F (January 2001). "Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse". Nature Genetics. 27 (1): 68–73. doi:10.1038/83784. PMID 11138001. S2CID 13389419.
^Hori S, Nomura T, Sakaguchi S (February 2003). "Control of regulatory T cell development by the transcription factor Foxp3". Science. 299 (5609): 1057–61. Bibcode:2003Sci...299.1057H. doi:10.1126/science.1079490. PMID 12522256. S2CID 9697928.
^Fontenot JD, Gavin MA, Rudensky AY (April 2003). "Foxp3 programs the development and function of CD4+CD25+ regulatory T cells". Nature Immunology. 4 (4): 330–6. doi:10.1038/ni904. PMID 12612578. S2CID 3343021.
^Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY (March 2005). "Regulatory T cell lineage specification by the forkhead transcription factor foxp3". Immunity. 22 (3): 329–41. doi:10.1016/j.immuni.2005.01.016. PMID 15780990.
^Josefowicz SZ, Lu LF, Rudensky AY (January 2012). "Regulatory T cells: mechanisms of differentiation and function". Annual Review of Immunology. 30 (January): 531–64. doi:10.1146/annurev.immunol.25.022106.141623. PMC 6066374. PMID 22224781.
^Zhang L, Zhao Y (June 2007). "The regulation of Foxp3 expression in regulatory CD4(+)CD25(+)T cells: multiple pathways on the road". Journal of Cellular Physiology. 211 (3): 590–7. doi:10.1002/jcp.21001. PMID 17311282.
^Marson A, Kretschmer K, Frampton GM, Jacobsen ES, Polansky JK, MacIsaac KD, Levine SS, Fraenkel E, von Boehmer H, Young RA (February 2007). "Foxp3 occupancy and regulation of key target genes during T-cell stimulation". Nature. 445 (7130): 931–5. Bibcode:2007Natur.445..931M. doi:10.1038/nature05478. PMC 3008159. PMID 17237765.
FOXP3 (forkhead box P3), also known as scurfin, is a protein involved in immune system responses. A member of the FOX protein family, FOXP3 appears to...
proliferation of effector T cells. Treg cells express the biomarkers CD4, FOXP3, and CD25 and are thought to be derived from the same lineage as naïve CD4+...
IPEX is caused by mutations in the gene FOXP3, which encodes transcription factor forkhead box P3 (FOXP3). FOXP3 is widely considered to be the master regulator...
tumor. Forkhead box protein 3 (Foxp3) as a transcription factor is an essential molecular marker of Treg cells. Foxp3 polymorphism (rs3761548) might be...
X-linked syndrome (IPEX syndrome) is X-linked recessive due to mutation of the FOXP3 gene on the X chromosome. Most patients develop diabetes and diarrhea and...
thymus. Two major classes of CD4+ Treg cells have been described—FOXP3+ Treg cells and FOXP3− Treg cells. Regulatory T cells can develop either during normal...
factor beta (TGF-β). Th3 have been described both in mice and human as CD4+FOXP3− regulatory T cells. Th3 cells were first described in research focusing...
of developing asthma. Studies have shown a positive correlation between Foxp3 methylation and children's exposure to NO2, CO, and PM2.5. Furthermore,...
acetylation in the promoter and conserved non-coding sequence regions of the FOXP3 locus, thus regulating the T cells, resulting in the reduction of the inflammatory...
known for his research on regulatory T cells and the transcription factor Foxp3. Rudensky received his Candidate of Sciences degree in 1986 from the Gabrichevsky...
(hyperplastic, hypersecretory gastropathy), and intestinal metaplasia. In addition, Foxp3 polymorphism (rs3761548) might contribute to gastric cancer development...
forkhead box protein 3 (FOXP3) as a transcription factor is an essential molecular marker of regulatory T (Treg) cells. FOXP3 polymorphism (rs3761548)...
tolerance. Tregs, characterized by the expression of the transcription factor Foxp3, exert immunosuppressive effects by inhibiting the activation and function...
expression of HLA‐DR2 and HLA‐DR15 (mean age of two groups: 34 and 21 years), FOXP3, CD95, and CCR4; lower expression of CD45RA (mean age: 45 years); and expression...
Forkhead box protein 3 (Foxp3) as a transcription factor is an essential molecular marker of regulatory T (Treg) cells. Foxp3 polymorphism (rs3761548)...
implementation of self tolerance, which is mediated by CD4+CD25+Foxp3 nTreg cells. Foxp3 Treg development is supported by mTECs during negative selection...
currently in phase II clinical trials. Neurovax is designed to stimulate FOXP3+ regulatory T-cells that can then suppress the autoreactive T-cells in some...
mofetil-based immunosuppression changes the frequency and phenotype of CD4+FOXP3+ regulatory T cells". Transplantation. 87 (7): 1062–1068. doi:10.1097/tp...
Then allograft tolerance is mostly observed. TGF-β induces expression of Foxp3 gene in the absence of proinflammatory cytokines and thus differentiation...
prevents allergy, but accelerates tumor growth by promoting immunoregulatory Foxp3+ cells: Mouse model for passive respiratory exposure". Scientific Reports...
macrophages, dendritic cells). IL2RA has been used as a marker to identify CD4+FoxP3+ regulatory T cells in mice, and it has been found that a large proportion...
CD45+, CD3+ T helper cell CD45+, CD3+, CD4+ T regulatory cell CD4, CD25, FOXP3 (a transcription factor) Cytotoxic T cell CD45+, CD3+, CD8+ B lymphocyte...
immunity-related genes AIRE (causing autoimmune polyglandular syndrome), FoxP3 (causing IPEX syndrome), or STAT3 include type 1 diabetes in their effects...
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