positive regulation of cell adhesion mediated by integrin
mesoderm development
regulation of organ growth
metanephros development
cell population proliferation
positive regulation of transcription by RNA polymerase II
negative regulation of apoptotic process involved in outflow tract morphogenesis
transcription by RNA polymerase II
cell differentiation
regulation of transcription by RNA polymerase II
anatomical structure morphogenesis
negative regulation of cold-induced thermogenesis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2303
14234
Ensembl
ENSG00000176692
ENSMUSG00000046714
UniProt
Q99958
Q61850
RefSeq (mRNA)
NM_005251
NM_013519
RefSeq (protein)
NP_005242
NP_038547
Location (UCSC)
Chr 16: 86.57 – 86.57 Mb
Chr 8: 121.84 – 121.85 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Forkhead box protein C2 (FOXC2) also known as forkhead-related protein FKHL14 (FKHL14), transcription factor FKH-14, or mesenchyme fork head protein 1 (MFH1) is a protein that in humans is encoded by the FOXC2 gene.[5][6] FOXC2 is a member of the fork head box (FOX) family of transcription factors.
^ abcGRCh38: Ensembl release 89: ENSG00000176692 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000046714 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kaestner KH, Bleckmann SC, Monaghan AP, Schlöndorff J, Mincheva A, Lichter P, Schütz G (June 1996). "Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development". Development. 122 (6): 1751–8. doi:10.1242/dev.122.6.1751. PMID 8674414.
^Miura N, Iida K, Kakinuma H, Yang XL, Sugiyama T (May 1997). "Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures". Genomics. 41 (3): 489–92. doi:10.1006/geno.1997.4695. PMID 9169153.
Forkhead box protein C2 (FOXC2) also known as forkhead-related protein FKHL14 (FKHL14), transcription factor FKH-14, or mesenchyme fork head protein 1...
been linked to a mutations in the ‘forkhead’ family transcription factor (FOXC2) gene located on the long arm of chromosome 16 (16q24.3). It is the most...
member B FBRS: Probably fibrosin-1 long transcript protein FOXC2-AS1: encoding protein FOXC2 antisense RNA 1 GLG1: Golgi apparatus protein 1 HBAP1: Hemoglobin...
Ed. Ng MY, Andrew T, Spector TD, Jeffery S (March 2005). "Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected...
promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation". Science Signaling. 6 (257): ra2...
promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation". Science Signaling. 6 (257): ra2...
this gene have been associated with TOF, accounting for 2.4% of all cases. FOXC2 is another gene involved in embryonic development of the cardiac system...
regulation of embryonic and ocular development. FOXC1 and its close relative, FOXC2 are both critical components in the development of the heart and blood vessels...
Hartwell K, Richardson AL, Weinberg RA (June 2007). "Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like...
necrotic and decays. Using a patented cocktail of plasmids (Etv2, Fli1, Foxc2, or EFF), these factors were delivered to the tissue above the surgery site...
Kanady, J. D; Munger, S. J; Witte, M. H; Simon, A. M (2015). "Combining Foxc2 and Connexin37 deletions in mice leads to severe defects in lymphatic vascular...
factor contributes to controlling the expression of two genes, PROX1 and FOXC2, which are required for the proper development of the lymphatic system,...
characteristics. GSC, along with other transcription factors like Twist, FOXC2, and Snail, induce epithelial to mesenchymal transitions by regulating the...
Tsutomu; Relaix, Frédéric; Buckingham, Margaret E. (December 2009). "Pax3:Foxc2 Reciprocal Repression in the Somite Modulates Muscular versus Vascular Cell...