Chain molecule which folds in predictable ways while in solution
Crystal structure of a foldamer reported in [1].Dynamic view of an alpha-beta foldamer
In chemistry, a foldamer is a discrete chain molecule (oligomer) that folds into a conformationally ordered state in solution. They are artificial molecules that mimic the ability of proteins, nucleic acids, and polysaccharides to fold into well-defined conformations, such as α-helices and β-sheets. The structure of a foldamer is stabilized by noncovalent interactions between nonadjacent monomers.[2][3] Foldamers are studied with the main goal of designing large molecules with predictable structures. The study of foldamers is related to the themes of molecular self-assembly, molecular recognition, and host–guest chemistry.
^Lehn, Jean-Marie; et al. (2003). "Helicity-Encoded Molecular Strands: Efficient Access by the Hydrazone Route and Structural Features". Helv. Chim. Acta. 86 (5): 1598–1624. doi:10.1002/hlca.200390137.
^Cite error: The named reference Foldamer was invoked but never defined (see the help page).
^Hill, D. J.; Mio, M. J.; Prince, R. B.; Hughes, T. S.; Moore, J. S. (2001). "A field guide to foldamers". Chem. Rev. 101 (12): 3893–4012. doi:10.1021/cr990120t. PMID 11740924.
In chemistry, a foldamer is a discrete chain molecule (oligomer) that folds into a conformationally ordered state in solution. They are artificial molecules...
atropisomerism, organolithium chemistry, remote stereochemical effects and dynamic foldamer chemistry. He is one of the authors of the organic chemistry textbook -...
particular peptide binding motif. Examples involve D-peptide and peptidic foldamers such as beta-peptides. These structural mimetics include molecules that...
p-xylylenediammonium bound within a cucurbituril Intramolecular self-assembly of a foldamer 3D interpenetrated network in the crystal structure of silsesquioxane The...
Biological dark matter Body plan Directed evolution Expanded genetic code Foldamer Hachimoji DNA Hypothetical types of biochemistry Life definitions Nucleic...
Glycine, or Ornithine as the basic structure for protein-like polymers (foldamers) would lead to parallel biological worlds. They would have morphologically...
molecules that nature did not synthesize—miniature proteins, β-peptide foldamers, polyproline hairpins, and proto-fluorescent ligands—and the use of these...
heterogeneity which doesn’t allow for the formation of homogeneous peptoid foldamers. Nonetheless, scientists were able to find trans-inducer N-Aryl side chains...
the market. Brilacidin, a non-peptide chemical mimic, is an aryl amide foldamer designed to replicate the amphiphilic properties of antimicrobial peptides...
"Supramolecular Helical Systems: Helical Assemblies of Small Molecules, Foldamers, and Polymers with Chiral Amplification and Their Functions". Chemical...
Vladimir Kubyshkin, the new-to-nature hydrophobic polyproline-II helix foldamer was designed. Along with Budisa's previous work on bioexpression using...
nanoparticle surfaces). Specific interests include self-replicating molecules, foldamers, catalysis, molecular recognition of biomolecules and self-synthesizing...
and non-native peptides: using Affimers to recognise α-helix mimicking foldamers" (PDF). Chemical Communications. 53 (19): 2834–2837. doi:10.1039/c6cc09395g...
24 The Marine Sponge Polytheonamide B (pTB) Family 1.D.25 The Arylamine Foldamer (AAF) Family 1.D.26 The Dihydrodehydrodiconiferyl alcohol 9'-O-β-D-glucoside...
Christian; Hecht, Stefan (13 March 2006). "Prototype of a Photoswitchable Foldamer". Angewandte Chemie International Edition. 45 (12): 1878–1881. doi:10.1002/anie...
aren't easily accessible by other means. These include smart materials, foldamers, self-assembling molecules with interlocking architectures and new soft...
Martin V, Legrand B, Vezenkov LL. Turning peptide sequences into ribbon foldamers by a straightforward multicyclization reaction. Angewandte Chemie 2015;54:1-6...
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