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Foldamer information


Crystal structure of a foldamer reported in [1].
Dynamic view of an alpha-beta foldamer

In chemistry, a foldamer is a discrete chain molecule (oligomer) that folds into a conformationally ordered state in solution. They are artificial molecules that mimic the ability of proteins, nucleic acids, and polysaccharides to fold into well-defined conformations, such as α-helices and β-sheets. The structure of a foldamer is stabilized by noncovalent interactions between nonadjacent monomers.[2][3] Foldamers are studied with the main goal of designing large molecules with predictable structures. The study of foldamers is related to the themes of molecular self-assembly, molecular recognition, and host–guest chemistry.

  1. ^ Lehn, Jean-Marie; et al. (2003). "Helicity-Encoded Molecular Strands: Efficient Access by the Hydrazone Route and Structural Features". Helv. Chim. Acta. 86 (5): 1598–1624. doi:10.1002/hlca.200390137.
  2. ^ Cite error: The named reference Foldamer was invoked but never defined (see the help page).
  3. ^ Hill, D. J.; Mio, M. J.; Prince, R. B.; Hughes, T. S.; Moore, J. S. (2001). "A field guide to foldamers". Chem. Rev. 101 (12): 3893–4012. doi:10.1021/cr990120t. PMID 11740924.

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Cabalteja CC, Mihalko DS, Horne WS (November 2018). "Heterogeneous-backbone foldamer mimics of a computationally designed, disulfide-rich miniprotein". ChemBioChem...

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molecules that nature did not synthesize—miniature proteins, β-peptide foldamers, polyproline hairpins, and proto-fluorescent ligands—and the use of these...

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heterogeneity which doesn’t allow for the formation of homogeneous peptoid foldamers. Nonetheless, scientists were able to find trans-inducer N-Aryl side chains...

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and non-native peptides: using Affimers to recognise α-helix mimicking foldamers" (PDF). Chemical Communications. 53 (19): 2834–2837. doi:10.1039/c6cc09395g...

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Transporter Classification Database

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24 The Marine Sponge Polytheonamide B (pTB) Family 1.D.25 The Arylamine Foldamer (AAF) Family 1.D.26 The Dihydrodehydrodiconiferyl alcohol 9'-O-β-D-glucoside...

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aren't easily accessible by other means. These include smart materials, foldamers, self-assembling molecules with interlocking architectures and new soft...

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