Brilacidin (formerly PMX-30063[2]), an investigational new drug, is a polymer-based antibiotic currently in human clinical trials, and represents a new class of antibiotics called host defense protein mimetics, or HDP-mimetics, which are non-peptide synthetic small molecules modeled after host defense peptides (HDPs).[3][4][5] HDPs, also called antimicrobial peptides, some of which are defensins, are part of the innate immune response and are common to most higher forms of life.[6][7] As brilacidin is modeled after a defensin, it is also called a defensin mimetic.[citation needed]
Brilacidin is an antibiotic that works by disrupting bacterial cell membranes, mimicking defensins that play a role in innate immunity.[8][9] Several mimics of antimicrobial peptides, both peptides and non-peptides, have been studied, but none have overcome difficulties to reach the market.
^ ab"Statement on a nonproprietary name adopted by the USAN council" (PDF). American Medical Association. 25 July 2012. {{cite journal}}: Cite journal requires |journal= (help)
^"Fact Sheet" (PDF). PolyMedix. Archived from the original (PDF) on 4 March 2016. Retrieved 23 April 2015.
^Palermo EF (2011). "Antimicrobial Polymers: peptide-mimetic design and mechanism of action" (PDF). University of Michigan Library.
^Palermo EF (2011). "The convergence of peptide and polymer science toward novel antibiotics" (PDF). University of Michigan Library. 158pages
^Sgolastra F. "Design and synthesis of biomimetic compounds with pharmacological activity" (PDF). Universita' Politecnica Delle Marche.
^Kuroda K, Caputo GA (2013). "Antimicrobial polymers as synthetic mimics of host-defense peptides". Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. 5 (1): 49–66. doi:10.1002/wnan.1199. hdl:2027.42/94848. PMID 23076870.
^"Designing mimics of membrane active proteins" (PDF). Accounts of Chemical Research
^Butler MS, Cooper MA (June 2011). "Antibiotics in the clinical pipeline in 2011". The Journal of Antibiotics. 64 (6): 413–25. doi:10.1038/ja.2011.44. PMID 21587262.
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