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The terminology used in the field of Dynamic Combinatorial Chemistry (DCC) and Constitutional Dynamic Chemistry (CDC).[1][2]
Dynamic combinatorial chemistry (DCC); also known as constitutional dynamic chemistry (CDC) is a method to the generation of new molecules formed by reversible reaction of simple building blocks under thermodynamic control.[3][4] The library[further explanation needed] of these reversibly interconverting building blocks is called a dynamic combinatorial library (DCL).[5][6] All constituents in a DCL are in equilibrium, and their distribution is determined by their thermodynamic stability within the DCL. The interconversion of these building blocks may involve covalent or non-covalent interactions. When a DCL is exposed to an external influence (such as proteins or nucleic acids), the equilibrium shifts and those components that interact with the external influence are stabilised and amplified, allowing more of the active compound to be formed.
^Lehn, Jean-Marie (2007). "From supramolecular chemistry towards constitutional dynamic chemistry and adaptive chemistry". Chem. Soc. Rev. 36 (2): 151–160. doi:10.1039/B616752G. ISSN 0306-0012. PMID 17264919.
^Lehn, Jean-Marie (2011). "Constitutional dynamic chemistry: Bridge from supramolecular chemistry to adaptive chemistry". In Barboiu, Mihail (ed.). Constitutional Dynamic Chemistry. Topics in Current Chemistry. Vol. 322. Springer Berlin Heidelberg. pp. 1–32. doi:10.1007/128_2011_256. ISBN 978-3-642-28343-7. PMID 22169958.
^Schaufelberger, F.; Timmer, B. J. J.; Ramström, O. Principles of Dynamic Covalent Chemistry. In Dynamic Covalent Chemistry: Principles, Reactions, and Applications; Zhang, W.; Jin, Y., Eds.; John Wiley & Sons: Chichester, 2018; Chapter 1, pp 1–30.
^Corbett, P. T.; Leclaire, J.; Vial, L.; West, K. R.; Wietor, J.-L.; Sanders, J. K. M.; Otto, S. (Sep 2006). "Dynamic combinatorial chemistry". Chem. Rev. 106 (9): 3652–3711. doi:10.1021/cr020452p. PMID 16967917.
^Komáromy, D.; Nowak, P.; Otto, S. Dynamic Combinatorial Libraries. In Dynamic Covalent Chemistry: Principles, Reactions, and Applications; Zhang, W.; Jin, Y., Eds.; John Wiley & Sons: Chichester, 2018; Chapter 2, pp 31–119.
^Lehn, J.-M.; Ramström, O. Generation and screening of a dynamic combinatorial library. PCT. Int. Appl. WO 20010164605, 2001.
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