Flumetasone pivalate information

Flumetasone pivalate
Clinical data
Other names	Flumetasone 21-pivalate
Drug class	Corticosteroid; Glucocorticoid
Identifiers
	IUPAC name (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-17-(2-(2,2-dimethylpropionyl)oxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one;
CAS Number	2002-29-1;
PubChem CID	443980;
UNII	0DV09X6F21;
CompTox Dashboard (EPA)	DTXSID7049005 ;
ECHA InfoCard	100.016.275
Chemical and physical data
Formula	C27H36F2O6
Molar mass	494.576 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COC(=O)C(C)(C)C)O)C)O)F)C)F;
	InChI InChI=1S/C27H36F2O6/c1-14-9-16-17-11-19(28)18-10-15(30)7-8-24(18,5)26(17,29)20(31)12-25(16,6)27(14,34)21(32)13-35-22(33)23(2,3)4/h7-8,10,14,16-17,19-20,31,34H,9,11-13H2,1-6H3/t14-,16+,17+,19+,20+,24+,25+,26+,27+/m1/s1; Key:JWRMHDSINXPDHB-OJAGFMMFSA-N;

Flumetasone pivalate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. It is the 21-acetate ester of flumetasone.^[1]^[2]^[3]

^ A Sayed R, Mohamed AR, Hassan WS, Elmasry MS (June 2021). "Comparative study of novel green UV-spectrophotometric platforms for simultaneous rapid analysis of flumethasone pivalate and clioquinol in their combined formulation". Drug Development and Industrial Pharmacy. 47 (6): 867–877. doi:10.1080/03639045.2021.1908341. PMID 34224277. S2CID 235746754.
^ "Flumethasone pivalate (Locorten). Anti-inflammatory, antipruritic". Clinical Pharmacology and Therapeutics. 11 (6): 927–929. 1970-11-06. doi:10.1002/cpt1970116927. PMID 5481576. S2CID 126851. Archived from the original on 2022-08-20. Retrieved 2022-08-20.
^ Hopkała H, Przyborowski L (June 1988). "Determination of drugs containing fluorine with ion-selective electrode. Part 1: Synthetic glucocorticosteroids". Die Pharmazie. 43 (6): 422–423. PMID 3212030.

[1] A Sayed R, Mohamed AR, Hassan WS, Elmasry MS (June 2021). "Comparative study of novel green UV-spectrophotometric platforms for simultaneous rapid analysis of flumethasone pivalate and clioquinol in their combined formulation". Drug Development and Industrial Pharmacy. 47 (6): 867–877. doi:10.1080/03639045.2021.1908341. PMID 34224277. S2CID 235746754.

[2] "Flumethasone pivalate (Locorten). Anti-inflammatory, antipruritic". Clinical Pharmacology and Therapeutics. 11 (6): 927–929. 1970-11-06. doi:10.1002/cpt1970116927. PMID 5481576. S2CID 126851. Archived from the original on 2022-08-20. Retrieved 2022-08-20.

[3] Hopkała H, Przyborowski L (June 1988). "Determination of drugs containing fluorine with ion-selective electrode. Part 1: Synthetic glucocorticosteroids". Die Pharmazie. 43 (6): 422–423. PMID 3212030.

Flumetasone pivalate information

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List of corticosteroid esters

Triamcinolone acetonide

Fluticasone

Betamethasone dipropionate

Fludrocortisone

Prednisone

Corticosteroid

Clobetasol

Fluocinonide

Deflazacort

Fluticasone furoate

Clobetasol propionate

Miconazole

Hydrocortisone

Betamethasone

Fluocinolone acetonide

Fluticasone propionate

Triamcinolone

Betamethasone valerate

Segesterone acetate

Cortisol

Hydrocortisone valerate

Tetrahydrogestrinone

Desoximetasone

Budesonide

Clocortolone

Ketoconazole