Fluocinonide information

Fluocinonide
Clinical data
Trade names	Fluonex, Lidex, others
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a601054
Routes of; administration	Topical
ATC code	C05AA11 (WHO) D07AC08 (WHO), QC05AA11 (WHO), QD07AC08 (WHO);
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: WARNINGRx-only;
Pharmacokinetic data
Metabolism	Liver
Identifiers
	IUPAC name 6α,9-difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone,21-acetate;
CAS Number	356-12-7 ;
PubChem CID	9642;
IUPHAR/BPS	7078;
DrugBank	DB01047 ;
ChemSpider	9265 ;
UNII	2W4A77YPAN;
KEGG	D00325 ;
ChEMBL	ChEMBL1501 ;
CompTox Dashboard (EPA)	DTXSID8045307 ;
ECHA InfoCard	100.005.998
Chemical and physical data
Formula	C26H32F2O7
Molar mass	494.532 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC(=O)[C@]45OC(O[C@@H]5C[C@@H]2[C@@]4(C[C@H](O)[C@]3(F)[C@]/1(/C=C\C(=O)\C=C\1[C@@H](F)C[C@@H]23)C)C)(C)C)C;
	InChI InChI=1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1 ; Key:WJOHZNCJWYWUJD-IUGZLZTKSA-N ;
	(verify)

Fluocinonide is a potent glucocorticoid used topically as an anti-inflammatory agent for the treatment of skin disorders such as eczema and seborrhoeic dermatitis.^[3] It relieves itching, redness, dryness, crusting, scaling, inflammation, and discomfort.^[3]

A common potential adverse effect is skin atrophy (thinning of the skin).^[4]

In 2021, it was the 249th most commonly prescribed medication in the United States, with more than 1 million prescriptions.^[5]^[6]

^ "Fluocinonide Topical". MedlinePlus Drug Information. U.S. National Library of Medicine.
^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^ ^a ^b "Fluocinonide Topical: MedlinePlus Drug Information". medlineplus.gov. Retrieved 16 November 2022.
^ Jablonska S, Groniowska M, Dabroswki J (February 1979). "Comparative evaluation of skin atrophy in man induced by topical corticoids". The British Journal of Dermatology. 100 (2): 193–206. doi:10.1111/j.1365-2133.1979.tb05561.x. PMID 154921. S2CID 30656827.
^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^ "Fluocinonide - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.

[1] "Fluocinonide Topical". MedlinePlus Drug Information. U.S. National Library of Medicine.

[FDA-AllBoxedWarnings-2] "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.

[:1-3] "Fluocinonide Topical: MedlinePlus Drug Information". medlineplus.gov. Retrieved 16 November 2022.

[:0-4] Jablonska S, Groniowska M, Dabroswki J (February 1979). "Comparative evaluation of skin atrophy in man induced by topical corticoids". The British Journal of Dermatology. 100 (2): 193–206. doi:10.1111/j.1365-2133.1979.tb05561.x. PMID 154921. S2CID 30656827.

[5] "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.

[6] "Fluocinonide - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.

Fluocinonide information

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Fluocinonide

Topical steroid

Discoid lupus erythematosus

Pregnane

Corticosteroid

ATC code D07

Alopecia areata

Glucocorticoid

Fluticasone propionate

Triamcinolone

Dexamethasone

Hydrocortisone

Clobetasol propionate

Triamcinolone acetonide

Prednisone

Tazarotene

Psoriasis

Clobetasol

Cortisol

Steroid

Mometasone

Progesterone

Steroid dementia syndrome

Aphthous stomatitis

Cortisone

Fluticasone

Teva Pharmaceuticals

Methylprednisolone

Deflazacort

Clinical data

Trade names	Fluonex, Lidex, others^[1]
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a601054
Routes of administration	Topical
ATC code	C05AA11 (WHO) D07AC08 (WHO), QC05AA11 (WHO), QD07AC08 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only) US: WARNING^[2]Rx-only
Pharmacokinetic data
Metabolism	Liver
Identifiers
IUPAC name 6α,9-difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone,21-acetate
CAS Number	356-12-7^Y
PubChem CID	9642
IUPHAR/BPS	7078
DrugBank	DB01047^Y
ChemSpider	9265^Y
UNII	2W4A77YPAN
KEGG	D00325^Y
ChEMBL	ChEMBL1501^Y
CompTox Dashboard (EPA)	DTXSID8045307
ECHA InfoCard	100.005.998
Chemical and physical data
Formula	C₂₆H₃₂F₂O₇
Molar mass	494.532 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(OCC(=O)[C@]45OC(O[C@@H]5C[C@@H]2[C@@]4(C[C@H](O)[C@]3(F)[C@]/1(/C=C\C(=O)\C=C\1[C@@H](F)C[C@@H]23)C)C)(C)C)C
InChI InChI=1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1^Y Key:WJOHZNCJWYWUJD-IUGZLZTKSA-N^Y
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