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Fluticasone furoate information


Fluticasone furoate
Clinical data
Trade namesFlonase, Sensimist, Veramyst, Avamys, Ellipta, others
AHFS/Drugs.comMonograph
License data
  • US DailyMed: Fluticasone furoate
Pregnancy
category
  • AU: B3[1]
Routes of
administration
Intranasal, by mouth
ATC code
  • R01AD12 (WHO) R03BA09 (WHO) R03AK10 (WHO) R03AL08 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)[2][3]
  • CA: ℞-only[4]
  • UK: POM (Prescription only)[5]
  • US: OTC[6]/ Rx-only[7]
  • EU: Rx-only[8]
Pharmacokinetic data
Bioavailability0.51% (Intranasal)
Protein binding91%
MetabolismIntranasal
Liver (CYP3A4-mediated)
Elimination half-life15 hours
ExcretionKidney
Identifiers
IUPAC name
  • (6α,11β,16α,17α)-6,9-difluoro-17-{[(fluoro-methyl)thio]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl 2-furancarboxylate
CAS Number
  • 397864-44-7
PubChem CID
  • 9854489
DrugBank
  • DB08906
ChemSpider
  • 8030195
UNII
  • JS86977WNV
KEGG
  • D06315
ChEBI
  • CHEBI:74899
ChEMBL
  • ChEMBL1676
CompTox Dashboard (EPA)
  • DTXSID401024827 DTXSID60228586, DTXSID401024827 Edit this at Wikidata
ECHA InfoCard100.158.130 Edit this at Wikidata
Chemical and physical data
FormulaC27H29F3O6S
Molar mass538.58 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)SCF)OC(=O)C5=CC=CO5)C)O)F)C)F
InChI
  • InChI=1S/C27H29F3O6S/c1-14-9-16-17-11-19(29)18-10-15(31)6-7-24(18,2)26(17,30)21(32)12-25(16,3)27(14,23(34)37-13-28)36-22(33)20-5-4-8-35-20/h4-8,10,14,16-17,19,21,32H,9,11-13H2,1-3H3/t14-,16+,17+,19+,21+,24+,25+,26+,27+/m1/s1
  • Key:XTULMSXFIHGYFS-VLSRWLAYSA-N

Fluticasone furoate, sold under the brand name Flonase Sensimist among others, is a corticosteroid for the treatment of non-allergic and allergic rhinitis administered by a nasal spray.[9] It is also available as an inhaled corticosteroid to help prevent and control symptoms of asthma. It is derived from cortisol.[10] Unlike fluticasone propionate, which is only approved for children four years and older, fluticasone furoate is approved in children as young as two years of age when used for allergies.[6][11]

It was approved for medical use in the United States in April 2007, and in the European Union in November 2008.[12][8] In 2021, fluticasone was the 23rd most commonly prescribed medication in the United States, with more than 25 million prescriptions.[13][14]

  1. ^ "Fluticasone Use During Pregnancy". Drugs.com. 9 January 2019. Archived from the original on 26 March 2019. Retrieved 4 February 2020.
  2. ^ "AVAMYS fluticasone furoate nasal spray bottle (131443)". Department of Health and Ages Care. Archived from the original on 2 March 2023. Retrieved 1 April 2023.
  3. ^ "Arnuity Elliptafluticasone furoate 50 microgram powder for inhalation dry powder inhaler (300141)". Department of Health and Ages Care. Archived from the original on 2 March 2023. Retrieved 1 April 2023.
  4. ^ "Product monograph brand safety updates". Health Canada. 7 July 2016. Retrieved 3 April 2024.
  5. ^ "Avamys 27.5 micrograms/spray, nasal spray suspension - Summary of Product Characteristics (SmPC)". (emc). 4 June 2021. Archived from the original on 8 June 2023. Retrieved 18 June 2023.
  6. ^ a b Cite error: The named reference Flonase Sensimist FDA label was invoked but never defined (see the help page).
  7. ^ Cite error: The named reference Arnuity Ellipta FDA label was invoked but never defined (see the help page).
  8. ^ a b "Avamys EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 5 June 2020. Retrieved 5 June 2020.
  9. ^ Bruni FM, De Luca G, Venturoli V, Boner AL (2009). "Intranasal corticosteroids and adrenal suppression". Neuroimmunomodulation. 16 (5): 353–362. doi:10.1159/000216193. PMID 19571596. S2CID 35006163. Archived from the original on 18 May 2019. Retrieved 18 May 2019.
  10. ^ Kaliner MA (2011). Rhinitis, An Issue of Immunology and Allergy Clinics - E-Book. Elsevier Health Sciences. ISBN 9781455709328.
  11. ^ "Veramyst- fluticasone furoate spray, metered". DailyMed. 1 March 2010. Archived from the original on 5 February 2020. Retrieved 4 February 2020.
  12. ^ "Drug Approval Package: Veramyst (fluticasone furoate) NDA #022051". U.S. Food and Drug Administration (FDA). 30 August 2010. Archived from the original on 5 February 2020. Retrieved 4 February 2020.
  13. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  14. ^ "Fluticasone - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.

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Fluticasone furoate

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Fluticasone furoate, sold under the brand name Flonase Sensimist among others, is a corticosteroid for the treatment of non-allergic and allergic rhinitis...

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Fluticasone

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is also sold over the counter. Fluticasone furoate Fluticasone furoate/vilanterol Fluticasone propionate Fluticasone/salmeterol Elks J (14 November 2014)...

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Fluticasone propionate

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Fluticasone propionate, sold under the brand names Flovent and Flonase among others, is a steroid medication. When inhaled it is used for the long term...

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Mometasone

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of urinary cortisol suppression after inhalation of fluticasone propionate and mometasone furoate". British Journal of Clinical Pharmacology. 64 (5):...

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Vilanterol

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(ultra-LABA), which was approved in May 2013 in combination with fluticasone furoate for sale as Breo Ellipta by GlaxoSmithKline for the treatment of...

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List of GSK plc products

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vilanterol) Arnuity Ellipta (fluticasone furoate) Augmentin (amoxicillin/clavulanate potassium) Avamys (fluticasone furoate) Avodart (dutasteride) Bactroban...

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Corticosteroid

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Flunisolide Fluticasone furoate Fluticasone propionate Triamcinolone acetonide Beclomethasone dipropionate Budesonide Mometasone furoate Ciclesonide There...

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Decongestant

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Dexamethasone Flunisolide (Nasarel) Fluticasone Fluticasone furoate (Veramyst) Fluticasone propionate (Flonase) Azelastine/fluticasone (Dymista) – also an antihistamine...

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Umeclidinium bromide

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bromide/vilanterol) and also as a triple-therapy combination as fluticasone furoate/umeclidinium bromide/vilanterol. It is on the World Health Organization's...

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Rhinitis medicamentosa

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rhinitis medicamentosa especially with use of intranasal steroid like fluticasone furoate. The treatment of RM involves withdrawal of the offending nasal spray...

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Beclometasone

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candidiasis associated with inhaled corticosteroid use: comparison of fluticasone and beclomethasone". Annals of Allergy, Asthma & Immunology. 90 (6):...

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ATC code R03

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Formoterol and mometasone R03AK10 Vilanterol and fluticasone furoate R03AK11 Formoterol and fluticasone R03AK12 Salmeterol and budesonide R03AK13 Salbutamol...

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Topical steroid

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acetonide 0.5% (Kenalog, Aristocort cream) Mometasone furoate 0.1% (Elocon, Elocom ointment) Fluticasone propionate 0.005% (Cutivate) Betamethasone dipropionate...

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Ellipta

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inhaler: Fluticasone furoate (Arnuity Ellipta, Relvar Ellipta) Fluticasone furoate/vilanterol (Breo Ellipta, Relvar Ellipta) Fluticasone furoate/umeclidinium...

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List of corticosteroids

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4-diene-3,20-dione Fluticasone = 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-21-thia-21-fluoromethylpregna-1,4-dien-3,20-dione Fluticasone furoate = 6α,9α-difluoro-11β...

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Betamethasone dipropionate

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Fluprednidene acetate Fluticasone Fluticasone furoate Fluticasone propionate Halometasone Meprednisone Mometasone Mometasone furoate Paramethasone Prednylidene...

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Budesonide

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(2002). "Acute Adrenal Crisis in Asthmatics Treated With High-Dose Fluticasone Propionate". Eur Respir J. 19 (6): 1207–9. doi:10.1183/09031936.02.00274402...

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Fluocinonide

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Fluprednidene acetate Fluticasone Fluticasone furoate Fluticasone propionate Halometasone Meprednisone Mometasone Mometasone furoate Paramethasone Prednylidene...

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Nasal spray

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Beclomethasone dipropionate Budesonide Ciclesonide Flunisolide Fluticasone furoate Fluticasone propionate Mometasone Triamcinolone acetonide Saline sprays...

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Glucocorticoid

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In this case, the main compounds used are beclometasone, budesonide, fluticasone, mometasone and ciclesonide. In rhinitis, sprays are used. For asthma...

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Clobetasol propionate

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Fluprednidene acetate Fluticasone Fluticasone furoate Fluticasone propionate Halometasone Meprednisone Mometasone Mometasone furoate Paramethasone Prednylidene...

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Triamcinolone acetonide

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Fluprednidene acetate Fluticasone Fluticasone furoate Fluticasone propionate Halometasone Meprednisone Mometasone Mometasone furoate Paramethasone Prednylidene...

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Prednisone

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Fluprednidene acetate Fluticasone Fluticasone furoate Fluticasone propionate Halometasone Meprednisone Mometasone Mometasone furoate Paramethasone Prednylidene...

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Fludrocortisone

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Fluprednidene acetate Fluticasone Fluticasone furoate Fluticasone propionate Halometasone Meprednisone Mometasone Mometasone furoate Paramethasone Prednylidene...

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Triamcinolone

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Fluprednidene acetate Fluticasone Fluticasone furoate Fluticasone propionate Halometasone Meprednisone Mometasone Mometasone furoate Paramethasone Prednylidene...

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List of corticosteroid esters

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Fluorometholone acetate Fluperolone acetate Fluprednidene acetate Fluticasone furoate Fluticasone propionate Formocortal (a corticosteroid 21-acetate ester)...

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Betamethasone

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Fluprednidene acetate Fluticasone Fluticasone furoate Fluticasone propionate Halometasone Meprednisone Mometasone Mometasone furoate Paramethasone Prednylidene...

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