Fibrillarin information

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Fibrillarin
Fibrillarin
	pyrococcus horikoshii fibrillarin pre-rrna processing protein
Identifiers
Symbol	Fibrillarin
Pfam	PF01269
Pfam clan	CL0063
InterPro	IPR000692
PROSITE	PDOC00489
SCOP2	1fbn / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

FBL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IPX
Identifiers
Aliases	FBL, FIB, FLRN, RNU3IP1, fibrillarin, Nop1
External IDs	OMIM: 134795; MGI: 95486; HomoloGene: 1099; GeneCards: FBL; OMA:FBL - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	39,846,379 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	27,878,694 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; left ovary; ; right ovary; ; skin of abdomen; ; skin of leg; ; canal of the cervix; ; ventricular zone; ; ectocervix; ; uterine tube; ; monocyte;
	Top expressed in
	epiblast; ; yolk sac; ; bone marrow; ; lens; ; ventricular zone; ; lip; ; spleen; ; thymus; ; tail of embryo; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; rRNA methyltransferase activity; ATPase binding; histone-glutamine methyltransferase activity; protein binding; TFIID-class transcription factor complex binding; RNA binding;
Cellular component	small-subunit processome; Cajal body; membrane; nucleolus; dense fibrillar component; extracellular exosome; nucleus; box C/D RNP complex; granular component; chromosome; nucleoplasm; fibrillar center;
Biological process	tRNA processing; snoRNA localization; rRNA methylation; histone glutamine methylation; methylation; box C/D RNA 3'-end processing; sno(s)RNA metabolic process; osteoblast differentiation; rRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	2091
	14113
	ENSG00000105202; ENSG00000280548
	ENSMUSG00000046865
	P22087
	P35550
	NM_001436
	NM_007991
	NP_001427
	NP_032017
	Wikidata
View/Edit Human	View/Edit Mouse

rRNA 2'-O-methyltransferase fibrillarin is an enzyme that in humans is encoded by the FBL gene.^[5]^[6]^[7]

^ ^a ^b ^c ENSG00000280548 GRCh38: Ensembl release 89: ENSG00000105202, ENSG00000280548 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046865 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Aris JP, Blobel G (Feb 1991). "cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera". Proceedings of the National Academy of Sciences of the United States of America. 88 (3): 931–5. Bibcode:1991PNAS...88..931A. doi:10.1073/pnas.88.3.931. PMC 50928. PMID 1846968.
^ Jansen RP, Hurt EC, Kern H, Lehtonen H, Carmo-Fonseca M, Lapeyre B, Tollervey D (May 1991). "Evolutionary conservation of the human nucleolar protein fibrillarin and its functional expression in yeast". The Journal of Cell Biology. 113 (4): 715–29. doi:10.1083/jcb.113.4.715. PMC 2288999. PMID 2026646.
^ "Entrez Gene: FBL fibrillarin".

[refGRCh38Ensembl-1] ENSG00000280548 GRCh38: Ensembl release 89: ENSG00000105202, ENSG00000280548 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046865 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1846968-5] Aris JP, Blobel G (Feb 1991). "cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera". Proceedings of the National Academy of Sciences of the United States of America. 88 (3): 931–5. Bibcode:1991PNAS...88..931A. doi:10.1073/pnas.88.3.931. PMC 50928. PMID 1846968.

[pmid2026646-6] Jansen RP, Hurt EC, Kern H, Lehtonen H, Carmo-Fonseca M, Lapeyre B, Tollervey D (May 1991). "Evolutionary conservation of the human nucleolar protein fibrillarin and its functional expression in yeast". The Journal of Cell Biology. 113 (4): 715–29. doi:10.1083/jcb.113.4.715. PMC 2288999. PMID 2026646.

[entrez-7] "Entrez Gene: FBL fibrillarin".

Fibrillarin information

and 27 Related for: Fibrillarin information

Fibrillarin

Nucleolus

Euglena

Fib

Cell nucleus

Small nucleolar RNA

Small nucleolar RNA TBR4

Small nucleolar RNA TBR2

FBL

USP36

Antinuclear antibody

C7orf50

Euglena gracilis

Small nucleolar RNA TBR6

Survival of motor neuron

DDX5

Stress granule

NOL12

Small nucleolar RNA TBR12

Small nucleolar RNA TBR7

TUBB1

NOL5A

Protein arginine methyltransferase 5

Small nucleolar RNA U3

UTP18

Small Cajal body specific RNA 6

UTP15