Protein arginine N-methyltransferase 5 is an enzyme that in humans is encoded by the PRMT5 gene.[5][6] PRMT5 symmetrically dimethylates H2AR3, H4R3, H3R2, and H3R8 in vivo, all of which are linked to a range of transcriptional regulatory events.[7]
PRMT5 is a highly conserved arginine methyltransferase that translocated from the cytoplasm to the nucleus at embryonic day ~E8.5, and during preimplantation development at the ~4-cell stage.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000100462 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000023110 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Gilbreth M, Yang P, Bartholomeusz G, et al. (Jan 1999). "Negative regulation of mitosis in fission yeast by the shk1 interacting protein skb1 and its human homolog, Skb1Hs". Proc Natl Acad Sci U S A. 95 (25): 14781–6. doi:10.1073/pnas.95.25.14781. PMC 24526. PMID 9843966.
^"Entrez Gene: PRMT5 protein arginine methyltransferase 5".
^Stopa N, Krebs JE, Shechter D (June 2015). "The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond". Cellular and Molecular Life Sciences. 72 (11): 2041–59. doi:10.1007/s00018-015-1847-9. PMC 4430368. PMID 25662273.
^Kim S, Gunesdogan, U, et al. (Nov 2014). "PRMT5 Protects Genomic Integrity during Global DNA Demethylation in Primordial Germ Cells and Preimplantation Embryos". Molecular Cell. 56 (4): 564–579. doi:10.1016/j.molcel.2014.10.003. PMC 4250265. PMID 25457166.
and 23 Related for: Protein arginine methyltransferase 5 information
Proteinarginine N-methyltransferase5 is an enzyme that in humans is encoded by the PRMT5 gene. PRMT5 symmetrically dimethylates H2AR3, H4R3, H3R2, and...
include proteinmethyltransferases, DNA/RNA methyltransferases, natural product methyltransferases, and non-SAM dependent methyltransferases. SAM is the...
side-chains of arginine and lysine, but also at the amino- and carboxy-termini of a number of different proteins. In biology, methyltransferases catalyze the...
Another post-translational modification of arginine involves methylation by proteinmethyltransferases. Arginine is the immediate precursor of nitric oxide...
interacts with proteinargininemethyltransferase5 (PRMT5), is essential for cell survival. It also recruits a SET2 histone methyltransferase (Huntingtin-interacting...
dimethylarginine), by proteinargininemethyltransferases (PRMTs). Lysine can be methylated once, twice, or three times by lysine methyltransferases. Protein methylation...
Proteinarginine N-methyltransferase 2 is an enzyme that in humans is encoded by the PRMT2 gene. The enzyme methylates final nitrogen atom of arginine...
the infant or individuals in severe catabolic distress. These six are arginine, cysteine, glycine, glutamine, proline, and tyrosine. Six amino acids are...
the amino acids lysine and arginine. One example of a protein which is commonly methylated is a histone. Histones are proteins found in the nucleus of the...
Protein detoxification is the process by which proteins containing methylated arginine are broken down and removed from the body. Arginine (Arg) is a non-essential...
Proteinarginine N-methyltransferase 1 is an enzyme that in humans is encoded by the PRMT1 gene. The HRMT1L2 gene encodes a proteinarginine methyltransferase...
histone 3 (H3K4me1), and arginine (R) residues on H3 and H4. Addition of methyl groups to histones by histone methyltransferases, can either activate or...
activation depending on the Tudor domain protein and context. For example, the human TDRD3 protein binds methylated arginine residues and promotes transcription...
Grimmler M (January 2011). "RioK1, a new interactor of proteinargininemethyltransferase5 (PRMT5), competes with pICln for binding and modulates PRMT5...
the enzyme betaine-homocysteine methyltransferase (E.C.2.1.1.5, BHMT). BHMT makes up to 1.5% of all the soluble protein of the liver, and recent evidence...
In biology, histones are highly basic proteins abundant in lysine and arginine residues that are found in eukaryotic cell nuclei and in most Archaeal phyla...
Proteinarginine N-methyltransferase 6 is an enzyme that in humans is encoded by the PRMT6 gene. Proteinarginine N-methyltransferases, such as PRMT6,...
Proteinargininemethyltransferase NDUFAF7, mitochondrial, also known as NADH:ubiquinone oxidoreductase complex assembly factor 7 (NDUFAF7), MidA, C2orf56...
increases in protein methylation occur predominantly at type I arginine methylation sites and involve proteinargininemethyltransferase 1". Journal of...
argininemethyltransferase-5 (PRMT5) protein. SmD3, SmB and SmD1 undergo post-translational modification in the methylosome. These three Sm proteins have...
C-terminus by a specific prenyl-protein specific endoprotease and the new C-terminus is methylated by a methyltransferase. KRas processing is completed...