NOL12 information

NOL12
Identifiers
Aliases	NOL12, Nop25, dJ37E16.7, nucleolar protein 12
External IDs	MGI: 2146285; HomoloGene: 32577; GeneCards: NOL12; OMA:NOL12 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	37,693,476 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	78,827,838 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; right testis; ; left testis; ; monocyte; ; mucosa of transverse colon; ; right hemisphere of cerebellum; ; right adrenal gland; ; granulocyte; ; left adrenal cortex; ; right adrenal cortex;
	Top expressed in
	interventricular septum; ; morula; ; internal carotid artery; ; fossa; ; blastocyst; ; embryo; ; epiblast; ; condyle; ; external carotid artery; ; embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	rRNA binding; protein binding; RNA binding; single-stranded DNA binding;
Cellular component	nucleolus; nucleus;
Biological process	rRNA processing; nucleolus organization; positive regulation of cell population proliferation; positive regulation of cell growth; negative regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	79159
	97961
	ENSG00000273899
	ENSMUSG00000033099
	Q9UGY1
	Q8BG17
	NM_024313
	NM_133800
	NP_077289
	NP_598561
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleolar protein 12 is a protein that in humans is encoded by the NOL12 gene.^[5]^[6] Human NOL12 has been shown to localize in the nucleolus and regulate nucleolar structure and homeostasis by maintaining the levels of multi-functional fibrillarin and nucleolin proteins. Its deficiency leads to p53 activation resulting in G2 arrest of cell. Nol12 or hNol12 drives p53 induced cell senescence suggesting its important role in aging.^[7] Human Nol12 is also required for ribosome maturation and genome integrity.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000273899 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033099 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
^ "Entrez Gene: NOL12 nucleolar protein 12".
^ Pinho M, Macedo JC, Logarinho E, Pereira PS (June 2019). "NOL12 Repression Induces Nucleolar Stress-Driven Cellular Senescence and Is Associated with Normative Aging". Molecular and Cellular Biology. 39 (12). doi:10.1128/MCB.00099-19. PMC 6549468. PMID 30988155.
^ Scott DD, Trahan C, Zindy PJ, Aguilar LC, Delubac MY, Van Nostrand EL, et al. (December 2017). "Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism". Nucleic Acids Research. 45 (21): 12509–12528. doi:10.1093/nar/gkx963. PMC 5716212. PMID 29069457.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000273899 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033099 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12477932-5] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[entrez-6] "Entrez Gene: NOL12 nucleolar protein 12".

[7] Pinho M, Macedo JC, Logarinho E, Pereira PS (June 2019). "NOL12 Repression Induces Nucleolar Stress-Driven Cellular Senescence and Is Associated with Normative Aging". Molecular and Cellular Biology. 39 (12). doi:10.1128/MCB.00099-19. PMC 6549468. PMID 30988155.

[8] Scott DD, Trahan C, Zindy PJ, Aguilar LC, Delubac MY, Van Nostrand EL, et al. (December 2017). "Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism". Nucleic Acids Research. 45 (21): 12509–12528. doi:10.1093/nar/gkx963. PMC 5716212. PMID 29069457.

NOL12 information

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NOL12

Chromosome 22

22q13 deletion syndrome