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Famciclovir information


Famciclovir
Clinical data
Pronunciation/ˌfæmˈsklˌvɪər/[1]
Trade namesFamvir
AHFS/Drugs.comMonograph
MedlinePlusa694038
Pregnancy
category
  • AU: B1
Routes of
administration
By mouth
ATC code
  • J05AB09 (WHO) S01AD07 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)[2]
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
Bioavailability75–77%
Protein binding20–25%
MetabolismLiver, circulation, intestinal wall (to penciclovir)
Elimination half-life2–2.3 hours
ExcretionKidney, faecal
Identifiers
IUPAC name
  • 2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate
CAS Number
  • 104227-87-4 checkY
PubChem CID
  • 3324
DrugBank
  • DB00426 checkY
ChemSpider
  • 3207 checkY
UNII
  • QIC03ANI02
KEGG
  • D00317 checkY
ChEBI
  • CHEBI:4974 checkY
ChEMBL
  • ChEMBL880 checkY
CompTox Dashboard (EPA)
  • DTXSID0023038 Edit this at Wikidata
ECHA InfoCard100.158.713 Edit this at Wikidata
Chemical and physical data
FormulaC14H19N5O4
Molar mass321.337 g·mol−1
3D model (JSmol)
  • Interactive image
Melting point103 °C (217 °F)
SMILES
  • O=C(OCC(COC(=O)C)CCn1c2nc(ncc2nc1)N)C
InChI
  • InChI=1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18) checkY
  • Key:GGXKWVWZWMLJEH-UHFFFAOYSA-N checkY
  (verify)

Famciclovir is a guanosine analogue antiviral drug used for the treatment of various herpesvirus infections, most commonly for herpes zoster (shingles). It is a prodrug form of penciclovir with improved oral bioavailability. Famciclovir is marketed under the trade name Famvir (Novartis).

Famciclovir was patented in 1983 and approved for medical use in 1994.[3][4] In 2007, the United States Food and Drug Administration approved the first generic version of famciclovir. Generic tablets are manufactured by TEVA Pharmaceuticals and Mylan Pharmaceuticals.[5][6]

  1. ^ "Famciclovir". Merriam-Webster.com Dictionary. Retrieved 2016-01-22.
  2. ^ "Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
  3. ^ Long SS, Pickering LK, Prober CG (2012). Principles and Practice of Pediatric Infectious Disease. Elsevier Health Sciences. p. 1502. ISBN 978-1437727029.
  4. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 504. ISBN 9783527607495.
  5. ^ "Recent Product Launches, Teva Pharmaceuticals USA". Archived from the original on 2011-11-08. Retrieved 2008-02-21.[better source needed]
  6. ^ "Mylan Launches Generic Version of Famvir® Tablets" (Press release). Mylan. 20 April 2011. Archived from the original on July 23, 2011. Retrieved 21 April 2011.

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Famciclovir

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Famciclovir is a guanosine analogue antiviral drug used for the treatment of various herpesvirus infections, most commonly for herpes zoster (shingles)...

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Herpetic whitlow

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has not been shown to be effective in management of herpetic whitlow. Famciclovir has been demonstrated to effectively treat and prevent recurrent episodes...

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Herpes

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therapy during the last months of pregnancy. The use of valaciclovir and famciclovir, while potentially improving compliance, have less-well-determined safety...

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Keratitis

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to identify the pathogen). Topical ganciclovir or oral valacyclovir, famciclovir or acyclovir are used for HSV keratitis. Steroids should be avoided as...

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Varicella zoster virus

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of drugs and therapeutic agents including acyclovir for chickenpox, famciclovir, valaciclovir for the shingles, zoster-immune globulin (ZIG), and vidarabine...

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Novartis

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tablets for oral use are marketed under the brand name Jadenu Famvir (famciclovir) Herpes zoster and other Herpesvirus infection Fanapt (iloperidone) Schizophrenia...

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Cold sore

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much as 10%. Oral antivirals include acyclovir, valaciclovir, and famciclovir. Famciclovir or valacyclovir, taken in pill form, can be effective using a single...

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Viral disease

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Congenital varicella syndrome Varicella: acyclovir famciclovir valacyclovir Zoster: acyclovir famciclovir Varicella: varicella vaccine varicella-zoster immunoglobulin...

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Penciclovir

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cold sore medications Denavir (NDC 0135-0315-52), Vectavir and Fenivir. Famciclovir is a prodrug of penciclovir with improved oral bioavailability. Penciclovir...

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List of antiviral drugs

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inhibitor Entecavir HIV NRTI 2005 Etravirine (Intelence) HIV NNRTI 2008 Famciclovir Herpes Zoster Guanosine analogue 1994 Fomivirsen AIDS Anti-sense oligonucleotide...

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Schedule H

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DISODIUM 189. ETODOLAC 190. ETOMIDATE 191. ETOPOSIDE 192. EXEMESTANE 193. FAMCICLOVIR 194. FAMOTIDINE 195. FENBENDAZOLE 196. FENOFIBRATE 197. FEXOFENADINE...

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Nucleoside analogue

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usually overcome by switching to another drug of the same kind (e.g. famciclovir, penciclovir, valaciclovir). Nucleoside analogue drugs include: deoxyadenosine...

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Multiple drug resistance

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to acyclovir preparations, mostly in the form of cross-resistance to famciclovir and valacyclovir, usually in immunosuppressed patients. The prime example...

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Teva Pharmaceuticals

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Epoprostenol Sodium Errin Escitalopram Estazolam Estradiol Etodolac Famciclovir Fentanyl Filgrastim Finasteride Fiorinal Flunitrazepam Fluocinonide Fluconazole...

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Ramsay Hunt syndrome type 2

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prednisone and an antiviral drug such as acyclovir, valacyclovir or famciclovir for 5 to 7 days is standard; however, some studies have shown later damage...

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Feline viral rhinotracheitis

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promise for treatment. More recent research has indicated that systemic famciclovir is effective at treating this infection in cats without the side effects...

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Thymidine kinase from herpesvirus

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only. Such antivirals include: Purine analogues of guanine: Aciclovir, Famciclovir, Ganciclovir, Penciclovir, Valaciclovir, Valganciclovir Vidarabine Pyrimidine...

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Shingles

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has been the standard treatment, but the newer drugs valaciclovir and famciclovir demonstrate similar or superior efficacy and good safety and tolerability...

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Ganciclovir

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2022). "Comparative Efficacy of Topical Ophthalmic Ganciclovir and Oral Famciclovir in Cats with Experimental Ocular Feline Herpesvirus-1 Epithelial Infection"...

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Herpetic gingivostomatitis

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to treat herpetic gingivostomatitis such as aciclovir, valaciclovir, famciclovir, and in resistance cases foscarnet can be used. Treatment does not prevent...

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Cochlear hydrops

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Iqbal Z. Randomized double-blinded, placebo-controlled clinical trial of famciclovir for reduction of Ménière's disease symptoms. Otolaryngol Head Neck Surg...

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Postherpetic neuralgia

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one RCT included in the meta-analysis that compared placebo to oral famciclovir treatment within 72 hours of HZ rash onset. Studies using valaciclovir...

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Varicella vaccine

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appropriate treatment. Specific antiviral medication, such as acyclovir, famciclovir, or valacyclovir, are not recommended 24 hours before and 14 days after...

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Herpes simplex virus

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patients who were receiving anti-herpetic medications (e.g., acyclovir, famciclovir, ganciclovir, idoxuridine, penciclovir, tromantadine, valaciclovir, or...

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Elephant endotheliotropic herpesvirus

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mouth ulcers, and oedema of the head and trunk. Rapid treatment with famciclovir, sustained for around a month, has appeared to cure eight calves infected...

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ATC code S01

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Trifluridine S01AD03 Aciclovir S01AD05 Interferon S01AD06 Vidarabine S01AD07 Famciclovir S01AD08 Fomivirsen S01AD09 Ganciclovir S01AE01 Ofloxacin S01AE02 Norfloxacin...

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