Immune response to nonself antigens from members of the same species
Alloimmunity (sometimes called isoimmunity) is an immune response to nonself antigens from members of the same species, which are called alloantigens or isoantigens. Two major types of alloantigens are blood group antigens[1] and histocompatibility antigens. In alloimmunity, the body creates antibodies (called alloantibodies) against the alloantigens, attacking transfused blood, allotransplanted tissue, and even the fetus in some cases. Alloimmune (isoimmune) response results in graft rejection, which is manifested as deterioration or complete loss of graft function. In contrast, autoimmunity is an immune response to the self's own antigens. (The allo- prefix means "other", whereas the auto- prefix means "self".) Alloimmunization (isoimmunization) is the process of becoming alloimmune, that is, developing the relevant antibodies for the first time.
Alloimmunity is caused by the difference between products of highly polymorphic genes, primarily genes of the major histocompatibility complex, of the donor and graft recipient. These products are recognized by T-lymphocytes and other mononuclear leukocytes which infiltrate the graft and damage it.
^Isoantigen Archived 2016-10-09 at the Wayback Machine at eMedicine Dictionary
Alloimmunity (sometimes called isoimmunity) is an immune response to nonself antigens from members of the same species, which are called alloantigens or...
The spectrum of target antigens associated with tumor immunity and alloimmunity after allogeneic HSCT: Host-derived T and B cells can be induced to recognize...
attacking the patient's RBCs. This mechanism could be autoimmunity, alloimmunity or a drug-induced immune-mediated mechanism. Hemolytic disease of the...
placental insufficiency and/or fetal hypoxia. Other causes, such as alloimmunity, genetics, autoimmunity, and infection, are less frequent. Thrombocytopenia...
g. HbH disease Systemic conditions Sepsis Arteriovenous malformation Alloimmunity (The neonatal or cord blood gives a positive direct Coombs test and the...
Immune-mediated hemolytic reactions, such as DHTR, represent a type of alloimmunity. Non-immune hemolysis may result from thermal, osmotic, or mechanical...
termed "natural autoimmunity"). Autoimmunity should not be confused with alloimmunity. While a high level of autoimmunity is unhealthy, a low level of autoimmunity...
individuals can produce IgG-type ABO antibodies. ABO blood group system Alloimmunity Antibodies Branch, Donald R. (2015). "Anti-A and anti-B: what are they...
(2004). "Toll-like receptors and other links between innate and acquired alloimmunity". Current Opinion in Immunology. 16 (5): 538–544. doi:10.1016/j.coi.2004...
that TNX-1500 monotherapy consistently and safely prevented pathologic alloimmunity in non-human promate cardiac and kidney allograft models, as well as...
laboratory showed that coronin 1 signaling plays a crucial role in auto- and alloimmunity and that coronin-mediated signaling underlies the longevity of T cells...
investigations have also demonstrated the connection between TG and humoral alloimmunity.TG is first thought to be the characteristic lesion of chronic ABMR....
(October 2013). "Immune cell-derived C3a and C5a costimulate human T cell alloimmunity". American Journal of Transplantation. 13 (10): 2530–9. doi:10.1111/ajt...
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