ISLR information

ISLR
Identifiers
Aliases	ISLR, HsT17563, Meflin, immunoglobulin superfamily containing leucine-rich repeat, immunoglobulin superfamily containing leucine rich repeat
External IDs	OMIM: 602059 MGI: 1349645 HomoloGene: 4050 GeneCards: ISLR
Gene location (Human)
Chr.	Chromosome 15 (human)
End	74,176,872 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	58,111,589 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; canal of the cervix; ; stromal cell of endometrium; ; myometrium; ; right coronary artery; ; left uterine tube; ; gallbladder; ; popliteal artery; ; vagina; ; ascending aorta;
	Top expressed in
	calvaria; ; optic nerve; ; internal carotid artery; ; aortic valve; ; external carotid artery; ; ascending aorta; ; median eminence; ; body of femur; ; molar; ; dermis;
	More reference expression data
	n/a
Orthologs
	3671
	26968
	ENSG00000129009; ENSG00000288508
	ENSMUSG00000037206
	O14498
	Q6GU68
	NM_201526; NM_005545
	NM_001195431; NM_012043
	NP_005536; NP_958934
	NP_001182360; NP_036173
	Wikidata
View/Edit Human	View/Edit Mouse

In humans, the immunoglobulin super family containing leucine-rich repeat (ISLR) protein is encoded by the ISLR gene.^[5] Current RNA-seq studies show that the protein is highly expressed in the endometrium and ovary and shows expression among 25 other tissues.^[6] The protein is seen localized in the cytoplasm,^[7] plasma membrane,^[8] extracellular exosome,^[9] and platelet alpha granule lumen.^[5] Furthermore, the protein is known to play a role in platelet degranulation,^[5] cell adhesion,^[10] and response to elevated platelet cytosolic Ca²⁺.^[11]

^ ^a ^b ^c ENSG00000288508 GRCh38: Ensembl release 89: ENSG00000129009, ENSG00000288508 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037206 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c "ISLR immunoglobulin superfamily containing leucine rich repeat [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Archived from the original on 23 September 2020. Retrieved 2 August 2020.
^ "ISLR immunoglobulin superfamily containing leucine rich repeat [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Archived from the original on 23 September 2020. Retrieved 2 August 2020.
^ "ISLR Primary Antibodies". www.thermofisher.com. Archived from the original on 23 September 2020. Retrieved 2 August 2020.
^ "ISLR Antibody (PA5-65263)". www.thermofisher.com. Archived from the original on 23 September 2020. Retrieved 2 August 2020.
^ Principe S, Jones EE, Kim Y, Sinha A, Nyalwidhe JO, Brooks J, et al. (May 2013). "In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine". Proteomics. 13 (10–11): 1667–1671. doi:10.1002/pmic.201200561. PMC 3773505. PMID 23533145.
^ Nagasawa A, Kubota R, Imamura Y, Nagamine K, Wang Y, Asakawa S, et al. (September 1997). "Cloning of the cDNA for a new member of the immunoglobulin superfamily (ISLR) containing leucine-rich repeat (LRR)". Genomics. 44 (3): 273–9. doi:10.1006/geno.1997.4889. PMID 9325048. Archived from the original on 23 September 2020. Retrieved 2 August 2020.
^ "ISLR Gene - GeneCards | ISLR Protein | ISLR Antibody". www.genecards.org. Archived from the original on 17 September 2017. Retrieved 2 August 2020.

[refGRCh38Ensembl-1] ENSG00000288508 GRCh38: Ensembl release 89: ENSG00000129009, ENSG00000288508 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037206 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-5] "ISLR immunoglobulin superfamily containing leucine rich repeat [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Archived from the original on 23 September 2020. Retrieved 2 August 2020.

[6] "ISLR immunoglobulin superfamily containing leucine rich repeat [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Archived from the original on 23 September 2020. Retrieved 2 August 2020.

[:7-7] "ISLR Primary Antibodies". www.thermofisher.com. Archived from the original on 23 September 2020. Retrieved 2 August 2020.

[8] "ISLR Antibody (PA5-65263)". www.thermofisher.com. Archived from the original on 23 September 2020. Retrieved 2 August 2020.

[9] Principe S, Jones EE, Kim Y, Sinha A, Nyalwidhe JO, Brooks J, et al. (May 2013). "In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine". Proteomics. 13 (10–11): 1667–1671. doi:10.1002/pmic.201200561. PMC 3773505. PMID 23533145.

[:3-10] Nagasawa A, Kubota R, Imamura Y, Nagamine K, Wang Y, Asakawa S, et al. (September 1997). "Cloning of the cDNA for a new member of the immunoglobulin superfamily (ISLR) containing leucine-rich repeat (LRR)". Genomics. 44 (3): 273–9. doi:10.1006/geno.1997.4889. PMID 9325048. Archived from the original on 23 September 2020. Retrieved 2 August 2020.

[:4-11] "ISLR Gene - GeneCards | ISLR Protein | ISLR Antibody". www.genecards.org. Archived from the original on 17 September 2017. Retrieved 2 August 2020.

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