ID4 information

ID4
Identifiers
Aliases	ID4, IDB4, bHLHb27, inhibitor of DNA binding 4, HLH protein
External IDs	OMIM: 600581; MGI: 99414; HomoloGene: 1186; GeneCards: ID4; OMA:ID4 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	19,842,197 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	48,419,502 bp
RNA expression pattern
	Top expressed in
	skin of hip; ; skin of thigh; ; ventricular zone; ; germinal epithelium; ; optic nerve; ; hair follicle; ; urethra; ; thyroid gland; ; seminal vesicula; ; left lobe of thyroid gland;
	Top expressed in
	olfactory tubercle; ; Rostral migratory stream; ; optic nerve; ; medial dorsal nucleus; ; lateral septal nucleus; ; supraoptic nucleus; ; nucleus accumbens; ; aortic valve; ; globus pallidus; ; utricle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein dimerization activity; transcription corepressor activity; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity; transcription factor binding;
Cellular component	cytoplasm; nucleus;
Biological process	prostate gland stromal morphogenesis; negative regulation of fat cell differentiation; negative regulation of astrocyte differentiation; regulation of transcription, DNA-templated; negative regulation of neuron differentiation; central nervous system myelination; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; seminal vesicle morphogenesis; brain development; positive regulation of gene expression; positive regulation of osteoblast differentiation; prostate gland epithelium morphogenesis; negative regulation of oligodendrocyte differentiation; circadian rhythm; positive regulation of cell population proliferation; prostate gland morphogenesis; neuroblast proliferation; cerebral cortex neuron differentiation; cell population proliferation; negative regulation of transcription, DNA-templated; hippocampus development; fat cell differentiation; positive regulation of transcription by RNA polymerase II; G1/S transition of mitotic cell cycle; neuron differentiation; negative regulation of DNA binding; regulation of cell cycle; osteoblast differentiation;
	Sources:Amigo / QuickGO
Orthologs
	3400
	15904
	ENSG00000172201
	ENSMUSG00000021379
	P47928
	P41139
	NM_001546
	NM_031166
	NP_001537
	NP_112443
	Wikidata
View/Edit Human	View/Edit Mouse

ID4 is a protein coding gene. In humans, it encodes the protein known as DNA-binding protein inhibitor ID-4.^[5]^[6] This protein is known to be involved in the regulation of many cellular processes during both prenatal development and tumorigenesis. This is inclusive of embryonic cellular growth, senescence, cellular differentiation, apoptosis, and as an oncogene in angiogenesis.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172201 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021379 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pagliuca A, Bartoli PC, Saccone S, Della Valle G, Lania L (Oct 1995). "Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22". Genomics. 27 (1): 200–3. doi:10.1006/geno.1995.1026. PMID 7665172.
^ "Entrez Gene: ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein".
^ "Atlas of Genetics and Cytogenetics in Oncology and Haematology".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172201 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021379 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7665172-5] Pagliuca A, Bartoli PC, Saccone S, Della Valle G, Lania L (Oct 1995). "Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22". Genomics. 27 (1): 200–3. doi:10.1006/geno.1995.1026. PMID 7665172.

[entrez-6] "Entrez Gene: ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein".

[atl123-7] "Atlas of Genetics and Cytogenetics in Oncology and Haematology".

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