GLIS1 information

GLIS1
Identifiers
Aliases	GLIS1, GLIS family zinc finger 1
External IDs	OMIM: 610378; MGI: 2386723; HomoloGene: 77390; GeneCards: GLIS1; OMA:GLIS1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	53,739,164 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	107,492,258 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; seminal vesicula; ; prostate; ; canal of the cervix; ; testicle; ; primary visual cortex; ; right hemisphere of cerebellum; ; retinal pigment epithelium; ; ectocervix; ; gastric mucosa;
	Top expressed in
	zygote; ; secondary oocyte; ; right kidney; ; primary oocyte; ; gastrula; ; labioscrotal swelling; ; proximal tubule; ; female urethra; ; morula; ; male urethra;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific; DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; transcription by RNA polymerase II; osteoblast differentiation; negative regulation of cell fate commitment; fat cell differentiation; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	148979
	230587
	ENSG00000174332
	ENSMUSG00000034762
	Q8NBF1
	Q8K1M4
	NM_147193; NM_001367484; NM_001390836; NM_001390837; NM_001390838
	NM_147221
	NP_671726; NP_001354413
	NP_671754
	Wikidata
View/Edit Human	View/Edit Mouse

Glis1 (Glis Family Zinc Finger 1) is gene encoding a Krüppel-like protein of the same name whose locus is found on Chromosome 1p32.3.^[5]^[6] The gene is enriched in unfertilised eggs and embryos at the one cell stage^[7] and it can be used to promote direct reprogramming of somatic cells to induced pluripotent stem cells, also known as iPS cells.^[7] Glis1 is a highly promiscuous transcription factor, regulating the expression of numerous genes, either positively or negatively. In organisms, Glis1 does not appear to have any directly important functions. Mice whose Glis1 gene has been removed have no noticeable change to their phenotype.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174332 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034762 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GLIS family zinc finger 1".
^ Kim YS, Lewandoski M, Perantoni AO, Kurebayashi S, Nakanishi G, Jetten AM (August 2002). "Identification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functions". J. Biol. Chem. 277 (34): 30901–13. doi:10.1074/jbc.M203563200. PMID 12042312.
^ ^a ^b Maekawa M, Yamaguchi K, Nakamura T, Shibukawa R, Kodanaka I, Ichisaka T, Kawamura Y, Mochizuki H, Goshima N, Yamanaka S (June 2011). "Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1". Nature. 474 (7350): 225–9. doi:10.1038/nature10106. hdl:2433/141930. PMID 21654807. S2CID 4428172.*Lay summary in: Tiu G (June 9, 2011). "Stem Cell Pioneer Yamanaka Discovers New Factor, Glis1, For iPS Cell Production". AsianScientist.
^ Kang HS, ZeRuth G, Lichti-Kaiser K, Vasanth S, Yin Z, Kim YS, Jetten AM (November 2010). "Gli-similar (Glis) Krüppel-like zinc finger proteins: insights into their physiological functions and critical roles in neonatal diabetes and cystic renal disease". Histol. Histopathol. 25 (11): 1481–96. PMC 2996882. PMID 20865670.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174332 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034762 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GLIS family zinc finger 1".

[Kim_2002-6] Kim YS, Lewandoski M, Perantoni AO, Kurebayashi S, Nakanishi G, Jetten AM (August 2002). "Identification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functions". J. Biol. Chem. 277 (34): 30901–13. doi:10.1074/jbc.M203563200. PMID 12042312.

[Maekawa_2011-7] Maekawa M, Yamaguchi K, Nakamura T, Shibukawa R, Kodanaka I, Ichisaka T, Kawamura Y, Mochizuki H, Goshima N, Yamanaka S (June 2011). "Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1". Nature. 474 (7350): 225–9. doi:10.1038/nature10106. hdl:2433/141930. PMID 21654807. S2CID 4428172.*Lay summary in: Tiu G (June 9, 2011). "Stem Cell Pioneer Yamanaka Discovers New Factor, Glis1, For iPS Cell Production". AsianScientist.

[Kang_2010-8] Kang HS, ZeRuth G, Lichti-Kaiser K, Vasanth S, Yin Z, Kim YS, Jetten AM (November 2010). "Gli-similar (Glis) Krüppel-like zinc finger proteins: insights into their physiological functions and critical roles in neonatal diabetes and cystic renal disease". Histol. Histopathol. 25 (11): 1481–96. PMC 2996882. PMID 20865670.

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List of human transcription factors

Induced pluripotent stem cell

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USF1