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FLI1 information


FLI1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFLI1, EWSR2, SIC-1, Fli-1 proto-oncogene, ETS transcription factor, BDPLT21, FLI-1
External IDsOMIM: 193067; MGI: 95554; HomoloGene: 55624; GeneCards: FLI1; OMA:FLI1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001167681
NM_001271010
NM_001271012
NM_002017

NM_008026

RefSeq (protein)

NP_001161153
NP_001257939
NP_001257941
NP_002008
NP_001161153.1

NP_032052

Location (UCSC)Chr 11: 128.69 – 128.81 MbChr 9: 32.33 – 32.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Friend leukemia integration 1 transcription factor (FLI1), also known as transcription factor ERGB, is a protein that in humans is encoded by the FLI1 gene, which is a proto-oncogene.[5][6][7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151702 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000016087 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Baud V, Lipinski M, Rassart E, Poliquin L, Bergeron D (September 1991). "The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24". Genomics. 11 (1): 223–4. doi:10.1016/0888-7543(91)90124-W. PMID 1765382.
  6. ^ Prasad DD, Rao VN, Reddy ES (October 1992). "Structure and expression of human Fli-1 gene". Cancer Research. 52 (20): 5833–7. PMID 1394211.
  7. ^ Rao VN, Ohno T, Prasad DD, Bhattacharya G, Reddy ES (August 1993). "Analysis of the DNA-binding and transcriptional activation functions of human Fli-1 protein". Oncogene. 8 (8): 2167–73. PMID 8336942.

and 25 Related for: FLI1 information

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FLI1

Last Update:

integration 1 transcription factor (FLI1), also known as transcription factor ERGB, is a protein that in humans is encoded by the FLI1 gene, which is a proto-oncogene...

Word Count : 2014

Ewing sarcoma

Last Update:

Friend Leukemia Virus Integration 1 (FLI1) gene (which encodes Friend Leukemia Integration 1 transcription factor (FLI1), a member of the ETS transcription...

Word Count : 4430

DMRT1

Last Update:

Tryptophan clusters ELF 2 4 5 EGF ELK 1 3 4 ERF ETS 1 2 ERG SPIB ETV 1 4 5 6 FLI1 Interferon regulatory factors 1 2 3 4 5 6 7 8 MYB MYBL2 (3.6) TEA domain...

Word Count : 1641

Down syndrome

Last Update:

Leukemia/lymphoma Other Ewing sarcoma t(11 FLI1; 22 EWS) Synovial sarcoma t(x SYT;18 SSX) Dermatofibrosarcoma protuberans t(17 COL1A1;22 PDGFB) Myxoid...

Word Count : 14996

Sarcoma

Last Update:

This results in the EWSR1 gene becoming fused to other genes, including the FLI1 gene in 90% of Ewing cases and ERG gene in 5-10% of cases. These fusions...

Word Count : 4084

SAP1a

Last Update:

response elements (SRE) located in the c-fos promoter. ELK1, SAPla, FLI1 and EWS-FLI1 are able to form ternary complexes with SRF on EGR1 SREs. In addition...

Word Count : 417

Chromosomal translocation

Last Update:

Anaplastic large cell lymphoma ALK NPM1 t(11;22)(q24;q11.2-12) Ewing's sarcoma FLI1 EWS t(17;22) DFSP Collagen I on chromosome 17 Platelet derived growth factor...

Word Count : 1523

Ewing family of tumors

Last Update:

of the EWS gene on chromosome 22 to an ETS-type gene, most commonly the FLI1 gene.  EFTs are highly malignant, with 5-year survival for patients with...

Word Count : 904

Turner syndrome

Last Update:

Leukemia/lymphoma Other Ewing sarcoma t(11 FLI1; 22 EWS) Synovial sarcoma t(x SYT;18 SSX) Dermatofibrosarcoma protuberans t(17 COL1A1;22 PDGFB) Myxoid...

Word Count : 9205

Birth defect

Last Update:

Leukemia/lymphoma Other Ewing sarcoma t(11 FLI1; 22 EWS) Synovial sarcoma t(x SYT;18 SSX) Dermatofibrosarcoma protuberans t(17 COL1A1;22 PDGFB) Myxoid...

Word Count : 10067

Microsatellite

Last Update:

Raynal V, Surdez D, Aynaud MM, et al. (September 2015). "Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite"...

Word Count : 7384

Epithelioid sarcoma

Last Update:

antigen, and CD34, whereas they are usually negative for S100, desmin, and FLI1 (FLI-1). They characteristically lack the protein INI1 (see below). Epithelioid...

Word Count : 5913

FET protein family

Last Update:

with part of the FLI1 ETS transcription factor family gene normally located on band 24 of the long arm of chromosome 11. The EWSR1-FLI1 fusion gene encodes...

Word Count : 2705

Miscarriage

Last Update:

Leukemia/lymphoma Other Ewing sarcoma t(11 FLI1; 22 EWS) Synovial sarcoma t(x SYT;18 SSX) Dermatofibrosarcoma protuberans t(17 COL1A1;22 PDGFB) Myxoid...

Word Count : 10911

Trabectedin

Last Update:

(February 2011). "Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cells". Neoplasia. 13 (2): 145–153. doi:10.1593/neo.101202...

Word Count : 1749

Homeobox

Last Update:

Tryptophan clusters ELF 2 4 5 EGF ELK 1 3 4 ERF ETS 1 2 ERG SPIB ETV 1 4 5 6 FLI1 Interferon regulatory factors 1 2 3 4 5 6 7 8 MYB MYBL2 (3.6) TEA domain...

Word Count : 4469

Zinc finger

Last Update:

Tryptophan clusters ELF 2 4 5 EGF ELK 1 3 4 ERF ETS 1 2 ERG SPIB ETV 1 4 5 6 FLI1 Interferon regulatory factors 1 2 3 4 5 6 7 8 MYB MYBL2 (3.6) TEA domain...

Word Count : 4825

List of human transcription factors

Last Update:

specific TF according to literature or domain structure – No motif [232] FLI1 ENSG00000151702 Ets Known motif – High-throughput in vitro [233] RCCGGAWRY...

Word Count : 81

CREB

Last Update:

Tryptophan clusters ELF 2 4 5 EGF ELK 1 3 4 ERF ETS 1 2 ERG SPIB ETV 1 4 5 6 FLI1 Interferon regulatory factors 1 2 3 4 5 6 7 8 MYB MYBL2 (3.6) TEA domain...

Word Count : 2243

Transcription factor

Last Update:

Tryptophan clusters ELF 2 4 5 EGF ELK 1 3 4 ERF ETS 1 2 ERG SPIB ETV 1 4 5 6 FLI1 Interferon regulatory factors 1 2 3 4 5 6 7 8 MYB MYBL2 (3.6) TEA domain...

Word Count : 8023

William Vainchenker

Last Update:

F, Debili N, Feunteun J, Danos O, Albagli O, Vainchenker W, Favier R., « FLI1 monoallelic expression combined with its hemizygous loss underlies Paris-Trousseau/Jacobsen...

Word Count : 1821

Hormone receptor

Last Update:

Tryptophan clusters ELF 2 4 5 EGF ELK 1 3 4 ERF ETS 1 2 ERG SPIB ETV 1 4 5 6 FLI1 Interferon regulatory factors 1 2 3 4 5 6 7 8 MYB MYBL2 (3.6) TEA domain...

Word Count : 1999

P53

Last Update:

Tryptophan clusters ELF 2 4 5 EGF ELK 1 3 4 ERF ETS 1 2 ERG SPIB ETV 1 4 5 6 FLI1 Interferon regulatory factors 1 2 3 4 5 6 7 8 MYB MYBL2 (3.6) TEA domain...

Word Count : 13103

Myc

Last Update:

Tryptophan clusters ELF 2 4 5 EGF ELK 1 3 4 ERF ETS 1 2 ERG SPIB ETV 1 4 5 6 FLI1 Interferon regulatory factors 1 2 3 4 5 6 7 8 MYB MYBL2 (3.6) TEA domain...

Word Count : 6709

Nuclear receptor

Last Update:

Tryptophan clusters ELF 2 4 5 EGF ELK 1 3 4 ERF ETS 1 2 ERG SPIB ETV 1 4 5 6 FLI1 Interferon regulatory factors 1 2 3 4 5 6 7 8 MYB MYBL2 (3.6) TEA domain...

Word Count : 6675

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