Eprotirome information

Eprotirome
Identifiers
	IUPAC name 2-({3,5-Dibromo-4-[4-hydroxy-3-(propan-2-yl)phenoxy]phenyl}carbamoyl)acetic acid;
CAS Number	355129-15-6;
PubChem CID	10299876;
DrugBank	DB05035;
ChemSpider	8475344;
UNII	958AQ7B6R1;
ChEMBL	ChEMBL2035874;
CompTox Dashboard (EPA)	DTXSID00189021 ;
Chemical and physical data
Formula	C18H17Br2N2O5
Molar mass	501.151 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)C1=C(C=CC(=C1)OC2=C(C=C(C=C2Br)NC(=O)CC(=O)O)Br)O;
	InChI InChI=1S/C18H17Br2NO5/c1-9(2)12-7-11(3-4-15(12)22)26-18-13(19)5-10(6-14(18)20)21-16(23)8-17(24)25/h3-7,9,22H,8H2,1-2H3,(H,21,23)(H,24,25); Key:VPCSYAVXDAUHLT-UHFFFAOYSA-N;

Eprotirome is a thyromimetic drug that has been investigated for the treatment of dyslipidemia. A Phase III trial in humans was discontinued after the drug was found to have negative effects on cartilage in dogs.^[1]^[2]

^ Saponaro, Federica; Sestito, Simona; Runfola, Massimiliano; Rapposelli, Simona; Chiellini, Grazia (2020). "Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders". Frontiers in Medicine. 7: 331. doi:10.3389/fmed.2020.00331. ISSN 2296-858X. PMC 7363807. PMID 32733906.
^ Unnikrishnan, A. G.; Baruah, Manash; Kalra, Sanjay (December 2012). "Thyromimetics: What does the future hold?". Indian Journal of Endocrinology and Metabolism. 16 (Suppl 2): S159–S161. doi:10.4103/2230-8210.104029. ISSN 2230-8210. PMC 3603016. PMID 23565368.

[1] Saponaro, Federica; Sestito, Simona; Runfola, Massimiliano; Rapposelli, Simona; Chiellini, Grazia (2020). "Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders". Frontiers in Medicine. 7: 331. doi:10.3389/fmed.2020.00331. ISSN 2296-858X. PMC 7363807. PMID 32733906.

[2] Unnikrishnan, A. G.; Baruah, Manash; Kalra, Sanjay (December 2012). "Thyromimetics: What does the future hold?". Indian Journal of Endocrinology and Metabolism. 16 (Suppl 2): S159–S161. doi:10.4103/2230-8210.104029. ISSN 2230-8210. PMC 3603016. PMID 23565368.

Eprotirome information

and 27 Related for: Eprotirome information

Eprotirome

Iodine

Propranolol

Thioamide

Levothyroxine

Desiccated thyroid extract

Thioureas

Resmetirom

Antithyroid agent

Thiamazole

Selenium

Thyroid hormones

Thyroid peroxidase

Carbimazole

Tyrosine

Propylthiouracil

Liothyronine

Thyroglobulin

Thiocyanate

Thyromimetic

Thiourea

Perchlorate

Potassium perchlorate

Iodothyronine deiodinase

Triiodothyronine

Transthyretin

Genistein

Identifiers

IUPAC name 2-({3,5-Dibromo-4-[4-hydroxy-3-(propan-2-yl)phenoxy]phenyl}carbamoyl)acetic acid
CAS Number	355129-15-6
PubChem CID	10299876
DrugBank	DB05035
ChemSpider	8475344
UNII	958AQ7B6R1
ChEMBL	ChEMBL2035874
CompTox Dashboard (EPA)	DTXSID00189021
Chemical and physical data
Formula	C₁₈H₁₇Br₂N₂O₅
Molar mass	501.151 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC(C)C1=C(C=CC(=C1)OC2=C(C=C(C=C2Br)NC(=O)CC(=O)O)Br)O
InChI InChI=1S/C18H17Br2NO5/c1-9(2)12-7-11(3-4-15(12)22)26-18-13(19)5-10(6-14(18)20)21-16(23)8-17(24)25/h3-7,9,22H,8H2,1-2H3,(H,21,23)(H,24,25) Key:VPCSYAVXDAUHLT-UHFFFAOYSA-N