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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Genistein (C15H10O5) is a naturally occurring compound that structurally belongs to a class of compounds known as isoflavones. It is described as an angiogenesis inhibitor and a phytoestrogen.[1]
It was first isolated in 1899 from the dyer's broom, Genista tinctoria; hence, the chemical name. The compound structure was established in 1926, when it was found to be identical with that of prunetol. It was chemically synthesized in 1928.[2] It has been shown to be the primary secondary metabolite of the Trifolium species and Glycine max.[3]
^Sail, Vibhavari; Hadden, M. Kyle (2012-01-01), Desai, Manoj C. (ed.), Chapter Eighteen - Notch Pathway Modulators as Anticancer Chemotherapeutics, Annual Reports in Medicinal Chemistry, vol. 47, Academic Press, pp. 267–280, doi:10.1016/B978-0-12-396492-2.00018-7, retrieved 2020-09-14
^Walter, E. D. (1941). "Genistin (an Isoflavone Glucoside) and its Aglucone, Genistein, from Soybeans". Journal of the American Chemical Society. 63 (12): 3273–76. doi:10.1021/ja01857a013.
^Popiołkiewicz, Joanna; Polkowski, Krzysztof; Skierski, Janusz S.; Mazurek, Aleksander P. (November 2005). "In vitro toxicity evaluation in the development of new anticancer drugs—genistein glycosides". Cancer Letters. 229 (1): 67–75. doi:10.1016/j.canlet.2005.01.014. ISSN 0304-3835. PMID 16157220.
Genistein (C15H10O5) is a naturally occurring compound that structurally belongs to a class of compounds known as isoflavones. It is described as an angiogenesis...
to its aglycone form, genistein. It is hydrolyzed by removing the covalently bound glucose to form genistein and that genistein is the form of the compound...
known to be regulated by Genistein, an isoflavone that is naturally found in a number of plants. It was first proven that genistein inhibits the activity...
source of isoflavones in human food; the major isoflavones in soybean are genistein and daidzein. The phenylpropanoid pathway begins from the amino acid phenylalanine...
aglycones genistein, quercetin and kaempferol. Another analysis found genistein and genistein glycosides including sophorabioside, sophoricoside, genistein-7-diglucoside...
disease may be alleviated by an adequate dose of genistein. Despite its reported beneficial properties, genistein also has toxic side effects. Several support...
differential effects in a dose-dependent way. The final biological effects of genistein are determined by the balance among these pleiotrophic actions. Phytoestrogens...
low water solubility. Daidzein and other isoflavone compounds, such as genistein, are present in a number of plants and herbs like kwao krua (Pueraria...
Sophoricoside is an isoflavone Genistein glycoside found in the dried ripe fruit of Styphnolobium japonicum (L.) Schott, a herb used in traditional Chinese...
also provides a green colour. It was from this plant that the isoflavone genistein was first isolated in 1899; hence the name of the chemical compound. The...
A. carnea and A. fortunei. However, A. americana had larger levels of genistein than the other two species. The fatty acid content of tubers is approximately...
and methimazole. In laboratory rats with insufficient iodine intake, genistein has demonstrated inhibition of TPO. Thyroid peroxidase is a frequent epitope...
Most studies of phytoestrogens in soy have identified the isoflavones genistein and daidzein as its principal phytoestrogenic substances. For several...
backbone (case of isoflavanes, such as equol). Daidzein Equol Flavonoid Genistein Glycitein Homoisoflavonoids, related molecules with a 16-carbon skeleton...
Other names Biochanin 4′-Methylgenistein olmelin Biochanine A Biochanin-A Genistein 4-methyl ether Identifiers CAS Number 491-80-5 Y 3D model (JSmol) Interactive...
and prunasin, the derivatives of which produce prussic acid as well as Genistein can be extracted from P. maximowiczii. Prunus maximowiczii was originally...
during August and September. It is rich in bioactive isoflavones such as genistein, daidzein, formononetin and pseudobaptigenin. This juicy tuber is a highly...
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