Thyroid peroxidase, also called thyroperoxidase (TPO), thyroid specific peroxidase or iodide peroxidase, is an enzyme expressed mainly in the thyroid where it is secreted into colloid. Thyroid peroxidase oxidizes iodide ions to form iodine atoms for addition onto tyrosine residues on thyroglobulin for the production of thyroxine (T4) or triiodothyronine (T3), the thyroid hormones.[1] In humans, thyroperoxidase is encoded by the TPO gene.[2]
^Ruf J, Carayon P (Jan 2006). "Structural and functional aspects of thyroid peroxidase". Archives of Biochemistry and Biophysics. 445 (2): 269–77. doi:10.1016/j.abb.2005.06.023. PMID 16098474.
^Kimura S, Kotani T, McBride OW, Umeki K, Hirai K, Nakayama T, Ohtaki S (Aug 1987). "Human thyroid peroxidase: complete cDNA and protein sequence, chromosome mapping, and identification of two alternately spliced mRNAs". Proceedings of the National Academy of Sciences of the United States of America. 84 (16): 5555–9. Bibcode:1987PNAS...84.5555K. doi:10.1073/pnas.84.16.5555. PMC 298901. PMID 3475693.
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Thyroidperoxidase, also called thyroperoxidase (TPO), thyroid specific peroxidase or iodide peroxidase, is an enzyme expressed mainly in the thyroid...
one or more components on the thyroid. The most clinically relevant anti-thyroid autoantibodies are anti-thyroidperoxidase antibodies (anti-TPO antibodies...
tyrosine units in thyroglobulin by the enzyme thyroidperoxidase. This forms the precursors of thyroid hormones monoiodotyrosine (MIT), and diiodotyrosine...
infiltration of the thyroid gland with T lymphocytes and autoantibodies against specific thyroid antigens such as thyroidperoxidase, thyroglobulin and...
Thyroid disease is a medical condition that affects the function of the thyroid gland. The thyroid gland is located at the front of the neck and produces...
into following six classes. These drugs probably inhibit the enzyme thyroidperoxidase (a.k.a. thyroperoxidase), decreasing iodide oxidation, iodination...
prevents thyroidperoxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones...
Desiccated thyroid, also known as thyroid extract, is thyroid gland that has been dried and powdered for medical use. It is used to treat hypothyroidism...
[citation needed] This is due to inability to produce thyroid hormones due to congenital absence of peroxidase or dehalogenase enzymes[citation needed] One particular...
Thyroid hormones are any hormones produced and released by the thyroid gland, namely triiodothyronine (T3) and thyroxine (T4). They are tyrosine-based...
excessive production of thyroid hormones by the thyroid gland. Thyrotoxicosis is the condition that occurs due to excessive thyroid hormone of any cause...
to form in eosinophil and thyroidperoxidases. Heme l is one important characteristic of animal peroxidases; plant peroxidases incorporate heme B. Lactoperoxidase...
family of medications. It works by decreasing the amount of thyroid hormone produced by the thyroid gland and blocking the conversion of thyroxine (T4) to...
offspring compared to children of mothers with normal thyroid function. Even maternal thyroidperoxidase antibodies were shown to be associated with impaired...
hormone, a step done after the oxidation of iodide by the enzyme thyroidperoxidase (TPO). Since iodine is an inorganic compound, and is being attached...
similarities with its orthologous peroxidases, myeloperoxidase (MPO), lactoperoxidase (LPO), and thyroidperoxidase (TPO). The protein is concentrated...
heaviest essential mineral nutrient, iodine is required for the synthesis of thyroid hormones. Iodine deficiency affects about two billion people and is the...
PMID 17204267. White, W. E.; Pruitt, K. M.; Mansson-Rahemtulla, B. (1983). "Peroxidase-Thiocyanate-Peroxide Antibacterial System Does not Damage DNA". Antimicrobial...
is 125 mg/kg for rats (oral). A goitrogenic effect (enlargement of the thyroid gland) has been reported for chronic exposure, reflecting the ability of...
occurs when the thyroid gland begins to produce an excess of thyroid hormone. The drug may also be taken before thyroid surgery to lower thyroid hormone levels...
improved oral bioavailability. Thioamides inhibit the enzyme thyroidperoxidase in the thyroid, reducing the synthesis of triiodothyronine (T3) and thyroxine...
infant formula, and is a component of the antioxidant enzymes glutathione peroxidase and thioredoxin reductase (which indirectly reduce certain oxidized molecules...
glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Tg is secreted and accumulated at hundreds of...
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