Liothyronine information

Liothyronine
Clinical data
Trade names	Cytomel, Tertroxin, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682462
License data	US DailyMed: Liothyronine;
Routes of; administration	By mouth, intravenous
ATC code	H03AA02 (WHO) ;
Legal status
Legal status	UK: POM (Prescription only);
Pharmacokinetic data
Protein binding	99.7%
Elimination half-life	2.5 days
Identifiers
	IUPAC name sodium (S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate;
CAS Number	6893-02-3 ;
PubChem CID	16218759;
IUPHAR/BPS	2634;
DrugBank	DB00279 ;
ChemSpider	17346129 ;
UNII	06LU7C9H1V;
ChEBI	CHEBI:6484 ;
ChEMBL	ChEMBL1201119 ;
PDB ligand	T3 (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID8047505 ;
ECHA InfoCard	100.000.203
Chemical and physical data
Formula	C15H11I3NNaO4
Molar mass	672.959 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [Na+].[O-]C(=O)[C@@H](N)Cc2cc(I)c(Oc1cc(I)c(O)cc1)c(I)c2.O;
	InChI InChI=1S/C15H12I3NO4.Na.H2O/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;;/h1-4,6,12,20H,5,19H2,(H,21,22);;1H2/q;+1;/p-1/t12-;;/m0../s1 ; Key:IRGJMZGKFAPCCR-LTCKWSDVSA-M ;
	(what is this?) (verify)

Liothyronine is a manufactured form of the thyroid hormone triiodothyronine (T₃).^[1] It is most commonly used to treat hypothyroidism and myxedema coma.^[1] It can be taken by mouth or by injection into a vein.^[1]

Side effects may occur from excessive doses.^[1] This may include weight loss, fever, headache, anxiety, trouble sleeping, arrythmias, and heart failure.^[1] Use in pregnancy and breastfeeding is generally safe.^[2]^[1] Regular blood tests are recommended to verify the appropriateness of the dose being taken.^[1]

Liothyronine was approved for medical use in 1956.^[1] It is available as a generic medication.^[2] In 2021, it was the 199th most commonly prescribed medication in the United States, with more than 2 million prescriptions.^[3]^[4]

^ ^a ^b ^c ^d ^e ^f ^g ^h "Liothyronine Sodium Monograph for Professionals". Drugs.com. Retrieved 27 February 2019.
^ ^a ^b British National Formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 757. ISBN 9780857113382.
^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^ "Liothyronine - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.

[AHFS2019-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h "Liothyronine Sodium Monograph for Professionals". Drugs.com. Retrieved 27 February 2019.

[BNF76-2] British National Formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 757. ISBN 9780857113382.

[3] "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.

[4] "Liothyronine - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.

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