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Ephrin B1 information


EFNB1
Identifiers
AliasesEFNB1, CFND, CFNS, EFB1, EFL3, EPLG2, Elk-L, LERK2, ephrin B1
External IDsOMIM: 300035; MGI: 102708; HomoloGene: 3263; GeneCards: EFNB1; OMA:EFNB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004429

NM_010110

RefSeq (protein)

NP_004420

NP_034240

Location (UCSC)Chr X: 68.83 – 68.84 MbChr X: 98.18 – 98.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ephrin B1 is a protein that in humans is encoded by the EFNB1 gene.[5][6] It is a member of the ephrin family. The encoded protein is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000090776 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031217 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fletcher FA, Huebner K, Shaffer LG, Fairweather ND, Monaco AP, Muller U, Druck T, Simoneaux DK, Chelly J, Belmont JW, et al. (Jul 1995). "Assignment of the gene (EPLG2) encoding a high-affinity binding protein for the receptor tyrosine kinase Elk to a 200-kilobasepair region in human chromosome Xq12". Genomics. 25 (1): 334–5. doi:10.1016/0888-7543(95)80156-G. PMID 7774950.
  6. ^ Shotelersuk V, Siriwan P, Ausavarat S (Mar 2006). "A novel mutation in EFNB1, probably with a dominant negative effect, underlying craniofrontonasal syndrome". Cleft Palate Craniofac J. 43 (2): 152–4. doi:10.1597/05-014.1. PMID 16526919. S2CID 10737616.
  7. ^ "Entrez Gene: EFNB1 ephrin-B1".

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Ephrin B1

Last Update:

Ephrin B1 is a protein that in humans is encoded by the EFNB1 gene. It is a member of the ephrin family. The encoded protein is a type I membrane protein...

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Ephrin

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Ephrins (also known as ephrin ligands or Eph family receptor interacting proteins) are a family of proteins that serve as the ligands of the Eph receptor...

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Craniofrontonasal dysplasia

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a very rare X-linked malformation syndrome caused by mutations in the ephrin-B1 gene (EFNB1). Phenotypic expression varies greatly amongst affected individuals...

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Growth factor

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(GM-CSF) Epidermal growth factor (EGF) Ephrins Ephrin A1 Ephrin A2 Ephrin A3 Ephrin A4 Ephrin A5 Ephrin B1 Ephrin B2 Ephrin B3 Erythropoietin (EPO) Fibroblast...

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Ephrin receptor

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EphA10) and five EphBs (EphB1-4 and EphB6). In general, Ephs of a particular subclass bind preferentially to all ephrins of the corresponding subclass...

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Cedar virus

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studies. Unlike Hendra and Nipah, which attach to Ephrin B2 or B3, Cedar virus can also attach to Ephrin B1. This may be responsible for lack of observed...

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Henipavirus

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case of MojV-G) is to attach the virus to the surface of a host cell via Ephrin B1, B2, or B3, a family of highly conserved mammalian proteins. The structure...

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EPH receptor B1

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this gene is a receptor for ephrin-B family members. EPH receptor B1 has been shown to interact with: ACP1 GRB7 and NCK1 Ephrin-B2 GRCh38: Ensembl release...

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Ephrin B2

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Ephrin-B2 is a protein that in humans is encoded by the EFNB2 gene. This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related...

Word Count : 1320

Phosphoproteomics

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unstimulated and EphrinB1-stimulated cells. Of these 127 proteins, 40 showed increased phosphorylation with stimulation by EphrinB1. The researchers were...

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Ephrin A1

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Ephrin A1 is a protein that in humans is encoded by the EFNA1 gene. This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related...

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Ephrin A5

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Ephrin A5 is a protein that in humans is encoded by the EFNA5 gene. Ephrin A5 is a glycosylphosphatidylinositol (GPI)-anchored protein of the ephrin-A...

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Ephrin A2

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Ephrin-A2 is a protein that in humans is encoded by the EFNA2 gene. This gene encodes a member of the ephrin family. The protein is composed of a signal...

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Ephrin B3

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Ephrin-B3 is a protein that in humans is encoded by the EFNB3 gene. EFNB3, a member of the ephrin gene family, is important in brain development as well...

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EPH receptor B4

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Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental...

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Ephrin A4

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Ephrin A4 is a protein that in humans is encoded by the EFNA4 gene. This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related...

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Ralf Adams

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For example, they were the first to show that the Eph receptor ligand ephrin-B1 controls skeletal morphogenesis and that defects in the human gene (EFNB1)...

Word Count : 531

Ephrin A3

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Ephrin A3 is a protein that in humans is encoded by the EFNA3 gene. This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related...

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Neuronal lineage marker

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1/CRIM1; c-Ret phosphor Serine 696; Doublecortin/DCX; Ephrin A2; Ephrin A4; Ephrin A5; Ephrin B1; Ephrin B2; GAP-43; HuC; HuD; Internexin alpha; Laminin-1;...

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Tropic cues involved in growth cone guidance

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the interaction of numerous trophic and tropic factors; netrins, slits, ephrins and semaphorins are four well-studied tropic cues (Fig.1). The growth cone...

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Neurotrophic factors

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of receptor tyrosine kinases; the family of ephrins include ephrin A1, A2, A3, A4, A5, B1, B2, and B3. The EGF and TGF families of neurotrophic factors...

Word Count : 1784

EPH receptor A4

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EPH receptor A4 (ephrin type-A receptor 4) is a protein that in humans is encoded by the EPHA4 gene. This gene belongs to the ephrin receptor subfamily...

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Cardiac neural crest

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EphrinA and Ephrin B variations. This corresponds with receptor expression at the pharyngeal arches. Pharyngeal arch 3 expresses EphrinA and EphrinB1...

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EPHA10

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encoded by the EPHA10 gene. Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators...

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EPH receptor A2

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EPH receptor A2 (ephrin type-A receptor 2) is a protein that in humans is encoded by the EPHA2 gene. This gene belongs to the ephrin receptor subfamily...

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Optic chiasm

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nerves is guided primarily by cues such as netrin, slit, semaphorin and ephrin; and by morphogens such as sonic hedgehog (Shh) and Wnt. This navigation...

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EPH receptor A3

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EPH receptor A3 (ephrin type-A receptor 3) is a protein that in humans is encoded by the EPHA3 gene. This gene belongs to the ephrin receptor subfamily...

Word Count : 1046

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