Structure of the kinase domain of human eph type-A receptor 5 (EphA5)
Identifiers
Symbol
Ephrin_lbd
Pfam
PF01404
InterPro
IPR016257
SCOP2
1nuk / SCOPe / SUPFAM
CDD
cd10319
Membranome
1202
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Eph receptors (Ephs, after erythropoietin-producing human hepatocellular receptors) are a group of receptors that are activated in response to binding with Eph receptor-interacting proteins (Ephrins). Ephs form the largest known subfamily of receptor tyrosine kinases (RTKs). Both Eph receptors and their corresponding ephrin ligands are membrane-bound proteins that require direct cell-cell interactions for Eph receptor activation. Eph/ephrin signaling has been implicated in the regulation of a host of processes critical to embryonic development including axon guidance,[1] formation of tissue boundaries,[2] cell migration, and segmentation.[3] Additionally, Eph/ephrin signaling has been identified to play a critical role in the maintenance of several processes during adulthood including long-term potentiation,[4] angiogenesis,[5] and stem cell differentiation and cancer.[6]
^Egea J, Klein R (May 2007). "Bidirectional Eph-ephrin signaling during axon guidance". Trends Cell Biol. 17 (5): 230–8. doi:10.1016/j.tcb.2007.03.004. PMID 17420126.
^Rohani N, Canty L, Luu O, Fagotto F, Winklbauer R (March 2011). Hamada H (ed.). "EphrinB/EphB signaling controls embryonic germ layer separation by contact-induced cell detachment". PLOS Biol. 9 (3): e1000597. doi:10.1371/journal.pbio.1000597. PMC 3046958. PMID 21390298.
^Davy A, Soriano P (January 2005). "Ephrin signaling in vivo: look both ways". Dev. Dyn. 232 (1): 1–10. doi:10.1002/dvdy.20200. PMID 15580616. S2CID 37808863.
^Kullander K, Klein R (July 2002). "Mechanisms and functions of Eph and ephrin signalling". Nat. Rev. Mol. Cell Biol. 3 (7): 475–86. doi:10.1038/nrm856. PMID 12094214. S2CID 1735440.
with Eph receptor-interacting proteins (Ephrins). Ephs form the largest known subfamily of receptor tyrosine kinases (RTKs). Both Eph receptors and their...
Ephrins (also known as ephrin ligands or Eph family receptor interacting proteins) are a family of proteins that serve as the ligands of the Eph receptor...
EPH receptor A2 (ephrin type-A receptor 2) is a protein that in humans is encoded by the EPHA2 gene. This gene belongs to the ephrinreceptor subfamily...
EPH receptor A4 (ephrin type-A receptor 4) is a protein that in humans is encoded by the EPHA4 gene. This gene belongs to the ephrinreceptor subfamily...
EPH receptor A1 (ephrin type-A receptor 1) is a protein that in humans is encoded by the EPHA1 gene. This gene belongs to the ephrinreceptor subfamily...
Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. Ephrinreceptors and their ligands, the ephrins, mediate numerous developmental...
EPH receptor A3 (ephrin type-A receptor 3) is a protein that in humans is encoded by the EPHA3 gene. This gene belongs to the ephrinreceptor subfamily...
Ephrin type-B receptor 2 is a protein that in humans is encoded by the EPHB2 gene. Ephrinreceptors and their ligands, the ephrins, mediate numerous developmental...
transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. EFNB2 gene has been observed progressively downregulated...
Ephrin B1 is a protein that in humans is encoded by the EFNB1 gene. It is a member of the ephrin family. The encoded protein is a type I membrane protein...
Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene. This gene encodes a member of the ephrinreceptor subfamily of the protein-tyrosine...
EPH receptor A5 (ephrin type-A receptor 5) is a protein that in humans is encoded by the EPHA5 gene. This gene belongs to the ephrinreceptor subfamily...
Ephrin type-B receptor 1 is a protein that in humans is encoded by the EPHB1 gene. Ephrinreceptors and their ligands, the ephrins, mediate numerous developmental...
subclass of ephrin ligands that binds to the EphA subclass of Eph receptors. Ephrin A5 has also been shown to bind to the EphB2 receptor. "Reverse" signaling...
ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997) based on their structures and sequence relationships. Ephrins are...
Ephrin A4 is a protein that in humans is encoded by the EFNA4 gene. This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related...
Ephrin type-B receptor 3 is a protein that in humans is encoded by the EPHB3 gene. Ephrinreceptors and their ligands, the ephrins, mediate numerous developmental...
Ephrin A3 is a protein that in humans is encoded by the EFNA3 gene. This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related...
Library of Medicine. "Entrez Gene: EFNA2 ephrin-A2". Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev....
proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different...
Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming...
tyrosines then initiates intracellular signal transduction processes. Ephrinreceptors are the largest subfamily of RTKs. The DDRs are unique RTKs in that...
Ephrin type-A receptor 7 is a protein that in humans is encoded by the EPHA7 gene. This gene belongs to the ephrinreceptor subfamily of the protein-tyrosine...
EPH or Eph may refer to: Ephedrine Ephrinreceptor Extractable petroleum hydrocarbons Environmental Public Health East Pakenham railway station, Melbourne...
Ephrin type-B receptor 6 is a protein that in humans is encoded by the EPHB6 gene. Ephrinreceptors and their ligands, the ephrins, mediate numerous developmental...
EPH receptor A10 is a protein in humans that is encoded by the EPHA10 gene. Ephrinreceptors, the largest subfamily of receptor tyrosine kinases (RTKs)...
Glutamate [NMDA] receptor subunit epsilon-2, also known as N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B), is a protein that in humans is...
to neuronal migration. Ephrin'sreceptor is called Eph and is a receptor tyrosine kinase. Upon activation of the Eph receptor, synaptojanin 1 becomes...
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