This article is about enzyme regulation at the gene expression level. For the inhibition of enzymes at the enzyme level, see Enzyme inhibitor.
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Enzyme induction is a process in which a molecule (e.g. a drug) induces (i.e. initiates or enhances) the expression of an enzyme.
Enzyme inhibition can refer to
the inhibition of the expression of the enzyme by another molecule
interference at the enzyme-level, basically with how the enzyme works. This can be competitive inhibition, uncompetitive inhibition, non-competitive inhibition or partially competitive inhibition.
If the molecule induces enzymes that are responsible for its own metabolism, this is called auto-induction (or auto-inhibition if there is inhibition). These processes are particular forms of gene expression regulation.
These terms are of particular interest to pharmacology, and more specifically to drug metabolism and drug interactions. They also apply to molecular biology.
and 26 Related for: Enzyme induction and inhibition information
Enzymeinduction is a process in which a molecule (e.g. a drug) induces (i.e. initiates or enhances) the expression of an enzyme. Enzymeinhibition can...
medicine Induced stem cells, derived from other cell types EnzymeinductionandinhibitionInduction period, slow stage of a reaction Inductive cleavage, in...
spontaneously leave the enzyme, allowing the enzyme to resume its function. Reversible inhibitors produce different types of inhibition depending on whether...
comes from enzymes in the liver called cytochrome P450 oxidases, which are important in drug metabolism. Induction or inhibition of these enzymes can cause...
An enzyme inducer is a type of drug that increases the metabolic activity of an enzyme either by binding to the enzymeand activating it, or by increasing...
of the enzymes can either be stimulated (enzymeinduction) or inhibited (enzymeinhibition). If a drug is metabolized by a CYP450 enzymeand drug B blocks...
oxytosis/ferroptosis induction; therefore, these compounds can be inhibited by iron chelators. Erastin acts through inhibition of the cystine/glutamate...
(abbreviated CYP3A4) (EC 1.14.13.97) is an important enzyme in the body, mainly found in the liver and in the intestine, which in humans is encoded by CYP3A4...
systematic name peptidoglycan N-acetylmuramoylhydrolase) is an antimicrobial enzyme produced by animals that forms part of the innate immune system. It is a...
that inhibition of the enzyme might have extensive practical application for treatment of hormone-dependent breast cancer, alterations of ovarian and endometrial...
transporter blockade, induction of transmitter release, andinhibition of transmitter breakdown. Cocaine is a monoamine transporter blocker and, thus, an indirect...
women. Ovulation inhibition is an antigonadotropic effect and is mediated by inhibition of the secretion of the gonadotropins, LH and FSH, from the pituitary...
point towards inhibition of demethylase synthesis and/or induction of demetylase degradation. Unpublished observations of Venkatesan, Argus and Arcos suggest...
physiological role of dephosphorylating compounds. The enzyme is found across a multitude of organisms, prokaryotes and eukaryotes alike, with the same general function...
mimic the substrate phosphoenolpyruvate (PEP). The irreversible inhibition of this enzyme stops the cytoplasmic biosynthesis of peptidoglycan precursor...
14.14.14), also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens. It is CYP19A1...
Jacob and Jacques Monod to determine how a biological cell knows which enzyme to synthesize. Their work on the lac operon won them the Nobel Prize in...
inhibits acetylcholinesterase, an enzyme which hydrolyzes acetylcholine. As a result of acetylcholinesterase inhibition, galantamine increases the availability...
entomotoxicity, inhibition of fungi, neurotoxicity in mammals, promotion of endocytosis and inflammatory eicosanoid production in mammals, andinduction of chemotaxis...
true, as in enzymeinhibition. However, in cases where an enzyme is responsible for metabolizing a pro-drug into a drug, enzymeinduction can accelerate...
Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of deoxynucleotides and increased levels of dUMP arise. Both cause DNA damage...
leaves the question concerning what causes inhibition of glucose oxidation. The discovery that HClO blocks induction of β-galactosidase by added lactose led...
prostacyclin and prostaglandin D, E and F. Alternatively, the lipoxygenase enzyme pathway is active in leukocytes and in macrophages and synthesizes leukotrienes...
chemoprevention in women at high risk for breast cancer. Aromatase is the enzyme that catalyzes a key aromatization step in the synthesis of estrogen. It...
phosphorylation of enzymesand regulatory proteins by Protein Kinase A (a cyclic AMP regulated kinase) resulting in inhibition of glycolysis and stimulation...
follicles to grow continuously and maintain the anagen phase. Due to anti-fibrotic activity of minoxidil inhibition of enzyme lysyl hydroxylase present in...
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