Global InformationCynaropicrin information
Cynaropicrin is a sesquiterpene lactone of the guaianolide type found mainly in leaves of artichoke plants. It is one of the compounds that gives the artichoke its characteristic bitterness. It is found in artichoke leaves with an abundance of approximately 87 g/kg, but can hardly be found in other parts of the plant.[1] Cynaropicrin makes up about 0.7% of leaf extracts of the artichoke. It exhibits a large diversity of bioactivities and shows properties such as anti-inflammatory, antifeedant and activation of bitter sensory receptors,[2] but has not yet been used in medicine. Despite its pharmacologically beneficial properties, it can be toxic in higher doses. The compound has attracted attention in recent years as a potential anticancer drug.[3]
- ^ Ramos, Patrícia A. B.; Guerra, Ângela R.; Guerreiro, Olinda; Freire, Carmen S. R.; Silva, Artur M. S.; Duarte, Maria F.; Silvestre, Armando J. D. (2013-08-21). "Lipophilic Extracts of Cynara cardunculus L. var. altilis (DC): A Source of Valuable Bioactive Terpenic Compounds". Journal of Agricultural and Food Chemistry. 61 (35): 8420–8429. doi:10.1021/jf402253a. ISSN 0021-8561. PMID 23915287.
- ^ Elsebai, Mahmoud Fahmi; Mocan, Andrei; Atanasov, Atanas G. (2016). "Cynaropicrin: a comprehensive research review and therapeutic potential as an anti- hepatitis C virus agent". Frontiers in Pharmacology. 7: 472. doi:10.3389/fphar.2016.00472. ISSN 1663-9812. PMC 5143615. PMID 28008316.
- ^ Liu, Tianyu; Zhang, Junmin; Han, Xiao; Xu, Jianqiang; Wu, Yueting; Fang, Jianguo (2019-05-01). "Promotion of HeLa cells apoptosis by cynaropicrin involving inhibition of thioredoxin reductase and induction of oxidative stress". Free Radical Biology and Medicine. 135: 216–226. doi:10.1016/j.freeradbiomed.2019.03.014. ISSN 0891-5849. PMID 30880248. S2CID 81981653.